Patents by Inventor Frederick W. Holly

Frederick W. Holly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic octapeptide analogs of neurotensin
    Patent number: 4439359
    Abstract: There are disclosed cyclic octapeptide analogs of the tridecapeptide, neurotensin.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Frederick W. Holly, deceased, Marcia E. Christy, Kenneth L. Shepard, Robert G. Strachan, Sandor L. Varga, Daniel F. Veber
  • Somatostatin analogs
    Patent number: 4162248
    Abstract: Somatostatin analogs having the structural formula:Cyclo[(X).sub.j -(A).sub.k -(B).sub.1 -Phe-Phe-(D- or L-)Trp-Lys-Thr-Phe-Thr-(C).sub.m ]WhereinX is ##STR1## and n=0 to 4; A is Lys, (.epsilon.-INOC) Lysine;B is Asn, Ala, .alpha.-aminobutyric acid;C is Ser, Gly;J, k, l and m are 0 to 1; with the proviso that j, k, l, and m are not all 1 and not all 0,Wherein the ring formed by the peptide backbone contains 24 to 33 atoms and the pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, decreasing gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert G. Strachan, William J. Paleveda, Daniel F. Veber, Frederick W. Holly
  • Somatostatin analogs
    Patent number: 4161521
    Abstract: Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: July 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Frederick W. Holly, Robert G. Strachan, William J. Paleveda, Ruth F. Nutt, Ralph F. Hirschmann
  • Process for preparing somatostatin analog
    Patent number: 4130554
    Abstract: Somatostatin analog, hereinafter designated des(Ala.sup.1 -Gly.sup.2)desaminocys.sup.3 -somatostatin, having the structure: ##STR1## is prepared by controlled stepwise procedures starting with individual amino acid components. This peptide has the property of lowering blood glucose, inhibiting gastric secretion and inhibiting growth hormone release in humans and animals.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: December 19, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Frederick W. Holly, William J. Paleveda, Robert G. Strachan, Daniel F. Veber
  • Cathepsin in D inhibitors
    Patent number: 3971736
    Abstract: Hexa- and heptapeptides of formula W-[X-Pro-Phe-Phe-Y-Z].sub.n H prepared by standard synthetic peptide techniques are anti-inflammatory, anti-rheumatoid arthritic and anti-ulcer agents.
    Type: Grant
    Filed: January 21, 1975
    Date of Patent: July 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Frederick W. Holly, Tsau-Yen Lin, Tsung-Ying Shen, Ralph F. Hirschmann
  • Analogs of thyrotropin-releasing hormone
    Patent number: 3959248
    Abstract: Novel tripeptides are disclosed. These tripeptides have anti-depressant activity and thyrotropin releasing hormone activity. Processes for preparing these tripeptides are also disclosed.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: May 25, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Frederick W. Holly, Ruth F. Nutt, Sandor L. Varga