Abstract: An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. [Method for Achieving the Object] The microneedle array is produced by forming microneedles using proteoglycan as a base material.

Abstract: Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.

Abstract: This invention is to provide a transdermal administration type pharmaceutical preparation which has better transdermal absorptivity, safety and practical application for treatment of bone calcium metabolic diseases, such as high calcium in blood which resulted from osteoporosis, osteitis deformans and malignant tumors.

Abstract: Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.

Abstract: This invention is concerned with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation.

Abstract: This invention is to provide a transdermal permeation preparation which includes a concentrated transdermal active ingredient laminate and exhibits high transdermal permeation effect; and a method for producing the preparation A transdermal permeation preparation which comprises a base material which is a hydrophilic macromolecule which can swell after absorbing the water and/or water-containing alcohol and comprises a transdermal active ingredient which is in a molecular weight higher than 1000 Dalton and can dissolve or suspend in water and/or water-containing alcohol laminated on the surface of the base material; and a method for producing the transdermal permeation preparation wherein the transdermal active ingredient of a molecular weigh higher than 1000 Dalton is dissolved or suspended in water and/or water-containing alcohol to form an aqueous solution or suspension and the said aqueous solution or suspension is coated on the surface of base materials which are hydrophilic macromolecules which can swel

Abstract: This invention is to provide a diffusion testing device to facilitate determination of diffusivity of prolonged release of drugs from transdermal therapeutic preparation. The diffusion testing device is characterized by a receptor liquid reservoir; a diffusion testing cell having a receptor chamber functioning to be full of receptor liquid and within which a stirrer be placed, a receptor liquid supply unit, a thermostat bath to hold the diffusion testing cell, a stirring apparatus located beneath the thermostat bath to cause the rotation action of the stirrer set in the receptor chamber, a sampling unit permitting sampling and storage of receptor liquid dissolving permeated drugs. Said receptor liquid reservoir, said receptor chamber, said receptor liquid supply unit and said sampling unit are connected with each other via infusion tube.

Abstract: A composition for production of a crosslinkable pressure-sensitive adhesive for skin, obtained by dissolving in a solvent 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth)acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups.

Abstract: A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material, ingredients, and an active ingredient, wherein said adhesive base is a copolymer containing one or more (meth) alkyl acrylate monomers and one or more monomers copolymerizable with the (a) monomer selected from the group of unsaturated ethylenically unsaturated monomers, and said ingredients are diethylene glycol monocetyl ether, octanoic acid and/or oleic acid, lauric acid diethanolamide, polyvinylpyrollidone; and said active ingredient is fentanyl.

Abstract: Compounds of formula (I) (in which R1; R2, R3 and R4 are the same as or different from each other and each represents an oxo group, a hydroxy group, a mercapto group, a hydrogen atom, a halogen atom, an alkoxy group or an aryloxy group; and the dotted line indicates that there may be a single or double bond between one of the respective pairs of carbon atoms) and esters thereof can be administered by transdermal administration. They are particularly effective when applied as a patch, preferably with an adhesive comprising a copolymer of from 40 to 60% by weight of methoxyethyl acrylate, from 30 to 40% by weight of lauryl acrylate or lauryl methacrylate and from 10 to 25% by weight of a polar monomer.

Abstract: It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.

Abstract: Cross-linked block copolymers are disclosed which have drug retention properties, comprising hard and soft segments, with cross-linking between the soft segments. The block copolymers can be based upon (meth)acrylic monomers, and some possess adhesive properties.

Abstract: An adhesive material is suitable as a bioadhesive and comprises an adhesive polymer and a plasticizier thereof, wherein the adhesive is cross-linked, characterized in that the adhesive comprises ketone groups cross-linked by a polyamine cross-linking agent. Such adhesives have good cohesion and low dermal irritation.

Abstract: A grooved nut including a cylindrical shaft portion having a screw hole at the center, a head portion whose outer periphery is polygonal and which is provided at one end portion of the shaft portion, and a peripheral groove provided at a boundary part between the head portion and the shaft portion, in which the peripheral groove is formed by a plasticizing process.

Abstract: A grooved nut including a cylindrical shaft portion having a screw hole at the center, a head portion whose outer periphery is polygonal and which is provided at one end portion of the shaft portion, and a peripheral groove provided at a boundary part between the head portion and the shaft portion, in which the peripheral groove is formed by a plasticizing process.

Abstract: A filler for liquid chromatography, said filler consisting essentially of a hydrophilic ion-exchanger obtained by copolymerizing a mixture of (A) 5 to 90% by weight of a polymerizable monomer containing one polymerizable double bond and at least one carboxyl group per molecule and having a hydrophobic parameter of not more than 2.3, (B) 10 to 95% by weight of a crosslinkable polymerizable monomer containing at least two polymerizable double bonds per molecule and having a hydrophobic parameter of not more than 2.3, and (C) 0 to 85% by weight of a monomer being different from the monomer (A), containing one polymerizable double bond per molecule and having a hydrophobic parameter of not more than 2.3; and a method for separating a biological material such as proteins, enzymes and amino acids by liquid chromatography using the aforesaid filler.

Abstract: A liquid-chromatographic filler comprising a particulate synthetic polymer, such as glycerol di or tri (meth) acrylate wherein the filler exhibits a behavior such that in chromatography using polyethylene glycol as a sample and water as an eluent, the elution time of the sample increases with a rise in temperature. Separation of water-soluble substances by liquid chromatography can be achieved by using an aqueous medium as an eluent, and this filler.