Abstract: A device and a method for computer-aided processing of data are disclosed, the method including: providing configuration data of an application, determining a first application identification, wherein the first application identification is assigned to the application, determining a configuration identification, wherein the configuration identification is assigned to the configuration data of the application, individualizing the data by means of a second application identification, wherein the second application identification is determined using the first application identification and the configuration identification.

Abstract: A device and a method (300A) for computer-aided processing of data are disclosed, wherein the method (300A) includes: providing configuration data of an application (in 302), determining a first application identification (in 304), wherein the first application identification is assigned to the application, determining a configuration identification (in 306), wherein the configuration identification is assigned to the configuration data of the application, individualizing the data by means of a second application identification (in 310), wherein the second application identification is determined using the first application identification and the configuration identification (in 308).

Abstract: The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from MHC molecules of at least one other subset in at least one of the putative MHC binding peptide, an MHC alpha chain and an MHC beta chain, and loading said MHC molecules with an MHC binding peptide by (i) refolding of the MHC alpha chain and beta chain peptides in presence of said MHC binding peptide or (ii) by peptide exchange or loading with an unlabelled MHC binding peptide in the absence of any labelled MHC binding peptide, (b) taking of at least one sample from each subset, and (c) determining loading efficiency for the sample of step (b).

Abstract: This invention concerns an oligomeric receptor-ligand pair member in general and an oligomeric MHC-peptide complex in particular and a method of labeling, detecting and separating mammalian T cells according to the specificity of their antigen receptor by use of the oligomer. The invention further concerns a method of targeting the oligomeric receptor-ligand pair member complexes to target molecules of the surface of a target cell in order to present antigens on the target cell. The invention further concerns related pharmaceutical and diagnostic compositions and processes.

Abstract: The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from MHC molecules of at least one other subset in at least one of the putative MHC binding peptide, an MHC alpha chain and an MHC beta chain, and loading said MHC molecules with an MHC binding peptide by (i) refolding of the MHC alpha chain and beta chain peptides in presence of said MHC binding peptide or (ii) by peptide exchange or loading with an unlabelled MHC binding peptide in the absence of any labelled MHC binding peptide, (b) taking of at least one sample from each subset, and (c) determining loading efficiency for the sample of step (b).

Abstract: The invention demonstrates an improved choice of biotinylation peptide to be used in a combination or fusion with an MHC molecule for immobilizing or multimerising such MHC molecules for a variety of purposes.

Abstract: The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different MHC molecules at high yields for each molecule.

Abstract: A single-use mixer or homogenizer is provided that includes a container provided with a lid which is provided as a compression element (29) for substances (45) in the container (1). The compression element (29) is rotatably arranged in relation to the container (1). The substances (45) are pressed and ground through the sieve (13) into the collecting chamber (27) by the rotation of the compression element (29), and can be removed by a pipette (43) which passes through both the compression element (29) and the cover on the sieve (13).

Abstract: This invention concerns an oligomeric receptor-ligand pair member in general and an oligomeric MHC-peptide complex in particular and a method of labeling, detecting and separating mammalian T cells according to the specificity of their antigen receptor by use of the oligomer. The invention further concerns a method of targeting the oligomeric receptor-ligand pair member complexes to target molecules of the surface of a target cell in order to present antigens on the target cell. The invention further concerns related pharmaceutical and diagnostic compositions and processes.

Abstract: An optical detection device is provided for analyzing analytes in a liquid suspension or solution that can detect and process a large number of wavelengths of incident and fluorescent light simultaneously, which is small in size and can be easily adapted to different investigation requirements. The optical detection device may include a light supplying device, an analyte handling device, a light directing device, and a detector integrated on planar substrate devices, respectively. A plurality of optical waveguides are integrated in the substrate devices to direct light emitted by the light supplying device through the different sections of the optical detector to the detector. The analyte handling device may include an analyte channel for the liquid flow of the analyte suspension or solution and an analyte sorting device comprising several sorting channels.

Abstract: This invention concerns an oligomeric receptor-ligand pair member complex in general and an oligomeric MHC-peptide complex in particular and a method of labeling, detecting and separating mammalian T cells according to the specificity of their antigen receptor by use of the oligomer. The invention further concerns a method of targeting the oligomeric receptor-ligand pair member complexes to target molecules of the surface of a target cell in order to present antigens on the target cell. The invention further concerns related pharmaceutical and diagnostic compositions and processes.

