Abstract: A digital compensation system for a radio frequency (RF) power amplifier module is disclosed. The digital compensation system includes an RF power amplifier having a first input, a first output, and a first bias input, wherein the RF power amplifier is configured to receive an RF signal at the first input and generate an amplified version of the RF signal at the first output. The digital compensation system also includes compensation circuitry coupled between the first input and the first output and a bias output coupled to the RF power amplifier, wherein the compensation circuitry is configured, in response to the RF signal, to generate or adjust a bias signal at the first bias input to correct dynamic bias errors caused by amplification variations that have time constants.

Abstract: Provided herein is a method for detecting the presence of clade variants in the COVID-19 virus in a human sample and/or an environmental sample. Samples are processed to obtain total RNA. The RNA is used as a template in a combined reverse transcription and amplification reaction to obtain fluorescent COVID-19 virus amplicons. These amplicons are hybridized on a microarray with nucleic acid probes having sequences that discriminate among the various clade variants. The microarray is imaged to detect the clade variant. Also provided is a method of distinguishing each clade variant from others by generating an intensity distribution profile from the image, which is unique to each of the clade variants.

Abstract: The present disclosure, in some aspects, provides devices useful for determining a target nucleic acid profile of a sample. The device comprises an enrichment module, a reaction module and a nucleic acid sequencer. In other aspects, the present disclosure provides kits, components and compositions (such as consumables) of the devices and methods of using the devices described herein.

Abstract: The present disclosure, in some aspects, is directed to methods of nucleic acid enrichment using high affinity capture probes comprising one or more nucleotide analogs and uses thereof. For example, in another aspect, provided herein are methods of enriching a target nucleic acid if present in a sample. In another aspect, provided herein are methods of detecting if a target nucleic acid is in a sample. In another aspect, the present disclosure is directed to uses, kits, and compositions of the methods described herein.

Abstract: The present disclosure, in some aspects, is directed to methods of determining an infection profile of an individual, wherein the infection profile is based on a host response profile and a pathogen profile of the individual. In other aspects, the present disclosure is directed to uses (e.g., methods of treatment, treatment selection, patient selection), kits, and compositions of the methods described herein.

Abstract: Methods and systems for controlling access to content are described. The method may include detecting, at a client electronic device, the presence of a beacon device signal emitted from a beacon device. The method may further include determining, based on the beacon device signal, whether the content is accessible from the client electronic device. The method may also include, in response to determining that the content is accessible from the client electronic device, providing access to the content at the client electronic device.

Abstract: An arm brace for a pistol is provided having removable grip panels. The arm brace with removable grip panels comprises a grip portion defining apertures for connecting to a pistol frame as a replacement grip. The arm brace further comprises a frame extending rearward from a lower end of the grip portion. Further, a concave wrist support element connected to the frame and configured to receive a user's wrist while the user's hand associated with the wrist is gripping the pistol.

Abstract: A print engine includes a printer module for printing image data in a plurality of different print modes, wherein each print mode has an associated line print time. A data interface receives image data and associated metadata for a print job from a pre-processing system, the metadata including print mode metadata. A digital memory stores a plurality of pulse timing functions, each pulse timing function corresponding to one of the line print times associated with the plurality of print modes. A metadata interpreter interprets the metadata and determines the print mode to be used to print the image data. A printer module controller controls the printer module to print the image data using the pulse timing function corresponding to the line print time associated with the print mode, wherein each light source is activated for a pulse count corresponding to a pixel code value of an associated image pixel.

Abstract: A print engine includes a printer module for printing image data in a plurality of different print modes, wherein each print mode has an associated line print time. A data interface receives image data and associated metadata for a print job from a pre-processing system, the metadata including print mode metadata. A digital memory stores a plurality of pulse timing functions, each pulse timing function corresponding to one of the line print times associated with the plurality of print modes. A metadata interpreter interprets the metadata and determines the print mode to be used to print the image data. A printer module controller controls the printer module to print the image data using the pulse timing function corresponding to the line print time associated with the print mode, wherein each light source is activated for a pulse count corresponding to a pixel code value of an associated image pixel.

Abstract: A method is described for calibrating a linear printhead including an array of light sources. A test target is printed by activating the light sources in the printhead in accordance with digital image data for the test target, wherein a current value for each light source is controlled responsive to an initial set of current control parameters. A digital image capture system is used to capture an image of the printed test target, and the captured digital image is analyzed to determine an estimated exposure gain error for each light source. An updated set of current control parameters is then determined which is adapted to compensate for the estimated exposure gain errors.

Abstract: A print engine is adapted to print image data from a plurality of pre-processing systems that supply image data at different image resolutions and halftoning states. A data interface receives the image data and associated metadata including an image resolution parameter and a halftone state parameter. A metadata interpreter interprets the metadata and determines image processing operations that are required to prepare the image data for printing using a printer module. A resolution modification processor module processes the image data to modify its resolution if the metadata interpreter determines that the image resolution of the image data does not match the printer resolution. A halftone processor module processes the image data by applying a halftoning operation if the metadata interpreter determines that the image data is not in an appropriate halftoning state.

