Patents by Inventor Frank Otto
Frank Otto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160318976Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: December 27, 2013Publication date: November 3, 2016Applicant: POLYPHOR AGInventors: Frank Otto GOMBERT, Daniel OBRECHT, Odile SELLIER-KESSLER
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Patent number: 9284352Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Cys4-Xaa5-Xaa6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa12, Xaa13, Xaa14, Xaa15 and Xaa16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair.Type: GrantFiled: August 22, 2014Date of Patent: March 15, 2016Assignee: POLYPHOR AGInventors: Daniel Obrecht, Frank Otto Gombert, Alexander Lederer, Barbara Romagnoli, Christian Bisang
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Patent number: 9284401Abstract: The present invention provides a process for the preparation of polyols based on fatty acid esters and starter compounds having Zerewitinoff-active hydrogen atoms and the use thereof for the preparation of polyurethane materials.Type: GrantFiled: March 5, 2007Date of Patent: March 15, 2016Assignees: Bayer MaterialScience LLC, Bayer MaterialScience AGInventors: Klaus Lorenz, Reinhard Albers, Frank Otto, Ulrich Leyrer, Don S. Wardius, Keith J. Headley
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Publication number: 20150307825Abstract: The invention relates to a method and a device for steeping, germinating, kilning, fermenting grain, wherein the device comprises a container (3) having at least one plate (20) which can be mounted in the container and having at least one opening (21) for the supply and/or removal of fluid. In addition, the container (3) has at least one base surface (4) wherein, on the base surface (4), substantially vertically arranged side surfaces (5) and, on the base surface (4), substantially vertically arranged end surfaces (9) are present. In addition, a covering surface (6) that is in particular substantially horizontally arranged on at least one side surface (5) and/or end surface (9) is present, as a result of which a process chamber is formed. The internal measurement of a side length of the end surface (9) is 2 to 2.5 meters, in particular 2.345 meters.Type: ApplicationFiled: September 30, 2011Publication date: October 29, 2015Applicant: BUHLER AGInventors: Frank-Otto Görlitz, Kai Silbermann, Wolf-Eckart Bischoff
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Publication number: 20150307556Abstract: Novel template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are ?-amino acid residues connected from the carbonyl (C?O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these ?-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells.Type: ApplicationFiled: July 9, 2015Publication date: October 29, 2015Applicant: POLYPHOR AGInventors: Frank Otto GOBERT, Alexander LEDERER, Ralf LÖWE, Daniel OBRECHT, Barbara ROMAGNOLI, Johann ZIMMERMANN, Kalpana PATEL
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Publication number: 20150266924Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Ala6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Aaa14-DPro15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa7, Xaa8, Xaa13 and Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Applicant: POLYPHOR AGInventors: Daniel OBRECHT, Frank Otto GOMBERT, Johann ZIMMERMANN
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Patent number: 9109009Abstract: Novel template-fixed ?-hairpin peptidomimetics of the general formula (I), wherein the single elements T or P are ?-amino acid residues connected from the carbonyl (C?O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these ?-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilization of stem cells.Type: GrantFiled: February 4, 2011Date of Patent: August 18, 2015Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Alexander Lederer, Ralf Löwe, Daniel Obrecht, Barbara Romagnoli, Johann Zimmermann, Kalpana Patel
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Publication number: 20150218219Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8 Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.Type: ApplicationFiled: June 6, 2012Publication date: August 6, 2015Applicant: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Alexander Lederer, Johann Zimmermann, Christian Oefner
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Patent number: 9079939Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Ala6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-DPro15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa7, Xaa8, Xaa13 and Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: June 6, 2012Date of Patent: July 14, 2015Assignee: POLYPHOR AGInventors: Daniel Obrecht, Frank Otto Gombert, Johann Zimmermann
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Patent number: 8955317Abstract: In a method for operating a supercharged internal combustion engine of a motor vehicle, at the same time an internal exhaust gas recirculation and an external exhaust gas recirculation are carried out in an engine operating range with lean burn operation modes, wherein the exhaust gas recirculation rate of the internal and the external exhaust gas recirculation is increased with increasing load and/or speed of the internal combustion engine in the lean engine operating range and, at high engine speeds and loads, a homogenous mixture operation is carried out. The invention also reside in an internal combustion engine for performing the method.Type: GrantFiled: December 16, 2012Date of Patent: February 17, 2015Assignee: Daimler AGInventors: Markus Schilling, Frank Otto, Klaus Roessler
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Publication number: 20140364583Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(—Xaa1—Xaa2—Xaa3—Cys4—Xaa5—Xaa6—Xaa7—Xaa8—Arg9—Tyr10—Cys11—Xaa12—Xaa13—Xaa14—Xaa15—Xaa16—), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa12, Xaa13, Xaa14, Xaa15 and Xaa16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair.Type: ApplicationFiled: August 22, 2014Publication date: December 11, 2014Inventors: Daniel OBRECHT, Frank Otto GOMBERT, Alexander LEDERER, Barbara ROMAGNOLI, Christian BISANG
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Patent number: 8895499Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-), enantiomers and pharmaceutically acceptable salts thereof, with Xaa1-Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have anti-infective activity, e.g. to selectively inhibit the growth of or to kill microorganisms such as Bacillus subtilis and/or Shigella boydii. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: August 5, 2010Date of Patent: November 25, 2014Assignees: Polyphor AG, Universitat ZurichInventors: Daniel Obrecht, Frank Otto Gombert, John Anthony Robinson, Krystyna Patora-Komisarska
