Abstract: In one aspect, this invention relates to a method for treating pain and subsequent resulting conditions. In yet another aspect, this invention relates to formulating agents to rapidly reverse painful conditions.

Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.

Abstract: A transmitting element for generating a magnetic field for tracking of an object includes a first spiral trace that extends from a first outer origin inward to a central origin in a first direction. A second spiral trace can extend from the central origin outward to a second outer origin in the first direction. The second spiral trace can extend from the central origin to the second outer origin in the first direction. The first spiral trace and the second spiral trace can be physically connected at the central origin to form the fluorolucent magnetic transmitting element and at least a portion of the first spiral trace overlaps at least a portion of the second spiral trace.

Abstract: A trocar assembly can include a cannula, a seal cartridge, and an obturator. The seal cartridge is configured to be releasably coupled to the cannula and to be disposed at least partially within the cannula in a coupled configuration of the seal cartridge. The obturator is configured to directly latch to the cannula and to extends through the cannula and the seal cartridge in a coupled configuration of the obturator.

Abstract: A mixing system for a power washer includes an electrically actuated valve communicated with a supply of a working fluid, and having a valve head that is movable between open and closed positions to control the flow rate of the working fluid through an outlet of the valve. The outlet of the valve is communicated with a fluid passage of the power washer to enable flow of the working fluid into a primary fluid and discharge of a mixture of the primary fluid and working fluid from the power washer when the valve is open, and to provide a flow of primary fluid from the power washer when the valve is closed.

Abstract: In a method for advanced identification of a customer, a customer may remotely place an order, intending to later go to a store to pick up the ordered item. The store may have a pick-up area (e.g., at the back of the store) where the customer can go to pick up the ordered item. To save the customer time, the customer may be identified when she enters the store so that an employee can obtain her ordered item and have it ready to pick up by the time the customer walks through the store and arrives at the pick-up area.

Abstract: There is provided a two part hardenable composition comprising a powder first part and a liquid second part. The parts are operable to form a glass ionomer cement which hardens to a solid mass upon mixing of the parts together. The composition comprises an inorganic glass and/or salt in the powder first part, an aqueous carrier in the liquid second part and an acid-functional polymer in the powder first part and/or the liquid second part. The composition also comprises an at least partially water-miscible additive in the first and/or second parts. The additive is operable to extend the working time of the glass ionomer cement upon mixing of the first and or second parts. The composition is operable to form a glass ionomer cement which, once hardened to a solid mass, has a plane strain fracture toughness of at least 0.7 MPa·m1/2 as measured at 24 hours from mixing. Also provided is a method of producing a glass ionomer cement.

Abstract: A transmitting element for generating a magnetic field for tracking of an object includes a first spiral trace that extends from a first outer origin inward to a central origin in a first direction. A second spiral trace can extend from the central origin outward to a second outer origin in the first direction. The second spiral trace can extend from the central origin to the second outer origin in the first direction. The first spiral trace and the second spiral trace can be physically connected at the central origin to form the fluorolucent magnetic transmitting element and at least a portion of the first spiral trace overlaps at least a portion of the second spiral trace.

Abstract: A method of altering corneal tissue includes creating an electrochemical reaction in the tissue, wherein the electrochemical reaction occurs in the presence of an electrolytic solution in or on the tissue.

Abstract: A method of altering adipose tissue includes creating an electrochemical reaction in the tissue, wherein the electrochemical reaction occurs in the presence of an electrolytic solution in the tissue.

Abstract: A differential assembly provided with a power distribution unit includes a first housing, an output shaft, a shaft, and a torque limiter. The first housing defines a biasing member bore and a brake bore. The output shaft extends at least partially through the first housing. The shaft is disposed about the output shaft and extends between a first shaft end that is connected to a differential unit and a second shaft end. The torque limiter is disposed within the first housing and is arranged to selectively inhibit rotation of at least one of the output shaft and the shaft.

