Abstract: The present invention relates to oral care compositions which provide a means to deliver actives which are useful in the prevention, treatment and/or management of dental and related tissue conditions, including dental caries, dental cavities, microbial flora, tartar, periodontal and related gum disease. In addition, the present invention may be used in the healthy maintenance of teeth and gums. Further aspects of the present invention are related to the present compositions being useful to whiten teeth and otherwise favorably impact the cosmetic appeal of the teeth and gums of a subject or patient. A further aspect of the present invention is directed to the inclusion of effective amounts of colostrum in dental care compositions for the unexpectedly high efficacy such formulations provide in inhibiting, reducing or otherwise preventing microbial growth, dental caries, plaque, cavities and gum disease, including periodontal disease.