Patents by Inventor Frederick N. Miller

Frederick N. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for automated rolling leukocyte velocity measurement in vivo
    Patent number: 6473698
    Abstract: A time-varying image of a circulating venue containing a flow of particles is generated by imaging using a video camera and a digital frame grabber. Spatio-temporal intensity gradients within each of the images are generated. Particles are then identified within the images. A particle is matched with a corresponding identical particle from other images using, for example, a heuristic equation that measures similarity of shape, size, and position. The distance of translation of the matched particle from one image to another is determined. Leukocyte velocity is determined by dividing the translation distance by the time differential between the images. The first five statistical moments of frequency distribution of the velocity may also be determined.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: October 29, 2002
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Thomas A. Albert, Frederick N. Miller
  • Micro lysis-analysis process to measure cell characteristics
    Patent number: 6174698
    Abstract: A micro lysis and analysis process applying precise quantities of focused energy, such as light energy, to a precise microscopic area of a very small cell sample to activate an energy sensitive agent, such as a fluorescing agent, which permits measurement of cell fragility providing a means for determining the sensitivity of cells to particular chemicals, drugs, and/or diseases and the susceptibility and/or exposure of the cells to same.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: January 16, 2001
    Assignee: Micro-Med, Inc.
    Inventor: Frederick N. Miller
  • Micro lysis-analysis process to measure cell characteristics and diagnose diseases
    Patent number: 5955295
    Abstract: A micro lysis and analysis process applying precise quantities of focused energy, such as light energy, to a precise microscopic area of a very small cell sample to activate an energy sensitive agent, such as a fluorescing agent, which permits measurement of cell fragility providing a means for determining the sensitivity of cells to particular chemicals, drugs, and/or diseases and the susceptibility and/or exposure of the cells to same.
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: September 21, 1999
    Assignee: Micro-Med, Inc.
    Inventor: Frederick N. Miller
  • Microphoto lysis-anlaysis process to measure cell characteristics
    Patent number: 5610027
    Abstract: A method of determining cell membrane strength is disclosed, using focused light of selected frequency and energy density. The method is also useful in diagnosing the presence of certain diseases in cells, by comparing the membrane strength of cells exposed to cell-characteristic altering drugs to the membrane strength of a control group of cells.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: March 11, 1997
    Assignee: Micro-Med, Inc.
    Inventor: Frederick N. Miller
  • Micro lysis-analysis process to measure cell characteristics and diagnose diseases
    Patent number: 5532139
    Abstract: A microphotolysis and microphotoanalysis process applying precise quantities of focused light energy to a precise microscopic area of a very small cell sample to activate a chemical agent which permits measurement of cell fragility.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: July 2, 1996
    Assignee: Micro-Med, Inc.
    Inventor: Frederick N. Miller