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Publication number: 20140323605Abstract: The invention relates to stable emulsions for the production of foams based on isocyanate, at least comprising three polyols A1a, A1b and A1c as well as at least one physical blowing agent T, wherein A1a is a polyether polyol obtained by addition of epoxides to starter compounds selected from carbohydrates and di- or higher-functional alcohols, A1b is a polyether polyol started on an aromatic amine, and A1c is a polyester polyol obtained by esterification of a polycarboxylic acid component and a polyalcohol component, wherein the total amount of aromatic dicarboxylic acid derivatives used in the esterification, calculated on the basis of the free aromatic dicarboxylic acids and based on the total mass of polyalcohol component and polycarboxylic acid component, is less than or equal to 48.5% by mass.Type: ApplicationFiled: August 22, 2012Publication date: October 30, 2014Applicant: Bayer Intellectual Property GmbHInventors: Reinhard Albers, Torsten Heinemann, Stephanie Vogel, Hartmut Nefzger, Frank Otto
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Publication number: 20140242313Abstract: A cavity between inner and outer walls of an open-box-shaped mould is filled with a polyurethane reaction mixture, containing an isocyanate and an emulsion of an isocyanate-reactive composition with three polyols and a blowing agent, which is cured to a polyurethane containing polymer. The inner and outer wall are a fixed distance from one another and each wall comprises a bottom and sides. The mixture is fed through an inlet in the bottom of the outer wall. Before filling the cavity, the mould is turned downwards so that the mixture foams upwards, filling the cavity. The three polyols are polyether polyol obtained by adding an epoxy to carbohydrates or difunctional or higher-functional alcohols; polyether polyol obtained by adding an epoxy to an aromatic amine; and polyester polyether polyol obtained by adding an epoxy to the esterification product of an aromatic dicarboxylic acid derivative and a difunctional or higher-functional alcohol.Type: ApplicationFiled: February 20, 2014Publication date: August 28, 2014Applicant: BAYER MATERIALSCIENCE AGInventors: Stephanie VOGEL, Reinhard ALBERS, Michael LOOF, Frank OTTO
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Patent number: 8796183Abstract: A method of screening for template-fixed ?-hairpin mimetics and libraries including a plurality of these mimetics is provided. The template-fixed ?-hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2??I wherein the two cysteine residues are bridged by a disulfide bond, thereby forming a cyclic peptide; R1 and R2 are di- or tripeptide moieties of certain types, as defined herein; and Z is a chain of n amino acid residues with n being an integer from 4 to 20 and with each of these n amino acid residues being, independently, derived from any naturally occurring L-?-amino acid.Type: GrantFiled: August 2, 2011Date of Patent: August 5, 2014Assignees: Polyphor Ltd., Universität ZürichInventors: Jan Wim Vrijbloed, Daniel Obrecht, Sergio Locurio, Frank Otto Gombert, Christian Ludin, Françoise Jung
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Publication number: 20140213679Abstract: The invention relates to stable emulsions for the production of foams based on isocyanates, comprising at least three polyols A1a, A1b and A1c and at least one physical blowing agent T, wherein A1a is a polyether polyol, obtained by the addition of epoxies to starter compounds selected from carbohydrates and difunctional or higher-functional alcohols, A1b is a polyether polyol started on an aromatic amine and A1c is a polyester polyether polyol, obtained by the addition of epoxies to the esterification product of an aromatic dicarboxylic acid derivative and a difunctional or higher-functional alcohol. The invention further relates to a method for producing foams by reactions of such emulsions with isocyanates and to the foams obtainable in this way and their use for insulating purposes.Type: ApplicationFiled: August 22, 2012Publication date: July 31, 2014Applicant: Bayer Intellectual Property GmbHInventors: Reinhard Albers, Torsten Heinemann, Stephanie Vogel, Thomas Heidelmann, Frank Otto
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Publication number: 20140213509Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Ala6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-DPro15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa7, Xaa8, Xaa13 and Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: June 6, 2012Publication date: July 31, 2014Applicant: POLYPHOR AGInventors: Daniel Obrecht, Frank Otto Gombert, Johann Zimmermann
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Patent number: 8754038Abstract: Novel template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are ?-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: November 18, 2010Date of Patent: June 17, 2014Assignee: Polyphor AGInventors: Françoise Jung, Frank Otto Gombert, Daniel Obrecht, Christian Bisang, Sophie Barthélémy, Alexander Lederer, Eric Chevalier
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Patent number: 8716515Abstract: The present invention relates to a process for the preparation of polyether ester polyols starting from fatty acid esters and starter compounds having Zerewitinoff-active hydrogen atoms, and to their use in the production of solid or foamed polyurethane materials.Type: GrantFiled: October 15, 2009Date of Patent: May 6, 2014Assignee: Bayer MaterialScience AGInventors: Klaus Lorenz, Reinhard Albers, Frank Otto
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Patent number: 8716242Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), and pharmaceutically acceptable salts thereof, with Xaa 1-Xaa 16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and prolonged half-lives in vivo and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: December 4, 2009Date of Patent: May 6, 2014Assignee: Polyphor AGInventors: Sophie Barthélémy, Christian Bisang, Frank Otto Gombert, Alexander Lederer, Daniel Obrecht, Barbara Romagnoli, Jürg Zumbrunn, Tobias Remus, Guillaume Lemercier