Abstract: Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an emollient such as dimethicone, glycerol or isostearyl isostearate are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as dry skin or atopic or contact dermatitis.

Abstract: Snyergistic combination of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a ceramide such as ceramide 3, LPC-9S or linoleic acid are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as atopic or contact dermatitis or dry skin, asteatotic eczema or xerosis.

Abstract: Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a calciferol or tacalcitol are provided, which are useful in particular in the treatment of dermatological diseases such as atopic dermatitis, acen and psoriasis or of inflammatory bowel disease (IBD).

Abstract: Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.

Abstract: The present invention relates to sustained release pharmaceutical composition for oral administration comprising terbinafine.

Abstract: A variety of applications do not require a high data throughput. The standardization of the interface in the field of smart cards fixes the processing width at 1 bit. Therefore, it is effective to use a programmable structure which operates with a data width of one bit. A data processing arrangement in the form of a 1-chip implementation with a processing width of 1 bit can be used in chip cards for simple control and automation functions while utilizing serial protocols. This structure features uncomplicated circuitry, a small chip surface area, a wide field of application and a low power consumption.

Abstract: Brake lock in a fluid operated braking system is automatically suppressed by a brake diminishing cylinder and piston unit between the master cylinder and at least one wheel brake cylinder. Spring pressure upon the brake diminishing piston is normally over-balanced by a backstop pressure which is monitored by a wheel sensor. When a brake lock is imminent the backstop pressure drops and causes shifting of the brake diminishing piston from a first position in which it connects the main cylinder with the wheel cylinder into a second position in which it disconnects the main cylinder from the wheel cylinder and lowers the fluid pressure in the latter. Timely restoration of the backstop fluid pressure is insured by electrical contact elements disposed on the brake diminishing piston and engageable with complementary electrical contacts on the brake diminishing cylinder and functional to cause increased backstop pressure to be applied.