Patents by Inventor Fumio Ishii
Fumio Ishii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6958353Abstract: The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.Type: GrantFiled: June 8, 2001Date of Patent: October 25, 2005Assignee: Hisamitsu Medical Co., Ltd.Inventors: Fujiko Konno, Yoshihiro Nagao, Kazuo Isomae, Mari Ohtsuka, Yoshiyuki Takahashi, Fumio Ishii, Hiroyuki Hirota, Sunao Takeda, Noriyuki Kawamoto, Haruyoshi Honda, Susumu Sato
-
Publication number: 20030207896Abstract: The invention is directed to an imidazole derivative represented by formula (1): 1Type: ApplicationFiled: November 5, 2002Publication date: November 6, 2003Inventors: Fujiko Konno, Yoshihiro Nagao, Kazuo Isomae, Mari Ohtsuka, Yoshiyuki Takahashi, Fumio Ishii, Hiroyuki Hirota, Sunao Takeda, Noriyuki Kawamoto, Haruyoshi Honda, Susumu Sato
-
Patent number: 6242609Abstract: A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of a four equivalent coupler using a halogenating agent, wherein said halogenating agent is said ammonium trihalide.Type: GrantFiled: April 7, 1999Date of Patent: June 5, 2001Assignee: Konica CorporationInventor: Fumio Ishii
-
Patent number: 6124347Abstract: Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.Type: GrantFiled: September 29, 1998Date of Patent: September 26, 2000Assignee: SSP Co., Ltd.Inventors: Fumio Ishii, Haruyoshi Honda, Fujiko Konno, Tomomi Okada, Terumitsu Kaihoh, Yoshihiro Nagao, Susumu Sato, Hideaki Matsuda
-
Patent number: 6010809Abstract: A silver halide light-sensitive color photographic material is disclosed. The material comprises thermotropic low molecular crystal. The material is improved in light fastness of a dye image and dye-forming efficiency.Type: GrantFiled: June 10, 1998Date of Patent: January 4, 2000Assignee: Konica CorporationInventors: Fumio Ishii, Shinichi Daiba, Tomohiro Oshiyama, Shigeto Hirabayashi, Yoshiko Iwai
-
Patent number: 5962509Abstract: Disclosed are dithiolylidene acetamide derivatives represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.Type: GrantFiled: October 13, 1998Date of Patent: October 5, 1999Assignee: SSP Co., Ltd.Inventors: Fumio Ishii, Kinichi Mogi, Hiromichi Eto, Susumu Sato, Hideaki Matsuda
-
Patent number: 5922767Abstract: Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently H, a halogen atom, or an alkyl or alkoxyl group, R.sup.3 is a phenyl or heterocyclic group which may be substituted, n is an integer of 1-6, and R.sup.4 is a phenyl group which may be substituted, or salts thereof, and medicines comprising such a derivative as an active ingredient. The derivatives or salts thereof strongly inhibit only ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.Type: GrantFiled: October 7, 1997Date of Patent: July 13, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kanamaru, Hiroyuki Hirota, Akihiro Shibata, Teruo Komoto, Hiroyuki Naito, Koichi Tachibana, Mari Ohtsuka, Fumio Ishii, Susumu Sato
-
Patent number: 5866609Abstract: Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.Type: GrantFiled: July 24, 1997Date of Patent: February 2, 1999Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kanamaru, Hiroyuki Hirota, Akihiro Shibata, Teruo Komoto, Hiroyuki Naito, Koichi Tachibana, Mari Ohtsuka, Fumio Ishii, Susumu Sato
-
Patent number: 5376514Abstract: A silver halide photosensitive photographic material comprising a support and provided thereon, photographic component layers including at least one silver halide emulsion layer is disclosed, wherein the photosensitive silver halide grains contained in all the silver halide emulsion layers have an average silver iodide content ranging from 0 to 3 mol % and contain at least silver bromide; and at least one of the silver halide emulsion layers contain a diequivalent phenolic cyan dye-forming coupler having a ureido group in a 2-position of a phenolic nucleus.Type: GrantFiled: March 4, 1994Date of Patent: December 27, 1994Assignee: Konica CorporationInventors: Satoru Shinba, Toshihiko Kimura, Fumio Ishii
-
Patent number: 5158856Abstract: A silver halide photographic light-sensitive material having a support and provided thereon, at least one silver halide emulsion layer containing Compound [I] or Compound [II] represented by Formula [I] or [II] is disclosed; ##STR1##Type: GrantFiled: February 18, 1992Date of Patent: October 27, 1992Assignee: Konica CorporationInventors: Yasushi Usagawa, Fumio Ishii
-
