Patents by Inventor Fuwen Xie
Fuwen Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240156166Abstract: An vaporizer includes an outer housing that is internally provided with: a liquid storage chamber; a liquid guide element, including a first portion extending in the direction perpendicular to the longitudinal direction of the outer housing; a heating element at least partially surrounding the liquid guide element, and configured to heat at least part of the liquid substrate in the liquid guide element to generate an aerosol; and a liquid buffer space, at least partly surrounding the liquid guide element and avoiding the heating element for storing the liquid substrate to adjust the efficiency of transferring the liquid substrate to the heating element. With the above vaporizer, the transferred liquid substrate is buffered through a liquid buffer space at least partially surrounding the second liquid guide element, so that the amount of the liquid substrate supplied to the heating element is balanced, thus reducing E-liquid being blown off.Type: ApplicationFiled: January 19, 2022Publication date: May 16, 2024Applicant: SHENZHEN FIRST UNION TECHNOLOGY CO.,LTD.Inventors: Baofeng XIE, Fuwen LIN, Zhongli XU, Yonghai LI
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Publication number: 20240148066Abstract: An vaporizer includes an outer housing; the outer housing is internally provided with: a liquid storage chamber having an opening; a first liquid guide element having a first surface close to the liquid storage chamber in a longitudinal direction of the outer housing, and a second surface away from the first surface; the first surface sucks the liquid substrate; and the first liquid guide element is made from an organic porous material and is configured to cover the opening to seal the liquid storage chamber, such that the liquid substrate in the liquid storage chamber is substantially removed through the first liquid guide element; a second liquid guide element, configured to at least partially contact with the second surface to suck the liquid substrate; and a heating element, configured to heat at least part of the liquid substrate in the second liquid guide element to generate an aerosol.Type: ApplicationFiled: January 19, 2022Publication date: May 9, 2024Applicant: SHENZHEN FIRST UNION TECHNOLOGY CO., LTD.Inventors: Baofeng XIE, Fuwen LIN, Zhongli XU, Yonghai LI
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Publication number: 20240090579Abstract: A vaporizer includes: an outer housing, where the outer housing is internally provided with: a liquid storage chamber; a support, constructed to at least partially define a vaporization chamber; a smoke output tube for outputting an aerosol, constructed to substantially extend in the longitudinal direction of the outer housing, where the smoke output tube has an air inlet end being in airflow communication with the vaporization chamber; and a capillary channel is defined between the air inlet end and the support, so as to transfer an aerosol condensate at the air inlet end out of the smoke output tube. For the foregoing vaporizer, the condensate at the air inlet end of the smoke output tube is transferred out of the smoke output tube through the capillary channel, so as to slow down or eliminate the phenomenon that the condensate is sucked.Type: ApplicationFiled: January 19, 2022Publication date: March 21, 2024Applicant: SHENZHEN FIRST UNION TECHNOLOGY CO., LTD.Inventors: Baofeng XIE, Fuwen LIN, Zhongli XU, Yonghai LI
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Publication number: 20240081403Abstract: An vaporizer includes an outer housing, where the outer housing is internally provided with: a liquid storage chamber; a first liquid guide element, having a first surface and a second surface opposite to each other, where the first surface sucks a liquid substrate in the liquid storage chamber; a second liquid guide element, arranged close to the second surface of the first liquid guide element, and configured to contact with the second surface to suck the liquid substrate; a heating element, configured to heat at least part of the liquid substrate in the second liquid guide element to generate an aerosol; and an air channel providing a flowing path for air to cross the first liquid guide element and enter the liquid storage chamber in the longitudinal direction of the outer housing.Type: ApplicationFiled: January 19, 2022Publication date: March 14, 2024Applicant: SHENZHEN FIRST UNION TECHNOLOGY CO.,LTD.Inventors: Baofeng XIE, Fuwen LIN, Zhongli XU, Yonghai LI
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1-oxo/acylation-14-acylated oridonin derivative, preparation method therefor and application thereof
Patent number: 9902736Abstract: The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylated-14-acylated oridonin derivative of a general formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and application thereof in preparation of antitumor drugs.Type: GrantFiled: January 21, 2013Date of Patent: February 27, 2018Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai -
Patent number: 9771343Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-alkyl- or 2-aromatic-substituted tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When Z=R, said derivative is 2-alkyl-substituted tanshinone I; when Z=Ar, said derivative is 2-aryl-substituted tanshinone I; when Z=Het, said derivative is 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I.Type: GrantFiled: November 30, 2012Date of Patent: September 26, 2017Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
