Abstract: An electric vehicle is provided. The vehicle includes a frame. A battery and a motor may be secured to the frame, such that the battery powers the motor which drives the vehicle. The vehicle may further include at least one axle including a plurality of wheels. A manual steering mechanism including a steering column is operable to pivot the wheels when the steering column is rotated. An overhead frame protrudes vertically from the main frame. A steering drive shaft is supported by the overhead frame and is operable to pivot the wheels when rotated. A head unit is secured to the steering drive shaft and includes a positive electrode and a negative electrode electrically wired to the battery. The head unit is operable to engage an overhead track. The overhead track transfers electrical power to the positive electrode and negative electrode, thereby recharging the battery and driving the motor while steering the electric vehicle.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.

Abstract: A modular steel-framed construction mold apparatus comprised of a plurality of contiguous foundation, cavity wall and roof deck void spaces defined and formed by assemblies of interlocking encasement panels and connectors integrally attached to a structural steel grillage for accepting, containing, and shaping wet concrete fill, a method for forming, casting, and encasing monolithic composite concrete and steel buildings and structures in situ using said mold apparatus, and a permanently encased monolithic composite concrete and steel structure constructed by employing the foregoing modular mold apparatus and method of concrete construction. The structural steel grillage supports the encasement assemblies before and during the casting process, becoming fully embedded within the cast concrete, and provides tensile strength complementing the compressive strength of concrete fill.

Abstract: An electric vehicle is provided. The vehicle includes a frame. A battery and a motor may be secured to the frame, such that the battery powers the motor which drives the vehicle. The vehicle may further include at least one axle including a plurality of wheels. A manual steering mechanism including a steering column is operable to pivot the wheels when the steering column is rotated. An overhead frame protrudes vertically from the main frame. A steering drive shaft is supported by the overhead frame and is operable to pivot the wheels when rotated. A head unit is secured to the steering drive shaft and includes a positive electrode and a negative electrode electrically wired to the battery. The head unit is operable to engage an overhead track. The overhead track transfers electrical power to the positive electrode and negative electrode, thereby recharging the battery and driving the motor while steering the electric vehicle.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: A combustor dome and heat-shield assembly comprises a heat-shield having a first opening therethrough. A swirler extends through the first opening and captures the heat-shield. A dome having a second opening therethrough and has an upstream side and a downstream side. The swirler extends through the second opening from the downstream side to the upstream side to capture the heat-shield on the downstream side, and a retaining clip engages the swirler to secure the swirler and the heat-shield on the dome.

Abstract: Provided herein are formulations and methods for treating pain in human beings. Also provided are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single pharmaceutical dosing unit.

Abstract: A secure card package including features such that an activable card disposed in the secure card package is activable only upon separation of a first portion and a second portion. The first portion and the second portion are separably interconnected along a separation line such that upon separation of the first portion and the second portion a reference edge is defined. A machine-readable activation data field is disposed on one of the first portion or second portion with respect to the reference edge such that the machine-readable activation data field is only readable upon separation of the first portion and the second portion to define the reference edge.

Abstract: Integrated circuits and methods for fabricating integrated circuits are provided. In an embodiment, an integrated circuit includes a standard cell having a first boundary, a second boundary opposite the first boundary, a third boundary interconnecting the first and second boundaries, and a fourth boundary opposite the third boundary and interconnecting the first and second boundaries. The standard cell further includes parallel active areas extending from the first boundary to the second boundary. Also, the standard cell has parallel gate strips extending from the third boundary to the fourth boundary and over the active areas. A cut mask overlies the gate strips. An interconnect is positioned overlying the cut mask and forms an electrical connection with a selected gate strip.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.

Abstract: A combustor dome and heat-shield assembly comprises a heat-shield having a first opening therethrough. A swirler extends through the first opening and captures the heat-shield. A dome having a second opening therethrough and has an upstream side and a downstream side. The swirler extends through the second opening from the downstream side to the upstream side to capture the heat-shield on the downstream side, and a retaining clip engages the swirler to secure the swirler and the heat-shield on the dome.

Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

Abstract: Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.

Abstract: Systems and methods for creating and maintaining multi-manager exchange traded funds. An embodiment of a method includes receiving a plurality of model portfolios, each created by a different portfolio manager and identifying a plurality of assets traded on a stock exchange. A portfolio composition file is created based at least in part on at least a portion of the model portfolios. The portfolio composition file identifies a set of constituent assets traded on the stock exchange. One or more authorized participants are authorized to trade the set of constituent assets for a creation unit of an exchange traded fund. The creation unit includes at least one share that is tradable on the stock exchange by both the authorized participant(s) and the investors.

Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.

Abstract: Novel synthetic glycosphingolipids and pharmaceutical compositions containing such synthetic glycosphingolipids are described. Methods of making the novel synthetic glycosphingolipid compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.

Abstract: A modular steel-framed construction mold apparatus comprised of a plurality of contiguous foundation, cavity wall and roof deck void spaces defined and formed by assemblies of interlocking encasement panels and connectors integrally attached to a structural steel grillage for accepting, containing, and shaping wet concrete fill, a method for forming, casting, and encasing monolithic composite concrete and steel buildings and structures in situ using said mold apparatus, and a permanently encased monolithic composite concrete and steel structure constructed by employing the foregoing modular mold apparatus and method of concrete construction. The structural steel grillage supports the encasement assemblies before and during the casting process, becoming fully embedded within the cast concrete, and provides tensile strength complementing the compressive strength of concrete fill.

Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.