Patents by Inventor Fritz H. Bach

Fritz H. Bach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING INFLAMMATION BY ADMINISTRATION OF HEME OXYGENASE-1 AND PRODUCTS OF HEME DEGRADATION
    Publication number: 20120195976
    Abstract: The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products.
    Type: Application
    Filed: December 9, 2011
    Publication date: August 2, 2012
    Inventors: Fritz H. Bach, Pascal O. Berberat, Simon C. Robson
  • Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
    Patent number: 8097585
    Abstract: The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: January 17, 2012
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Fritz H. Bach, Pascal O. Berberat, Simon C. Robson
  • Methods of treating vascular disease
    Patent number: 7691416
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: April 6, 2010
    Assignees: Beth Israel Deaconess Medical Center, Inc., University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Leo E. Otterbein, Augustine M. Choi, Fritz H. Bach, Brian Zuckerbraun
  • PHARMACEUTICAL USE OF NITRIC OXIDE, HEME OXYGENASE-1 AND PRODUCTS OF HEME DEGRADATION
    Publication number: 20080171021
    Abstract: The present invention relates to the treatment of disorders using nitric oxide (NO), heme oxygenase-1 (HO-1) and heme degradation products such as carbon monoxide (CO), biliverdin, bilirubin and iron.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 17, 2008
    Applicants: Beth Israel Deaconess Medical Center, Inc., University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Fritz H. Bach, Leo E. Otterbein
  • METHODS OF TREATING VASCULAR DISEASE
    Publication number: 20080167609
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: March 18, 2008
    Publication date: July 10, 2008
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
  • Methods of treating vascular disease
    Patent number: 7364757
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: April 29, 2008
    Assignees: University of Pittsburgh of the Commonwealth System of Higher Education, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
  • Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
    Patent number: 7238469
    Abstract: The present invention features methods for transplanting organs, tissues and individual cells. Also featured are methods for maintaining cells in vitro and for enhancing survival and/or function of cells following transplantation. The methods include the administration of carbon monoxide in an amount sufficient to enhance cell survival and/or function.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 3, 2007
    Assignees: Beth Israel Deaconess Medical Center, Inc., Yale University
    Inventors: Fritz H. Bach, Leo E. Otterbein, Miguel P. Soares, Jeanne Gose
  • ATP diphosphohydrolase (CD39) gene therapy for inflammatory or thrombotic conditions and transplantation and means therefor
    Publication number: 20040148645
    Abstract: A method to render endothelial cells capable of inhibiting platelet and leukocyte-mediated injury and inflammation is described, comprising genetically modifying the cells by inserting DNA encoding ecto-ATP diphosphohydrolase or an oxidation-resistant analog thereof, and expressing a protein having functional ecto-ATP diphosphohydrolase activity, such as the human CD39 protein, by said cells under cellular activating conditions. The method, which can be carried out in vivo, ex vivo or in vitro, has use in allogeneic or xenogeneic transplantation as well as to treat systemic or local inflammatory conditions characterized by platelet aggregation leading to thrombus formation.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 29, 2004
    Inventors: Fritz H. Bach, Simon Robson, Adrien R. Beaudoin, Jean Sevigny
  • Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
    Publication number: 20040131703
    Abstract: The present invention relates to the treatment of disorders using nitric oxide (NO), heme oxygenase-1 (HO-1) and heme degradation products such as carbon monoxide (CO), biliverdin, bilirubin and iron.
    Type: Application
    Filed: June 20, 2003
    Publication date: July 8, 2004
    Inventors: Fritz H. Bach, Leo E. Otterbein
  • Methods of treating vascular disease
    Publication number: 20030219496
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: February 13, 2003
    Publication date: November 27, 2003
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
  • ATP-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology
    Publication number: 20030040094
    Abstract: The present invention relates to two ATP diphosphohydrolases (ATPDase enzymes) isolated from bovine aorta and pig pancreas, which enzymes have a molecular weight for their catalytic unit of about 78 and 54 Kilodaltons, respectively. A first process for obtaining a highly purified ATPDase is also an object of the present invention. This process has been successfully applied to the purification of both the pancreatic and the aorta enzymes and is deemed to work in the purification of any ATPDase. For both sources of enzymes, the process allows the specific activity of the enzyme to be increased by at least 10,000 fold when compared to the activity retrieved in the crude cell homogenates. The novel process involves an ion exchange chromatography step, a separation on an affinity column, followed by an electrophoresis under non-denaturing conditions.
