Patents by Inventor Frank Kowalewsky

Frank Kowalewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-variant Fc-region antibodies and method of use
    Patent number: 11970550
    Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations 1253A/H310A/H435A in the Fc-region, and methods of using the same.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: April 30, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Frank Kowalewsky, Mirko Ritter, Kay-Gunnar Stubenrauch, Uwe Wessels
  • ANTI-VARIANT FC-REGION ANTIBODIES AND METHOD OF USE
    Publication number: 20210163626
    Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations 1253A/H310A/H435A in the Fc-region, and methods of using the same.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 3, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Frank Kowalewsky, Mirko Ritter, Kay-Gunnar Stubenrauch, Uwe Wessels
  • Anti-variant Fc-region antibodies and method of use
    Patent number: 10899845
    Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations I253A/H310A/H435A in the Fc-region, and methods of using the same.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: January 26, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Frank Kowalewsky, Mirko Ritter, Kay-Gunnar Stubenrauch, Uwe Wessels
  • Antibody specifically binding to insulin-like growth factor-1
    Patent number: 10301383
    Abstract: Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: May 28, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Herbert Andres, Hartmut Duefel, Michael Gerg, Frank Kowalewsky, Christian Scholz, Michael Schraemi
  • ANTI-VARIANT FC-REGION ANTIBODIES AND METHOD OF USE
    Publication number: 20180346602
    Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations I253A/H310A/H435A in the Fc-region, and methods of using the same.
    Type: Application
    Filed: April 25, 2018
    Publication date: December 6, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Frank Kowalewsky, Mirko Ritter, Kay-Gunnar Stubenrauch, Uwe Wessels
  • Non-cross-reactive anti IgG antibodies
    Patent number: 9957331
    Abstract: Herein are reported the cell lines DSM ACC3006, DSM ACC3007, and DSM ACC3008, as well as the antibodies obtained from the cell lines and the use of an antibody obtained from the cell lines in an immunoassay. Also are reported antibodies binding to human or chimpanzee IgG and not binding to canine and marmoset IgG and antibodies specifically binding to an IgG 1 that comprises a kappa light chain constant domain.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: May 1, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Essig, Stefan Klostermann, Frank Kowalewsky, Kay-Gunnar Stubenrauch, Rudolf Vogel, Uwe Wessels
  • Anti-human IgG1 antibody
    Patent number: 9766251
    Abstract: Herein are reported a monoclonal antibody specifically binding to a human IgG1 antibody and not specifically binding to the immunoglobulin of an experimental animal and the use of the antibody in immunoassays.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: September 19, 2017
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Ulrich Essig, Stefan Klostermann, Frank Kowalewsky, Kay-Gunnar Stubenrauch, Rudolf Vogel, Uwe Wessels
  • ANTIBODY SPECIFICALLY BINDING TO INSULIN-LIKE GROWTH FACTOR-1
    Publication number: 20160137728
    Abstract: Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
    Type: Application
    Filed: January 22, 2016
    Publication date: May 19, 2016
    Inventors: Herbert Andres, Hartmut Duefel, Michael Gerg, Frank Kowalewsky, Christian Scholz, Michael Schraeml
  • Antibody specifically binding to insulin-like growth factor-1
    Patent number: 9273144
    Abstract: Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 1, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Herbert Andres, Hartmut Duefel, Michael Gerg, Frank Kowalewsky, Christian Scholz, Michael Schraeml
  • ANTI-HUMAN IgG1 ANTIBODY
    Publication number: 20150323543
    Abstract: Herein are reported a monoclonal antibody specifically binding to a human IgG1 antibody and not specifically binding to the immunoglobulin of an experimental animal and the use of the antibody in immunoassays.
    Type: Application
    Filed: February 20, 2015
    Publication date: November 12, 2015
    Inventors: ULRICH ESSIG, STEFAN KLOSTERMANN, FRANK KOWALEWSKY, KAY-GUNNAR STUBENRAUCH, RUDOLF VOGEL, UWE WESSELS
  • ANTIBODY SPECIFICALLY BINDING TO INSULIN-LIKE GROWTH FACTOR-1
    Publication number: 20140120561
    Abstract: Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 1, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Herbert Andres, Hartmut Duefel, Michael Gerg, Frank Kowalewsky, Christian Scholz, Michael Schraeml
  • NON-CROSS-REACTIVE ANTI IGG ANTIBODIES
    Publication number: 20120208216
    Abstract: Herein are reported the cell lines DSM ACC3006, DSM ACC3007, and DSM ACC3008, as well as the antibodies obtained from the cell lines and the use of an antibody obtained from the cell lines in an immunoassay. Also are reported antibodies binding to human or chimpanzee IgG and not binding to canine and marmoset IgG and antibodies specifically binding to an IgG1 that comprises a kappa light chain constant domain.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 16, 2012
    Inventors: Ulrich Essig, Stefan Klostermann, Frank Kowalewsky, Kay-Gunnar Stubenrauch, Rudolf Vogel, Uwe Wessels