Abstract: The use of certain 6-arylpyrazolo[3,4-d]pyrimidin-4-ones, 2 arylquinazolin-4-ones, 2-arylpurin-6-ones and 2-arylpyrido[3,2-d]pyrimidin-4-ones, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing either entity, for the manufacture of a medicament for the curative or prophylactic treatment of erectile dysfunction in a male animal, including man; a pharmaceutical composition for said treatment; and a method of said treatment of said animal with said pharmaceutical composition or with said either entity.

Abstract: The present invention provides an intra-oral anchorage which comprises a flexible belt that extends around and between the teeth of a patient. The belt has locking means fixed thereon to receive a free end portion of the belt and lock said portion against retraction therefrom. The locking means is in the form of a buckle. The intra-oral anchorage of the present invention can be used to hold a jaw in a fixed position, in the case of a broken jaw for example. It offers ease of application and therefore a reduction in the cost of surgery as well as eliminating the risk of “needle stick” injury inherent with cutting and bending multiple ends of wire. It causes less gum damage in placement and removal, which is similarly easier, faster and less uncomfortable for the patient.

Abstract: 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-one compounds which are selective inhibitors of cGMP PDE are useful in the treatment of erectile dysfunction (impotence) in male animals, including man.

Abstract: 4-aminoquinazoline derivatives which are selective inhibitors of cGMP PDE are useful in the treatment of erectile dysfunction (impotence) in male animals, including man.

Abstract: A method of treating male erectile dysfunction comprising administering to a male human a pyrimidine compound of formula I.