    Type: Application
    Filed: February 12, 2001
    Publication date: February 27, 2003
    Inventors: Adrien R. Beaudoin, Jean Sevigny, Fritz H. Bach, Simon C. Robson
  • Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
    Publication number: 20030039638
    Abstract: The present invention features methods for transplanting organs, tissues and individual cells. Also featured are methods for maintaining cells in vitro and for enhancing survival and/or function of cells following transplantation. The methods include the administration of carbon monoxide in an amount sufficient to enhance cell survival and/or function.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 27, 2003
    Inventors: Fritz H. Bach, Leo E. Otterbein, Miguel P. Soares, Edda M. Tobiasch, Jeanne Gose
  • DNA and amino acid sequence specific for natural killer cells
    Patent number: 6262244
    Abstract: Proteins expressed in NK and some T cells and being transmembrane molecules with Type II membrane protein structure, the extracellular part of the receptor being characterized by a C-type animal lectin domain, DNA sequences encoding such proteins and antibodies against the extracellular part of the transmembrane protein which can activate NK and T cells.
    Type: Grant
    Filed: October 13, 1995
    Date of Patent: July 17, 2001
    Assignees: Regents of the University of Minnesota, Novartis AG
    Inventors: Jeffrey P. Houchins, Toshio Yabe, Cynthia M. McSherry, Fritz H. Bach, Erhard Hofer
  • Method of enhancing the immunotherapeutic activity of immune cells by depletion of CD8.sup.+ T cells
    Patent number: 5641677
    Abstract: The present invention provides a method for enhancing the immunotherapeutic activity, e.g., cytotoxicity, of immune cells by depleting immune cells of a cell subset that down-regulates the immune response, such as either CD4.sup.+ or CD8.sup.+ lymphocytes. The remaining depleted immune cells are then cultured in the presence of interleukin-2 (IL-2) and an antibody to a lymphocyte surface receptor, preferably an anti-CD3 monoclonal antibody (MoAb). The present invention also provides a method of enhancing the immunotherapeutic activity, e.g., cytotoxicity, of immune cells by culturing immune cells in the presence of IL-2 and an antibody to a lymphocyte surface receptor, preferably an anti-CD3 MoAb; separating a cell subset capable of developing immunotherapeutic activity, e.g., cytotoxicity, from the cultured immune cells, e.g., either CD4.sup.+ or CD8.sup.+ lymphocytes; and then subculturing the separated lymphocytes in the presence of IL-2.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: June 24, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Augusto Carlos Ochoa, Robin Lee Geller, Fritz H. Bach
  • Method of culturing lymphocytes and method of treatment using such lymphocytes
    Patent number: 5443983
    Abstract: In accordance with the present invention, a method of culturing lymphocytes is disclosed in which the lymphocytes are cultured in the presence of interleukin-2 (IL-2) and an antibody to a lymphocyte surface receptor, preferably an antibody to a lymphocyte T3 surface receptor. Preferably, the antibody is monoclonal. Cells cultured with anti-CD3 maintain their LAK activity as they increase in number. The cells can also be cultured in the presence of an additional lymphokine to obtain additional LAK activity.Methods of medical treatment are also disclosed in which cells cultured in accordance with the culturing methods of the present invention are introduced into the individual to be treated.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: August 22, 1995
    Assignee: Regents of the University of Minnesota
    Inventors: Augusto C. Ochoa, Fritz H. Bach, Barbara Alter, Paul Sondel
  • Method for typing human leukocyte antigens
    Patent number: 4265873
    Abstract: A cellular method for typing lymphocyte defined human leukocyte antigens by utilizing human blood leukocytes which have been sensitized to proliferatively respond to the secondary stimulus of the leukocyte antigens to which they have been sensitized. The sensitization is accomplished by incubating, in vitro, in a mixed leukocyte culture, the leukocytes to be sensitized with leukocytes differing by only a single major histocompatibility complex haplotype or a single HLA-D antigenic determinant.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: May 5, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael J. Sheehy, Paul M. Sondel, Fritz H. Bach, Marilyn L. Bach, Rudolf Wank
  • Method for preparing a reagent for PLT and method of use
    Patent number: 4124701
    Abstract: A method for preparing a reagent for primed LD typing which comprises sensitizing purified human blood leukocytes to a secondary proliferative response by incubating them, in vitro, in mixed leukocyte culture, with lymphoblastoid cell lines from homozygous typing cells, or from other cells of specified genetic type homozygous for HLA-D, or other continuous line.
    Type: Grant
    Filed: July 11, 1977
    Date of Patent: November 7, 1978
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marilyn L. Bach, Fritz H. Bach