Patents by Inventor Franklin Kent Hamra

Franklin Kent Hamra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF GENETICALLY ENGINEERED ANIMALS BY CRISPR/CAS9 GENOME EDITING IN SPERMATOGONIAL STEM CELLS
    Publication number: 20190134227
    Abstract: The present disclosure provides methods and compositions for the production of genetically engineered animals, such as mice, by genomic editing of the spermatogonial stem cells, such as by using the CRISPR/Cas9 gene editing system. Also provided are methods of studying gene function and creating disease models.
    Type: Application
    Filed: April 5, 2017
    Publication date: May 9, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventor: Franklin Kent HAMRA
  • Production and use of rat spermatogonial stem cell lines
    Patent number: 9474254
    Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: October 25, 2016
    Assignee: Board of Regents of the University of Texas System
    Inventor: Franklin Kent Hamra
  • PRODUCTION AND USE OF RAT SPERMATOGONIAL STEM CELL LINES
    Publication number: 20140344963
    Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 20, 2014
    Applicant: Board of Regents of The University of Texas System
    Inventor: Franklin Kent Hamra
  • Production and use of rat spermatogonial stem cell lines
    Patent number: 8735156
    Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: May 27, 2014
    Inventor: Franklin Kent Hamra
  • PRODUCTION AND USE OF RAT SPERMATOGONIAL STEM CELL LINES
    Publication number: 20110302666
    Abstract: A spermatogonial stem cell line that is derived from testes rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.
    Type: Application
    Filed: December 1, 2009
    Publication date: December 8, 2011
    Inventor: Franklin Kent Hamra
  • Transgenic rats and spermatogonial stem cells
    Patent number: 7491866
    Abstract: A transgenic rat expresses a gene of interest, such as EGFP, exclusively in the germ cells of both males and females. From such a transgenic rat one can isolate a line of spermatogonial stem cells, which can renew and proliferate in culture.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: February 17, 2009
    Assignee: Board of Regents University of Texas System
    Inventors: Robert E. Hammer, Franklin Kent Hamra, Jennifer T. Cronkhite