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Patent number: 9676789Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: August 20, 2012Date of Patent: June 13, 2017Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
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Patent number: 9428519Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel homoharringtonine acylated derivatives of formula (I) and formula (II) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: August 20, 2012Date of Patent: August 30, 2016Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Patent number: 9353146Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel Polyphyllin I derivatives of formula (I) that is acylated at the 5?-position of arabinofuranosyl or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: June 13, 2013Date of Patent: May 31, 2016Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTDInventors: Rongzhen Xu, Frank Rong, Fuwen Xie
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Patent number: 9328083Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When X is nitrogen, formula I indicates 2-aminated methylene tanshinone I; when X is oxygen, formula I indicates 2-esterified methylene tanshinone I.Type: GrantFiled: November 30, 2012Date of Patent: May 3, 2016Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Patent number: 9328122Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 7-substituted fangchinoline derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: January 21, 2013Date of Patent: May 3, 2016Assignee: HANGZHOU BENSHENG PHARMACEUTICALS CO., LTD.Inventors: Frank Rong, Rongzhen Xu, Hongxi Lai, Fuwen Xie
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Patent number: 9249137Abstract: The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.Type: GrantFiled: August 25, 2011Date of Patent: February 2, 2016Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Publication number: 20150290232Abstract: The present invention belongs to the field of medicine and pharmaceutical chemistry, specifically relates to novel antitumor pharmaceutical combination, and particularly relates to pharmaceutical combination of bisbenzylisoquinoline alkaloids (e.g. berbamine and tetrandrine) and anthracene compounds (e.g. aclarubicin A) and their use in treating tumors.Type: ApplicationFiled: September 27, 2013Publication date: October 15, 2015Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie
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Patent number: 9156801Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-substituted oleanolic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: November 30, 2012Date of Patent: October 13, 2015Assignee: Hangzhou Bensheng Pharmaceutical Co., Ltd.Inventors: Rongzhen Xu, Frank Rong, Hongxi Lai, Fuwen Xie
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Patent number: 9133207Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 5-substituted tetrandrine derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: August 20, 2012Date of Patent: September 15, 2015Assignee: Hangzhou Bensheng Pharmaceutical Co., Ltd.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Publication number: 20150238488Abstract: The present invention belongs to the field of medicine and pharmaceutical chemistry, specifically relates to novel antitumor pharmaceutical combinations, and particularly relates to pharmaceutical combinations of bisbenzylisoquinoline alkaloids (e.g. berbamine and tetrandrine) and imatinib mesylates and their use in treating tumors.Type: ApplicationFiled: September 27, 2013Publication date: August 27, 2015Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie
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Publication number: 20150152133Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel Polyphyllin I derivatives of formula (I) that is acylated at the 5?-position of arabinofuranosyl or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: ApplicationFiled: June 13, 2013Publication date: June 4, 2015Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie
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Publication number: 20150126552Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When X is nitrogen, formula I indicates 2-aminated methylene tanshinone I; when X is oxygen, formula I indicates 2-esterified methylene tanshinone I.Type: ApplicationFiled: November 30, 2012Publication date: May 7, 2015Applicant: Hangzhou Bensheng Pharmaceutical Co., Ltd.Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Patent number: 8987502Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel amidated derivatives of oleanolic acid according to formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: GrantFiled: November 30, 2012Date of Patent: March 24, 2015Assignee: Hangzhou Bensheng Pharmaceutical Co., Ltd.Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
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Patent number: 8987288Abstract: The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.Type: GrantFiled: September 9, 2011Date of Patent: March 24, 2015Assignee: Hangzhou Bensheng Pharmaceutical Co., Ltd.Inventors: Rongzhen Xu, Fuwen Xie, Hongxi Lai, Frank Rong