Abstract: The present invention relates to an MHC binding polymer suitable for the oligomerisation of individual MHC monomers. The MHC binding polymer comprises a first segment and a second segment, wherein the first segment comprises a peptide capable of binding in a binding groove of an MHC molecule, and wherein the second segment comprises a linking segment and a recognition site for coupling the MHC binding polymer with a specific partner. The linking segment is a polymer with a length of at least 10 Angstrom in its native conformation. Further it relates to an MHC oligomer containing such MHC binding polymers. Individual functional MHC complex monomers are oligomerised via their peptides bound in the peptide binding groove of the complex. Moreover, it relates to a method of making such MHC binding polymer and oligomer and various methods using the same.

Abstract: The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from MHC molecules of at least one other subset in at least one of the putative MHC binding peptide, an MHC alpha chain and an MHC beta chain, and loading said MHC molecules with an MHC binding peptide by (i) refolding of the MHC alpha chain and beta chain peptides in presence of said MHC binding peptide or (ii) by peptide exchange or loading with an unlabelled MHC binding peptide in the absence of any labelled MHC binding peptide, (b) taking of at least one sample from each subset, and (c) determining loading efficiency for the sample of step (b).

Abstract: The invention discloses MHC oligomers and methods for making the same comprising at least two functional MHC complexes having a peptide binding groove, each MHC complex having a peptide bound in the peptide binding groove of the MHC complex, wherein each peptide has a modification which allows highly specific oligomerisation of the functional MHC complexes through a core structure.

Abstract: The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different MHC molecules at high yields for each molecule.

Abstract: A single-use fractionating device (53) is provided including a laboratory test container (43) for the substances to be fractioned (55), and a receiving container (27) for receiving fractioned substances (57). The containers (27, 43) are interconnected by the fractionating device (53). For the fractionating process, the two containers (27, 43) or the fractionating mechanism (1) with the laboratory container (43) and the fractionating mechanism body (11) with the receiving container (27) are rotated relative to each other. The product to be fractioned is hermetically sealed from the environment during the entire fractionating process.

Abstract: A device for extracting and fragmenting substances, especially infectious or malodorous substances, in a laboratory test vessel (3) is provided. The device includes a processing tool (11) and a stirrer element (33). An interior of the laboratory test vessel (3) is subdivided by a sieve (59) into a collection chamber and a processing chamber. The sieve (59) prevents parts of the substances having a defined rain size from reaching the collection chamber (73). A sample can be taken from the collection chamber using a pipette (45) which is passed through the stirrer element (33) and the sieve (59).

Abstract: An optical detection device is provided for analyzing analytes in a liquid suspension or solution that can detect and process a large number of wavelengths of incident and fluorescent light simultaneously, which is small in size and can be easily adapted to different investigation requirements. The optical detection device may include a light supplying device, an analyte handling device, a light directing device, and a detector integrated on planar substrate devices, respectively. A plurality of optical waveguides are integrated in the substrate devices to direct light emitted by the light supplying device through the different sections of the optical detector to the detector. The analyte handling device may include an analyte channel for the liquid flow of the analyte suspension or solution and an analyte sorting device comprising several sorting channels.

Abstract: A device for extracting and fragmenting substances, especially infectious or malodorous substances, in a laboratory test vessel (3) is provided. The device includes a processing tool (11) and a stirrer element (33). An interior of the laboratory test vessel (3) is subdivided by a sieve (59) into a collection chamber and a processing chamber. The sieve (59) prevents parts of the substances having a defined rain size from reaching the collection chamber (73). A sample can be taken from the collection chamber using a pipette (45) which is passed through the stirrer element (33) and the sieve (59).

Abstract: A device for extracting and fragmenting substances, especially infectious or malodorous substances, in a laboratory test vessel (3) is provided. The device includes a processing tool (11) and a stirrer element (33). An interior of the laboratory test vessel (3) is subdivided by a sieve (59) into a collection chamber and a processing chamber. The sieve (59) prevents parts of the substances having a defined rain size from reaching the collection chamber (73). A sample can be taken from the collection chamber using a pipette (45) which is passed through the stirrer element (33) and the sieve (59).