Patents by Inventor Frank P. T. Baaijens

Frank P. T. Baaijens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF MANUFACTURING A TISSUE-ENGINEERED PROSTHESIS
    Publication number: 20130217128
    Abstract: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
    Type: Application
    Filed: January 8, 2013
    Publication date: August 22, 2013
    Applicants: TECHNISCHE UNIVERSITEIT EINDHOVEN, Universitaet Zuerich
    Inventors: Carlijn V.C. BOUTEN, Anita MOL, Marcel C.M. RUTTEN, Simon P. HOERSTRUP, Frank P.T. BAAIJENS
  • Method of manufacturing a tissue-engineered prosthesis
    Patent number: 8399243
    Abstract: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: March 19, 2013
    Assignees: Universitaet Zuerich, Technische Universiteit Eindhoven
    Inventors: Carlijin V. C. Bouten, Anita Mol, Marcel C. M. Rutten, Simon P. Hoerstrup, Frank P. T. Baaijens
  • Method of Manufacturing a Tissue-Engineered Prosthesis
    Publication number: 20080145920
    Abstract: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
    Type: Application
    Filed: February 1, 2006
    Publication date: June 19, 2008
    Applicants: UNIVERSITAET ZUERICH, TECHNISCHE UNIVERSITAT EINDHOVEN
    Inventors: Carlijn V.C. Bouten, Anita Mol, Marcel C.M. Rutten, Simon P. Hoerstrup, Frank P.T. Baaijens