Patents by Inventor Frank J. Konings

Frank J. Konings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5681755
    Abstract: An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 28, 1997
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marcus J. M. Noppe, Frank J. Konings
  • Patent number: 5674755
    Abstract: An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marcus J. M. Noppe, Frank J. Konings
  • Patent number: 5498551
    Abstract: New method for the detection of specific binding agents and their corresponding bindable substances by employing a label which is a latex particle which can be visually detected.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: March 12, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nikolaas C. J. de Jaeger, Marcel J. Monbaliu, Marcus J. M. Noppe, Frank J. Konings
  • Patent number: 5491098
    Abstract: An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: February 13, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marcus J. M. Noppe, Frank J. Konings
  • Patent number: 5376632
    Abstract: The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or spray-dried erythropoietin compositions comprising a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative, to processes for preparing such aqueous, lyophilized or spray-dried compositions and to a method for simultaneously stabilizing erythropoietin in an aqueous solution and preventing it from being adsorbed to surfaces.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: December 27, 1994
    Inventors: Frank J. Konings, Marcus J. M. Noppe, Jean L. Mesens
  • Patent number: 4837168
    Abstract: New method for the detection of specific binding agents and their corresponding bindable substances by employing a label which is a latex particle which can be visually detected.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: June 6, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nikolaas C. J. de Jaeger, Marcel J. Monbaliu, Marcus J. M. Noppe, Frank J. Konings