Abstract: Provided herein are compounds that act as molecular glues, inducing degradation of CK1? or CK1?/GSPT1, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with a proliferative disease.

Abstract: A custom decoration for bags, cases, portfolios and other business accessories (the “item”) that can be printed at an appropriate location directly on the otherwise-finished item is provided. The decoration comprises a single or multi-colored ink image transferred from a lithographic plate using a transfer pad. The underlying tag or “substrate” for the decoration is a smooth-surfaced soft polyvinylchloride or rubberized material with appropriate ink-receptive or attractive characteristic—such as a matte or semi-gloss surface finish. The item is placed on a supporting surface in a pad printing device so that the substrate is restrained within a registration jig; an inked image on a plate is contacted with a printing pad and the pad is moved to contact the substrate, thereby applying the custom decoration thereto. In one embodiment, the substrate is secured by cords to a side of the item.

Abstract: A base or pallet that is variably adjustable along its width to specifically accommodate a wide range of differently sized pieces of clothing is provided. A main pallet base is flanked by a pair of extendable and retractable (movable) wings, along the underside thereof, that are constructed from a durable material and that extend simultaneously in opposing directions. In an illustrative embodiment, a movement-balancing mechanism, such as a rack-and-pinion assembly or pantograph, is used to extend and retract the wings at a similar rate. In this manner, pulling or pushing on one wing causes the other to move simultaneously. The wings are locked in place using a locking mechanism beneath the outer-facing side of the main base. The locking mechanism can be a block that applies friction to one of the rack sets of the rack-and-pinion assembly or other movement-balancing mechanism.