Patents by Inventor Friedrich E. KRUSE

Friedrich E. KRUSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Application of laminin to corneal endothelial cell culture
    Patent number: 11624053
    Abstract: The present invention provides a method of culturing corneal endothelial cells. More specifically, the present invention provides a composition for culturing or growing corneal endothelial cells, comprising at least one agent consisting of laminins and fragments thereof which express in corneal endothelial cells. Specifically, the present invention can comprise laminin 511 (alpha5 beta1 gamma1) and laminin 512 (alpha5 beta2 gamma 1). The present invention further provides a culture container for corneal endothelial cells, which is coated with the composition of the present invention. Furthermore, the present invention provides a method for culturing corneal endothelial cells comprising the step of using the composition or the container of the present invention to culture the corneal endothelial cells.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: April 11, 2023
    Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, ActualEyes Inc., CorneaGen, Inc.
    Inventors: Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita, Friedrich E. Kruse, Ursula Schloetzer-Schrehardt
  • EXTRACELLULAR MATRIX MODULATING AGENT
    Publication number: 20220133714
    Abstract: The present invention provide an agent for modulating expression of extracellular matrix by corneal endothelial cells. The present invention pertains to an agent for modulating expression of extracellular matrix by corneal endothelial cells containing, 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof.
    Type: Application
    Filed: February 27, 2020
    Publication date: May 5, 2022
    Applicants: KOWA COMPANY, LTD.
    Inventors: Friedrich E. KRUSE, Ursula SCHLOTZER-SCHREHARDT
  • APPLICATION OF LAMININ TO CORNEAL ENDOTHELIAL CELL CULTURE
    Publication number: 20170002318
    Abstract: The present invention provides a method of culturing corneal endothelial cells. More specifically, the present invention provides a composition for culturing or growing corneal endothelial cells, comprising at least one agent consisting of laminins and fragments thereof which express in corneal endothelial cells. Specifically, the present invention can comprise laminin 511 (alpha5 beta1 gamma1) and laminin 512 (alpha5 beta2 gamma 1). The present invention further provides a culture container for corneal endothelial cells, which is coated with the composition of the present invention. Furthermore, the present invention provides a method for culturing corneal endothelial cells comprising the step of using the composition or the container of the present invention to culture the corneal endothelial cells.
    Type: Application
    Filed: November 26, 2014
    Publication date: January 5, 2017
    Applicants: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, THE DOSHISHA, SENJU PHARMACEUTICAL CO., LTD.
    Inventors: Noriko KOIZUMI, Naoki OKUMURA, Shigeru KINOSHITA, Friedrich E. KRUSE, Ursula SCHLOETZER-SCHREHARDT