Abstract: A programmable amplifier includes an amplifier, an input capacitor, a feedback circuit, and a high-pass filter circuit. The amplifier has an input coupled to the input capacitor for receiving an input signal. The feedback circuit includes multiple feedback capacitors of differing capacitance values that are each selectively coupled between the output of the amplifier and the input of the amplifier using multiple first switches. The high-pass filter circuit includes multiple switched capacitors of differing capacitance values that are each selectively coupled between the amplifier output and a ground node using multiple second switches. The first switches are configured to be selectively switched on for activating at least one feedback capacitor to adjust a gain of the amplifier, while the second switches are configured to be selectively switched at a first and second phase of a clock signal to adjust a high-pass cutoff frequency of the amplifier independently of how the gain is adjusted.

Abstract: Adding new nodes to a graph diagram. A set of one or more new nodes is identified from a graph to be added to an existing graph diagram. A set of one or more anchor candidate nodes are identified in the graph that are coupled to the nodes in the set of one or more new nodes. One of the nodes in the set of one or more anchor candidate nodes is selected as an anchor node. An automatic graph diagram layout of the anchor node and new nodes that are to be coupled to the anchor node is performed to create a disjoint graph diagram. A spatial offset from the anchor node to each of the new nodes coupled to the anchor node in the disjoint graph diagram is identified. Each of the new nodes is added to the existing graph diagram while maintaining the identified spatial offsets.

Abstract: The present application provides a reusable microarray comprising a plurality of immobilized oligonucleotide probes each having one or more nucleotides that are resistant to cleavage. The microarray is useful for analyzing nucleic acids, including single nucleotide polymorphisms (SNPs) by extension or ligation assays. The microarray can be reused by treatment that cleaves non-resistant extension or ligation products on the free termini of the oligonucleotide probes.

Abstract: A programmable amplifier includes an amplifier, an input capacitor, a feedback circuit, and a high-pass filter circuit. The amplifier has an input coupled to the input capacitor for receiving an input signal. The feedback circuit includes multiple feedback capacitors of differing capacitance values that are each selectively coupled between the output of the amplifier and the input of the amplifier using multiple first switches. The high-pass filter circuit includes multiple switched capacitors of differing capacitance values that are each selectively coupled between the amplifier output and a ground node using multiple second switches. The first switches are configured to be selectively switched on for activating at least one feedback capacitor to adjust a gain of the amplifier, while the second switches are configured to be selectively switched at a first and second phase of a clock signal to adjust a high-pass cutoff frequency of the amplifier independently of how the gain is adjusted.

Abstract: Adding new nodes to a graph diagram. A set of one or more new nodes is identified from a graph to be added to an existing graph diagram. A set of one or more anchor candidate nodes are identified in the graph that are coupled to the nodes in the set of one or more new nodes. One of the nodes in the set of one or more anchor candidate nodes is selected as an anchor node. An automatic graph diagram layout of the anchor node and new nodes that are to be coupled to the anchor node is performed to create a disjoint graph diagram. A spatial offset from the anchor node to each of the new nodes coupled to the anchor node in the disjoint graph diagram is identified. Each of the new nodes is added to the existing graph diagram while maintaining the identified spatial offsets.

Abstract: A print engine is adapted to print image data from a plurality of pre-processing systems that supply image data at different image resolutions and halftoning states. A data interface receives the image data and associated metadata including an image resolution parameter and a halftone state parameter. A metadata interpreter interprets the metadata and determines image processing operations that are required to prepare the image data for printing using a printer module. A resolution modification processor module processes the image data to modify its resolution if the metadata interpreter determines that the image resolution of the image data does not match the printer resolution. A halftone processor module processes the image data by applying a halftoning operation if the metadata interpreter determines that the image data is not in an appropriate halftoning state.

Abstract: Adding new nodes to a graph diagram. A set of one or more new nodes is identified from a graph to be added to an existing graph diagram. A set of one or more anchor candidate nodes are identified in the graph that are coupled to the nodes in the set of one or more new nodes. One of the nodes in the set of one or more anchor candidate nodes is selected as an anchor node. An automatic graph diagram layout of the anchor node and new nodes that are to be coupled to the anchor node is performed to create a disjoint graph diagram. A spatial offset from the anchor node to each of the new nodes coupled to the anchor node in the disjoint graph diagram is identified. Each of the new nodes is added to the existing graph diagram while maintaining the identified spatial offsets.

Abstract: Adding a new disjoint graph diagram to an existing graph diagram. A set of one or more new nodes from a graph to be added to a first graph diagram are identified. An automatic graph diagram layout of the set of one or more new nodes is performed creating a second graph diagram. The first graph diagram is aligned along a first axis with the second graph diagram Nodes in the first graph diagram that are at least partially between a first point and a second point of boundaries of the second graph diagram are identified. A boundary is created around the nodes in the first graph diagram that are between the first and second points. The second graph diagram is moved along a second axis toward the boundary to create a combined graph diagram.

Abstract: Adding new nodes to a graph diagram. A set of one or more new nodes is identified from a graph to be added to an existing graph diagram. A set of one or more anchor candidate nodes are identified in the graph that are coupled to the nodes in the set of one or more new nodes. One of the nodes in the set of one or more anchor candidate nodes is selected as an anchor node. An automatic graph diagram layout of the anchor node and new nodes that are to be coupled to the anchor node is performed to create a disjoint graph diagram. A spatial offset from e anchor node to each of the new nodes coupled to the anchor node in the disjoint graph diagram is identified. Each of the new nodes is added to the existing graph diagram while maintaining the identified spatial offsets.