Abstract: Provided herein are devices, systems, and methods for providing controlled delivery of a therapeutic substance during a surgical procedure, the devices and systems including a base, a frame having a proximal end and a distal end attached to the base, an injection subassembly including a plunger shaft, a relative motion subassembly including a lever plate, and a fastener configured to connect the plunger shaft of the injection subassembly and the lever plate of the relative motion subassembly.

Abstract: Provided herein are devices, systems, and methods for providing controlled delivery of a therapeutic substance during a surgical procedure, the devices and systems including a base, a frame having a proximal end and a distal end attached to the base, an injection subassembly including a plunger shaft, a relative motion subassembly including a lever plate, and a fastener configured to connect the plunger shaft of the injection subassembly and the lever plate of the relative motion subassembly.

Abstract: Provided herein are devices, systems, and methods for providing controlled delivery of a therapeutic substance during a surgical procedure.

Abstract: A myocyte culture pacing apparatus operating in conjunction with a standard culture dish that permits long term maintenance of cultured myocyte cells over a period of several weeks The device includes a base unit for receiving the culture dish, and an electrode unit for placement atop the culture dish which can receive the cover of the culture dish. The electrode unit has a first and a second planar conductive electrodes extending into each well of the culture dish. The electrodes are planar and extend across the width of the well and are connected to electrical connector for connection to an external electronic unit, which supplies the a variety of electrical pulse regimes to pace the myocyte cultures. The electronic unit permits the type, frequency, duration, voltage and the current of the pulses to be varied in accordance with the desired pacing regime.

Abstract: A customized surgical fixture (400) is formed by scanning a body to form a three-dimensional image of the body, and then identifying in the image a target (310) in the body, and mounting points or structures (330) on the body. A model, such as a computer solid model, of the fixture (400) is specified in accordance with the locations of the target (310) and mounting structures (330) or points. The fixture (400) is formed in accordance with the model of the fixture (400), for example using a rapid prototyping and tooling machine. When attached to the body, the fixture (400) can be used to guide a surgical instrument (610) into the body, for example, by using a mechanical guide (600) attached to the fixture (400) or using a remote sensing device (1300) that tracks the relative position of the customized fixture (400) and the surgical instrument.