Abstract: An in vitro culture system of human embryonic stem (hES) derived cells is used as a synthetic lethality screening platform for cells undergoing alternative lengthening of telomeres (ALT).

Abstract: The invention relates to new, cross-linkable compounds containing (A1) linear organopolysiloxanes with aliphatically unsaturated hydrocarbon radicals, said organopolysiloxanes being of general formula (I) R1aR3-aSiO(R2SiO)c[R2Si—Y—SiR2O(R2SiO)c]dSiR3-bR1b, wherein R can be the same or different, and represents a monovalent, optionally halogenated hydrocarbon radical which is free of terminal aliphatic carbon—carbon multiple bonds, R1 represents a monovalent aliphatically unsaturated hydrocarbon radical, Y represents a bivalent organic radical which is free of terminal aliphatic carbon—carbon multiple bonds, a is 0 or 1, b is 0 or 1, and the sum of a+b per molecule is 1 or 2, c is a whole number to the value of 1 to 1000, d is 0 or a whole number to the value of 1 to 10, and optionally, (A2) MQ silicone resins which are soluble in (A1), on the condition that if MQ silicone resins (A2) are not used, the sum of a+b in the formula (I) is 1.3 to 1.

Abstract: The invention relates to organopolysiloxanes which have aliphatically unsaturated radicals, are soluble to at least 80 wt % in organic solvents selected from xylene and toluol at a temperature of 25.degree. C. and a pressure of from 900 to 1100 hPa and contain at least one unit of the following formula (I) R.sup.1.sub.a R.sub.2-a SiO.sub.2/2, at least one unit of the following formula (II) R.sup.1.sub.b R.sub.3-b SiO.sub.1/2, at least one unit of the following formula (III) O.sub.1/2 R.sub.2 SiO.sub.x YRSiO.sub.2/2, and optionally at least one unit of the following formula (IV) O.sub.1/2 R.sub.2 SiO.sub.x YR.sub.2 SiO.sub.1/2, in which:R can be identical or different and is a monovalent, substituted or unsubstituted, SiC-bonded, aliphatically saturated hydrocarbon radical.R.sup.1 can be identical or different and is a monovalent, SiC-bonded, substituted or unsubstituted, aliphatically unsaturated hydrocarbon radical,a is 0, 1 or 2,b is 0, 1, 2 or 3,x is 0 or 1 andy is a radical --(CR.sup.3.sub.2).sub.n CHR.

Abstract: The present invention relates to organopolysiloxane resin solutions which contain 1-alkenes and are free from aromatic hydrocarbons, processes for their preparation and their use in organopolysiloxane compositions from which it is possible to produce coatings which repel tacky substances.

Abstract: The present invention relates to siloxane copolymers containing alkenyl groups and a process for their preparation. The siloxane copolymers of the present invention can be used in cross-linkable compositions for the production of coatings which repel tacky substances, an example of which would include coatings for release papers or films.

Abstract: Crosslinkable compositions containing(1) An organopolysiloxane having alkenyloxy functional groups and containing Si-bonded radicals Y of the formula--(CH.sub.2).sub.2 --R.sup.1 --(A--R.sup.2).sub.z --O--R.sup.3 --CH.dbd.CH.sub.2,in whichA represents --O--, --S--or ##STR1## group, R.sup.1 represents a straight-chain or branched alkylene radical having from 1 to 7 carbon atoms per radical of a cycloalkylene radical having from 5 to 7 carbon atoms per radical,R.sup.2 represents a straight-chain or branched alkylene radical having from 2 to 4 carbon atoms per radical, which can be substituted by a hydroxyl group, methoxy group, ethoxy group or trimethylsiloxy group,R.sup.3 represents a straight-chain or branched alkylene radical having from 1 to 7 carbon atoms per radical, and z is 0, 1 or 2,(2) an organopolysiloxane containing Si-bonded hydrogen atoms, and(3) a catalyst which promotes the addition of Si-bonded hydrogen to an aliphatic double bond.

Abstract: Compositions which may be crosslinked to form adhesive-repellent coatings having increased separation values, comprising organopolysiloxanes in which at least 95 mol percent of the siloxane units have the formulaHR.sup.1 C.dbd.CR.sup.2 COOR.sup.3 SiR.sub.2 O.sub.1/2,where R is a monovalent hydrocarbon radical or a halogenated monovalent hydrocarbon radical, R.sup.1 is hydrogen or a halogenated phenyl radical, R.sup.2 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms, R.sup.3 is a divalent hydrocarbon radical or a halogenated divalent hydrocarbon radical, in which the organopolysiloxanes also contain siloxane units of the formulasHSR.sup.4 SiRO and R.sub.2.sup.5 SiOin which R is the same as above, R.sup.4 is a divalent hydrocarbon radical, R.sup.5 is the same as R or a hydrocarbon radical substituted with the HR.sup.1 C.dbd.CR.sup.2 COO group, where R.sup.1 and R.sup.

Abstract: Organopolysiloxanes having a viscosity of at least 100 mPa.s at 25.degree. C. and having both SiC-bonded acryloxyalkyl groups and Si-bonded hydrogen atoms in the same molecule are described herein. These are preferably prepared by adding an allyl alcohol to diorganopolysiloxanes containing an Si-bonded hydrogen atom in each of their terminal units, then esterifying the hydroxyl groups of the resultant reaction product with acrylic acid and subsequently equilibrating the resultant diorganopolysiloxanes containing an SiC-bonded acryloxypropyl group in each of their terminal units, with organo(poly)siloxanes containing an Si-bonded hydroxyl group in each of their terminal units, in which the organo(poly)siloxanes contain methylhydrogensiloxane units and optionally diorganosiloxane units of the formulaR.sub.2 SiOas well as other organo(poly)siloxanes.