Patent number: 5100773Abstract: There is disclosed the silver halide light-sensitive color photographic material having an excellent dispersing stability in a silver halide emulsion, a satisfactory color formability and a sufficient maximum color density, and capable of providing a high reactivity or a high quality image, wherein the photographic material contains at least one selected from the couplers represented by Formulas I and II: ##STR1##Type: GrantFiled: November 27, 1989Date of Patent: March 31, 1992Assignee: Konica CorporationInventors: Atsushi Tomotake, Shuji Kida, Mayumi Tomotake, Fumio Ishii
-
Patent number: 4994361Abstract: A silver halide color photographic light-sensitive material is disclosed in which a novel yellow coupler represented by the following Formula I is contained. ##STR1## wherein R.sub.1 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; R.sub.2 and R.sub.3 are each a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group; X is a hydrogen atom, a halogen atom, an alkoxy group or an alkylamino group; Y, B.sub.1 and B.sub.2 are each a substituent; and m and n are each an integer of zero to 3.Type: GrantFiled: November 27, 1989Date of Patent: February 19, 1991Assignee: Konica CorporationInventors: Atsushi Tomotake, Shuji Kida, Mayumi Tomotake, Fumio Ishii
-
Patent number: 4977063Abstract: A silver halide photographic light-sensitive material is disclosed, which is inhibited in formation of pepper spot in a halftone image and capable of making extremely high contrast image thereon. The light-sensitive material contains a compound represented by the following formula: ##STR1## wherein A.sub.1 and A.sub.2 are each an arylene group or a divalent heterocyclic group; L is a linking group;z is a formyl group, an acyl group, a sulfonyl group, a carbamoyl group, a sulfamoyl group, an alkoxycarbonyl group, a thioacyl group or a ##STR2## group; X is --NR.sub.6 R.sub.7 or --OR.sub.8, in which R.sub.6 and R.sub.7 are each a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a heterocyclic group, a hydroxy group, an alkoxy group, an alkenylkoxy group, an alkynyloxy group, an aryloxy group, or a heterocyclic oxy group, and R.sub.8 is a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group; n is 1 or 2; m is 0 or 1; R.sub.1 and R.sub.Type: GrantFiled: March 2, 1989Date of Patent: December 11, 1990Assignee: Konica CorporationInventors: Yasushi Usagawa, Fumio Ishii
-
Silver halide color photographic light-sensitive material containing pyrazoloazole type cyan coupler
Patent number: 4873183Abstract: A light-sensitive silver halide color photographic material comprising a support and, provided thereon, a red light-sensitive silver halide emulsion layer containing a novel pyrazoloazole type cyan dye-forming coupler having at least one electron attractive group at a substitutable position except the active site of the coupler for coupling reaction.Type: GrantFiled: December 29, 1988Date of Patent: October 10, 1989Assignee: Konica CorporationInventors: Kimie Tachibana, Yutaka Kaneko, Fumio Ishii -
Patent number: 4849512Abstract: Derivatives of 3-acylamino-3-deoxyallose represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen atoms, or R.sup.1 and R.sup.2, and R.sup.3 and R.sup.4 may be in combination an isopropylidene group, R.sup.5 represents a hydrogen atom or alkyl group, and R.sup.6 represents a hydrogen atom or acyl group, are disclosed. One of the typical compound 3-deoxy-3-(3-tetradecanoyloxytetradecanoylamino)-1,2:5,6-di-O-isopropylide ne- .alpha.-D-allofuranose is prepared by reacting 3-tetradecanoyloxytetradecanoic acid and 3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-.alpha.-D-allofuranose in the presence of N,N'-dicyclohexylcarbodiimide, as a dehydrating agent. The compound has an excellent carcinostatic activity.Type: GrantFiled: April 1, 1988Date of Patent: July 18, 1989Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Mari Otsuka, Kazuhiko Irinoda, Seiji Ishizeki, Fumio Ishii, Kenichi Kukita, Hideaki Matsuda, Tatsuhiko Katori
-
