Abstract: A system for transmitting an audio signal in a vehicle includes a stabilizer located at a source position in the vehicle. At least one speaker is operatively connected to the stabilizer. The speaker is adapted to transmit an audio signal to a target position for at least partially supporting a spatial audio representation. The target position and the source position are independently movable. The stabilizer is adapted to direct the audio signal such that a trajectory between the target position and the source position is maintained regardless of respective motion of the target position and the source position. The trajectory includes a first segment between the source position and a deflecting surface and a second segment between the deflecting surface and the target position.

Abstract: A gas turbine engine unit (110) for use in a modular power generation system includes an engine package (112) and a mechanical handling system adapted to convey components (114) out of and into the engine package (112). The engine package (112) includes a floor (132), a plurality of side walls (136), and a ceiling (134) that cooperate to define a sheltered space (140) sized to receive a gas turbine engine. The mechanical handling system includes rails (121) adapted to support components (114) conveyed out of and into the sheltered space (140) defined by the engine package (112).

Abstract: In one example, a method for printing a three-dimensional (3D) object is described. The method may include a processor depositing a layer of a sinterable material on a support member, and preheating the layer of the sinterable material using a moveable radiation source. The method may further include the processor depositing a fusing agent on an imaged area of the layer of the sinterable material and fusing the imaged area of the layer of the sinterable material using the moveable radiation source.

Abstract: The present invention provides nucleic acid and protein sequences that enhance the expression of fusion proteins by host cells, and in particular bacterial species, together with methods use thereof. While described hereinafter in terms of expression of fusion proteins by Listeria monocytogenes, the present invention is applicable to expression of fusion proteins generally.

Abstract: An implantable access port for use in transferring fluid transdermally between an external fluid storage or dispensing device and a site within a patient is disclosed. The access port includes a body, at least two reservoirs defined within the access port body, and at least one septum secured to the body and enclosing the reservoirs within the body. The access port also includes reservoir outlets defined within the reservoirs. The access port also has body conduits defined within the body and in fluid communication with the reservoir outlets and external openings defined in the exterior of the body. An implantable access port and system for use in apheresis is also provided that includes an implantable access port, at least one needle, and a catheter that is fluidly connected to the access port.

Abstract: Provided is a reusable tie down storage case including a housing having a tie down storage area and first and second strap storage areas, at least one tab in the tie down area for engaging a tie down, a first movable flap covering the first strap storage area to prevent removal of a first strap, and a second movable flap covering the second strap storage area to prevent removal of the second strap. The reusable case can be used as a retail package and as a reusable case after purchase to hold the tie downs in the case without an additional fastener.

Abstract: Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to fusion proteins comprising an epidermal growth factor receptor variant III (EGFRvIII) polypeptide and a mesothelin polypeptide, and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins. In some embodiments, the nucleic acid molecules can encode an EGFRvIII-mesothelin fusion protein comprising an amino acid sequence that is at least i) 90% identical, ii) 95% identical, or iii) 99% identical to EGFRvIIIx5-mesothelin35-622 as set forth in SEQ ID NO:8.

Abstract: In one example, a method for printing a three-dimensional (3D) object is described. The method may include a processor depositing a layer of a sinterable material on a support member, and preheating the layer of the sinterable material using a moveable radiation source. The method may further include the processor depositing a fusing agent on an imaged area of the layer of the sinterable material and fusing the imaged area of the layer of the sinterable material using the moveable radiation source.

Abstract: Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.

Abstract: Provided is a reusable tie down storage case including a housing having a tie down storage area and first and second strap storage areas, at least one tab in the tie down area for engaging a tie down, a first movable flap covering the first strap storage area to prevent removal of a first strap, and a second movable flap covering the second strap storage area to prevent removal of the second strap. The reusable case can be used as a retail package and as a reusable case after purchase to hold the tie downs in the case without an additional fastener.

Abstract: The present invention provides nucleic acid and protein sequences that enhance the expression of fusion proteins by host cells, and in particular bacterial species, together with methods use thereof. While described hereinafter in terms of expression of fusion proteins by Listeria monocytogenes, the present invention is applicable to expression of fusion proteins generally.

Abstract: Provided is a reusable tie down storage case including a housing having a tie down storage area and first and second strap storage areas, at least one tab in the tie down area for engaging a tie down, a first movable flap covering the first strap storage area to prevent removal of a first strap, and a second movable flap covering the second strap storage area to prevent removal of the second strap. The reusable case can be used as a retail package and as a reusable case after purchase to hold the tie downs in the case without an additional fastener.

Abstract: An implantable access port for use in transferring fluid transdermally between an external fluid storage or dispensing device and a site within a patient is disclosed. The access port includes a body, at least two reservoirs defined within the access port body, and at least one septum secured to the body and enclosing the reservoirs within the body. The access port also includes reservoir outlets defined within the reservoirs. The access port also has body conduits defined within the body and in fluid communication with the reservoir outlets and external openings defined in the exterior of the body. An implantable access port and system for use in apheresis is also provided that includes an implantable access port, at least one needle, and a catheter that is fluidly connected to the access port.

Abstract: Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.

Abstract: The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues.

Abstract: A gas turbine engine unit (110) for use in a modular power generation system includes an engine package (112) and a mechanical handling system adapted to convey components (114) out of and into the engine package (112). The engine package (112) includes a floor (132), a plurality of side walls (136), and a ceiling (134) that cooperate to define a sheltered space (140) sized to receive a gas turbine engine. The mechanical handling system includes rails (121) adapted to support components (114) conveyed out of and into the sheltered space (140) defined by the engine package (112).

Abstract: The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues.

Abstract: The present invention provides facultatively attenuated bacterial species and methods of preparation and use thereof. The term “facultatively attenuated” as used herein refers to a bacterium which comprises a set of defined recombinant modifications which have substantially no effect on the ability of the bacterium to grow by multiplication when the bacterium is outside of its host organism, but which result in deletion of one or more genes essential for multiplication of the bacterium when the bacterium is introduced into its host organism, for example within host cells of a vaccinate recipient. These recombinant modifications take advantage of regulatory sequences which preferentially induce expression of genes within the mammalian host.