Abstract: Organopolysiloxanes which are crosslinked by high energy radiation consisting essentially of siloxane units of the formulas:(a) HR.sup.1 C.dbd.CR.sup.2 COOR.sup.3 SiR.sub.2 O.sub.1/2,(b) HSR.sup.4 SiRO and(c) R.sub.2.sup.5 SiOwhere R is a monovalent hydrocarbon radical or a halogenated monovalent hydrocarbon radical, R.sup.1 is hydrogen or a phenyl radical or a halogenated phenyl radical, R.sup.2 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms per radical and R.sup.3 is a hydrocarbon radical or a halogenated hydrocarbon radical, R.sup.4 is a divalent hydrocarbon radical, R.sup.5 is the same as R or a hydrocarbon radical substituted with the HR.sup.1 C.dbd.CR.sup.2 COO group, where R.sup.1 and R.sup.2 are the same as above, in which two siloxane units of the formulaHR.sup.1 C.dbd.CR.sup.2 COOR.sup.3 SiR.sub.2 O.sub.1/2are present per molecule. These organopolysiloxanes are prepared by equilibrating the corresponding siloxanes in accordance with the conventional methods known in the art.

Abstract: Organopolysiloxanes having a viscosity of at least 100 mPa.s at 25.degree. C. and having both SiC-bonded acryloxyalkyl groups and Si-bonded hydrogen atoms in the same molecule are described herein. These are preferably prepared by adding an allyl alcohol to diorganopolysiloxanes containing an Si-bonded hydrogen atom in each of their terminal units, then esterifying the hydroxyl groups of the resultant reaction product with acrylic acid and subsequently equilibrating the resultant diorganopolysiloxanes containing an SiC-bonded acryloxypropyl group in each of their terminal units, with organo(poly)siloxanes containing an Si-bonded hydroxyl group in each of their terminal units, in which the organo(poly)siloxanes contain methylhydrogensiloxane units and optionally diorganosiloxane units of the formulaR.sub.2 SiOas well as other organo(poly)siloxanes.

Abstract: Coatings which have a predetermined degree of adhesive-repellency are prepared by applying to surfaces which are to be rendered adhesive-repellent an organopolysiloxane having Si-bonded hydrogen and an aliphatic multiple bond in the same molecule and a catalyst which promotes the addition of Si-bonded hydrogen to an aliphatic multiple bond, and thereafter crosslinking the organopolysiloxane by the addition of Si-bonded hydrogen to an aliphatic multiple bond. The organopolysiloxane having both an aliphatic multiple bond and Si-bonded hydrogen in the same molecule, has a viscosity of at least 300 mPa.s at 25.degree. C. The adhesive-repellency of the coated substrate is at least partially dependent on the ratio of Si-bonded hydrogen to the aliphatic multiple bond, i.e., the higher the ratio of Si-bonded hydrogen to the aliphatic multiple bond, the lower the adhesive-repellency.

Abstract: Coating compositions which impart adhesive repellent or non-adherent properties to substrates coated therewith comprising (1) vinyl endblocked diorganopolysiloxanes having an average viscosity in excess of 10.sup.6 cP at 25.degree. C. in which from 3 to 30 mole percent of the nonterminal siloxane units are diphenylsiloxane units and at least 50 mole percent of the remaining organic radicals on the siloxane units are methyl radicals, (2) organopolysiloxanes having at least 3 Si-bonded hydrogen atoms per molecule, (3) catalysts which promote the addition of Si-bonded hydrogen atoms to the vinyl groups and (4) an inert organic solvent. These coating compositions may be applied to cellulosic materials and other substrates to impart varying degrees of adhesive repellency thereto.

Abstract: A process for preparing adhesive repellent coatings which comprises applying to the surface to be rendered adhesive repellent a mixture containing (1) a diorganopolysiloxane having an Si-bonded vinyl group in each of the terminal units, but is otherwise free of aliphatic unsaturation, (2) an organopolysiloxane having at least 3 Si-bonded hydrogen atoms per molecule, (3) a vinylsiloxane platinum complex and (4) an organic or organosilicon compound which retards or delays the addition of Si-bonded hydrogen to aliphatic multiple bonds, said compound has a boiling point of at least 25.degree. C. at 760 mm Hg (absolute) and at least one aliphatic triple bond, and thereafter crosslinking the diorganopolysiloxane (1).

Abstract: Coating compositions which impart adhesive repellent or non-adherent properties to substrates coated therewith comprising (1) vinyl endblocked diorganopolysiloxanes having an average viscosity in excess of 10.sup.6 cP at 25.degree. C. in which from 3 to 39 mole percent of the nonterminal siloxane units are diphenylsiloxane units and at least 50 mole percent of the remaining organic radicals on the siloxane units are methyl radicals, (2) organopolysiloxanes having at least 3 Si-bonded hydrogen atoms per molecule, (3) catalysts which promote the addition of Si-bonded hydrogen atoms to the vinyl groups and (4) an inert organic solvent. These coating compositions may be applied to cellulosic materials and other substrates to impart varying degrees of adhesive repellency thereto.