Abstract: Disclosed are cationic lipids which are compounds of Formula (I?). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Abstract: An infusion line gas removal device and process for its fabrication and use is disclosed herein. The gas removal device includes a gas permeable tubing coupled between first and second couplers, and an impermeable tubing shield encasing the gas permeable tubing between the first and second couplers. The impermeable tubing shield is larger in diameter than the gas permeable tubing and comprises at least one vent and a plurality of supports, the plurality of supports being between the tubing shield and the gas permeable tubing and configured to support the gas permeable tubing within the impermeable tubing shield in a fixed position between the first and second couplers and facilitate passage of gas from the gas permeable tubing to the at least one vent.

Abstract: The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the UMIs include both physical UMIs and virtual UMIs. In some implementations, the unique molecular index sequences include non-random sequences. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.

Abstract: A camera is used to capture image data of representations of a physical environment. Planes and surfaces are determined from a representation. The planes and the surfaces are analyzed using relationships there between to obtain shapes and depth information for available spaces within the physical environment. Locations of the camera with respect to the physical environment are determined. The shapes and the depth information are analyzed using a trained neural network to determine items fitting the available spaces. A live camera view is overlaid with a selection from the items to provide an augmented reality (AR) view of the physical environment from an individual location of the locations. The AR view is enabled so that a user can port to a different location than the individual location by an input received to the AR view while the selection from the items remains anchored to the individual location.

Abstract: The present invention refers to oligonucleotides comprising 10 to 25 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with mRNA of angiotensin-converting enzyme 2 (ACE2) of SEQ ID NO.1 and/or with pre-mRNA of ACE2 of SEQ ID NO.2 resulting in a reduction of the level of ACE2, ACE2 mRNA, ACE2 pre-mRNA or a combination thereof of 30 to 99% compared to an untreated control. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide. The oligonucleotide and the pharmaceutical composition are used in a method of preventing and/or treating a viral disease.

Abstract: A system is provided for automatic identification and annotation of objects in a point cloud in real time. The system can automatically annotate a point cloud that identifies coordinates of objects in three-dimensional space while data is being collected for the point cloud. The system can train models of physical objects based on training data, and apply the models to point clouds that are generated by various point cloud generating devices to annotate the points in the point clouds with object identifiers. The solution of automatically annotated point cloud can be used for various applications, such as blueprints, map navigation, and determination of robotic movement in a warehouse.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: A cloud-based security system includes a plurality of enforcement nodes connected to one another; a central authority connected to the plurality of enforcement nodes; and a Data Loss Prevention (DLP) service executed between the plurality of enforcement nodes, wherein the DLP service includes one or more DLP rules based on one or more DLP engines for a tenant, and wherein, for the DLP service, a first enforcement node is configured to monitor traffic of a user of the tenant, detect a DLP rule violation based on the one or more DLP rules, and forward DLP incident information to a second enforcement node, and the second enforcement node is configured to transmit the DLP incident information to a server for the tenant, including both DLP triggering content that cause the DLP rule violation and DLP scan metadata.

Abstract: The disclosure relates to on-ear headphones comprising at least one ear-cushion, the at least one ear-cushion defining an ear-surface configured to interface with a user's ear when the headphones are worn by the user, the ear-surface comprising a perforated area, the perforated area comprising a plurality of staggered elongated perforations.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: A cloud-based security system includes a plurality of enforcement nodes connected to one another; a central authority connected to the plurality of enforcement nodes; and a Data Loss Prevention (DLP) service executed between the plurality of enforcement nodes, wherein the DLP service includes one or more DLP rules based on one or more DLP engines for a tenant, and wherein, for the DLP service, a first enforcement node is configured to monitor traffic of a user of the tenant, detect a DLP rule violation based on the one or more DLP rules, and forward DLP incident information to a second enforcement node, and the second enforcement node is configured to transmit the DLP incident information to a server for the tenant, including both DLP triggering content that cause the DLP rule violation and DLP scan metadata.

Abstract: Disclosed is a flow heater for new forms of vehicles. The flow heater comprises a passageway for liquid, a heating source, a swing mechanism arranged in the passageway, and a sensor for detecting a position of the swing mechanism.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: This invention generally relates to commissioning in Zigbee Light Link (ZLL) networks. The proposed solution takes advantage of the existing Touchlink procedure in order to enable a controller device joining a ZLL network without having to Touchlink with every single lighting devices comprised in the ZLL network. This way, the one or more lighting devices of the ZLL network may be directly controlled by the newly joined controller device after a single Touchlink thanks to the introduction of a commissioning device. The commissioning device may be configured to provide specific joining information and binding information to the controller device. Further, a timer in the commissioning device may be triggered to lapse after a given period of time where the controller may be disconnected from the ZLL network.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: A connector assembly includes a first connector, a second connector and a metal housing. The first connector includes an insulating body, conductive terminals, and a first cable, each conductive terminal having a contact portion. The second connector includes a sub-circuit board and a second cable connected to the sub-circuit board, the sub-circuit board having a butting end facing the first connector, and gold fingers being distributed on the surface of the butting end. The metal housing is provided with an insertion hole, the insertion hole having a front insertion opening at the front end of the metal housing and a rear insertion opening at the rear end of the metal housing. The first connector is inserted into the insertion hole from the front insertion opening, and the second connector is inserted into the insertion hole from the rear insertion opening. The contact portions are in contact with the gold fingers.

Abstract: We disclose multiband receivers for millimeter-wave devices, which may have reduced size and/or reduced power consumption. One multiband receiver comprises a first band path comprising a first passive mixer configured to receive a first input RF signal having a first frequency and to be driven by a first local oscillator signal having a frequency about ? the first frequency; a second band path comprising a second passive mixer configured to receive a second input RF signal having a second frequency and to be driven by a second local oscillator signal having a frequency about ? the second frequency; and a base band path comprising a third passive mixer configured to receive intermediate RF signals during a duty cycle and to be driven by a third local oscillator signal having a frequency about ? the first frequency or about ? the second frequency during the duty cycle.

Abstract: A connector assembly includes a first connector, a second connector and a metal housing. The first connector includes an insulating body, conductive terminals, and a first cable, each conductive terminal having a contact portion. The second connector includes a sub-circuit board and a second cable connected to the sub-circuit board, the sub-circuit board having a butting end facing the first connector, and gold fingers being distributed on the surface of the butting end. The metal housing is provided with an insertion hole, the insertion hole having a front insertion opening at the front end of the metal housing and a rear insertion opening at the rear end of the metal housing. The first connector is inserted into the insertion hole from the front insertion opening, and the second connector is inserted into the insertion hole from the rear insertion opening. The contact portions are in contact with the gold fingers.

Abstract: We disclose a receiver circuit which may be used in mm-wave devices. The receiver circuit comprises a transimpedance amplifier comprising PMOS and NMOS transistors, wherein the back gate voltages provided to the transistors may be adjusted. By adjusting the back gate voltages during device operation, structural variations and temperature variations in the threshold voltages of the transistors may be minimized and the gain compression tolerance of the receiver circuit may be increased.