Patents by Inventor Frederick W. Gluck

Frederick W. Gluck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8563269
    Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: October 22, 2013
    Assignee: CytomX Therapeutics, Inc.
    Inventors: Nancy E. Stagliano, James W. West, Kathryn Kamath, Paul H. Bessette, Frederick W. Gluck, Jason Sagert, Patrick Daugherty
  • Publication number: 20120207756
    Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Inventors: Nancy E. Stagliano, James W. West, Kathryn Kamath, Paul H. Bessette, Frederick W. Gluck, Jason Sagert, Patrick Daugherty
  • Publication number: 20120149061
    Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: NANCY E. STAGLIANO, JAMES W. WEST, KATHRYN KAMATH, PAUL H. BESSETTE, FREDERICK W. GLUCK, JASON SAGERT, PATRICK DAUGHERTY
  • Publication number: 20110137018
    Abstract: A system for sorting and trapping magnetic target species includes a microfluidic chamber designed to receive and then temporarily hold magnetic particles in place within the module. A pre-processing module may mix a sample and magnetic particles to cause certain species in the sample to be labeled. The micorfluidic chamber may include a mechanism to move magnetic particles within the chamber. A post-processing module or the microfluidic chamber may be used to separate the labeled species from the magnetic particles by adding a release reagent. The magnetic particles and/or their payloads may be released and separately collected at an outlet of the chamber or the post-processing module.
    Type: Application
    Filed: April 16, 2009
    Publication date: June 9, 2011
    Applicant: CYNVENIO BIOSYSTEMS, INC.
    Inventors: David A. Chang-Yen, Jafar Darabi, Yanting Zhang, Paul Pagano, Frederick W. Gluck