Patent number: 4840882Abstract: In a heat-developable color light-sensitive material comprising a support having thereon at least two light-sensitive layers each comprising a light-sensitive silver halide, organic silver salt, dye-donating material capable of releasing or forming a diffusible dye by heat development, reducing agent, and hydrophilic binder, said at least two light-sensitive layers differing from each other in the color sensitivity of said light-sensitive silver halide and in the hue of said diffusible dye, said heat-developable color light-sensitive material, wherein at least one of said light-sensitive layer(s) containing said dye-donating materials are hardened with a hardening agent for said hydrophilic binder. The foregoing heat-developable color light-sensitive material prevents diffusion of the dye-donating material and reduces or prevents the color-crossover phenomenon. Transferability of the dye is also improved as is scratch resistance of the photographic component layers.Type: GrantFiled: August 31, 1988Date of Patent: June 20, 1989Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Masaru Iwagaki, Takashi Sasaki, Tawara Kumamura, Fumio Ishii, Kunihiro Koshizuka
-
Patent number: 4770989Abstract: A heat-developable color photosensitive element having a support bearing thereon at least one photographic component layer containing a photosensitive silver halide, an organic silver salt, a reducing agent, a dye donor substance and a binder. The photosensitive element is characterized by the photographic component layer which contains a thermal solvent and a binder which contains both a gelatin and a vinyl pyrrolidone polymer.Type: GrantFiled: May 4, 1987Date of Patent: September 13, 1988Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Tawara Komamura, Masaru Iwagaki, Takashi Sasaki, Fumio Ishii, Kunihiro Koshizuka
-
Patent number: 4728260Abstract: An impeller driven by a reversible motor is set in a housing and a functional path capable of sending out liquid by pump action is formed between the inner wall of the housing and the impeller. On the both-end side of the functional path are provided two adjacent valve chambers divided by a partition, and within this partition is provided a liuqid introducing path leading to the valve chambers via inlets. On the wall of the valve chamber facing the inlet is opened an outlet, and a valve body which opens and closes the inlets and outlets is set. The liquid introducing path, one valve chamber, the functional path, and the other valve chamber are arranged in series, so that, while one valve chamber is positive in pressure, the other chamber does not fail to be negative in pressure. Thus, liquid is sent out exactly to the outlet on the positive pressure side, without being erroneously set to the other outlet on the negative pressure side.Type: GrantFiled: April 21, 1987Date of Patent: March 1, 1988Assignee: Maruko Keihouki Kabushiki KaishaInventor: Fumio Ishii
-
Patent number: 4695533Abstract: This invention relates to a silver halide photographic light-sensitive material in which at least one of the silver halide emulsion layers thereof contains an 1H-pyrazolo[3,2-C]-s-triazole magenta coupler substituted in the third position by a group represented by the following Formula [I];--R.sub.1 --SO.sub.2 --R.sub.2 Formula [I]wherein R.sub.1 represents an alkylene group having not less than 3 carbon atoms in the straight-chained portion thereof, which is capable of linking a --SO.sub.2 --R.sub.2 to the carbon atom in the third position of the nucleus of the 1H-pyrazolo[3,2-C]-s-triazole; and R.sub.2 represents an aryl group.The silver halide photographic light-sensitive materials of the invention are excellent in light-resistance of magenta dye images and also spectral absorption characteristics.Type: GrantFiled: May 28, 1986Date of Patent: September 22, 1987Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Noritaka Nakayama, Satoshi Kawakatsu, Katsunori Katoh, Toshijumi Iijima, Kenji Kumashiro, Hiroshi Kashiwagi, Koichi Hatta, Takashi Uchida, Hajime Wada, Fumio Ishii, Satoshi Matsunaga, Yasuko Matsubara, Kaoru Shinozaki
-
Patent number: 4692529Abstract: A method for synthesizing a magenta coupler. The synthesis is carried out through (1) 3-pyrazoline-5-ones which are obtained by substituting a blocking group at the nitrogen atom in the second position thereof; or (2) pyrazoles which are obtained by substituting a blocking group at the hydroxyl group bonded in the fifth position thereof. The magenta coupler obtained has the formula ##STR1## wherein R.sub.1 is an aryl or heterocyclic group, R.sub.2 is an acylamide, anilino or ureido group, and R3 is an alkyl, aryl, or heterocyclic group.Type: GrantFiled: November 10, 1983Date of Patent: September 8, 1987Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Kasaku Masuda, Ryosuke Sato, Fumio Ishii, Kazuhiko Kimura, Hidetaka Ninomiya