Abstract: A method of modifying a tissue includes providing an electrochemical reaction in the tissue by the use of an anodic electrode and a cathodic electrode wherein at least one of the anodic and cathodic electrodes is in contact with the tissue; and setting a concentration of electrochemically generated chemical agents that affect the tissue.

Abstract: Various embodiments are directed to techniques for organizing fulfillment of enterprise products, such as by using a request manager informed by enterprise resources and resource utilization to recommend a facility to fulfill a product request. Some embodiments are directed to identifying a product request and determining the equipment and skills necessary to fulfill the product request. Based on this information and location data, embodiments may determine a set of facilities as candidates to fulfill the request. A machine learning model may be used to analyze current resource utilization of the facilities and predict facility availability and estimated completion times for the request fulfillment. A candidate facility may be recommended for fulfillment of a request based on facility availability and estimated completion times. In some embodiments, historical resource utilization may be used to inform further staffing and equipment service decisions.

Abstract: A semiconductor device includes a semiconductor substrate configured to include a channel, a gate supported by the semiconductor substrate to control current flow through the channel, a first dielectric layer supported by the semiconductor substrate and including an opening in which the gate is disposed, and a second dielectric layer disposed between the first dielectric layer and a surface of the semiconductor substrate in a first area over the channel. The gate may be configured to include a lateral overhang that is separated from an upper surface of the first dielectric layer.

Abstract: Various embodiments are directed to techniques for organizing fulfillment of enterprise products, such as by using a request manager informed by enterprise resources and resource utilization to recommend a facility to fulfill a product request. Some embodiments are directed to identifying a product request and determining the equipment and skills necessary to fulfill the product request. Based on this information and location data, embodiments may determine a set of facilities as candidates to fulfill the request. A machine learning model may be used to analyze current resource utilization of the facilities and predict facility availability and estimated completion times for the request fulfillment. A candidate facility may be recommended for fulfillment of a request based on facility availability and estimated completion times. In some embodiments, historical resource utilization may be used to inform further staffing and equipment service decisions.

Abstract: A method of intervention in a failed deep-set tubing-retrievable subsurface safety valve disposed in a deepwater or ultra-deepwater subsea well uses a deep-set wireline-retrievable subsurface safety valve that may be deployed via wireline into the failed deep-set tubing-retrievable subsurface safety valve. The deep-set wireline-retrievable subsurface safety valve has a closure actuation mechanism that is disposed below the closure device. In addition, the closure actuation mechanism includes a pressure-balanced piston that is exposed to wellbore fluids on both distal ends of the piston, thereby allowing the piston to actuate the closure device in deepwater and ultra-deepwater wells with significant hydrostatic head in the control line.

Abstract: Various embodiments are directed to techniques for organizing fulfillment of enterprise products, such as by using a request manager informed by enterprise resources and resource utilization to recommend a facility to fulfill a product request. Some embodiments are directed to identifying a product request and determining the equipment and skills necessary to fulfill the product request. Based on this information and location data, embodiments may determine a set of facilities as candidates to fulfill the request. A machine learning model may be used to analyze current resource utilization of the facilities and predict facility availability and estimated completion times for the request fulfillment. A candidate facility may be recommended for fulfillment of a request based on facility availability and estimated completion times. In some embodiments, historical resource utilization may be used to inform further staffing and equipment service decisions.

Abstract: A differential assembly provided with a power distribution unit includes a first housing, an output shaft, a shaft, and a torque limiter. The first housing defines a biasing member bore and a brake bore. The output shaft extends at least partially through the first housing. The shaft is disposed about the output shaft and extends between a first shaft end that is connected to a differential unit and a second shaft end. The torque limiter is disposed within the first housing and is arranged to selectively inhibit rotation of at least one of the output shaft and the shaft.

Abstract: A subsurface safety valve system for a wellbore is described. The system can include a tubular housing disposed within the wellbore having a cavity running in a longitudinal direction therethrough. The system can also include an electromagnetic device configured to receive electric power to create a magnetic field, and a flapper operative to open and close the cavity in response to the electric power received by the electromagnetic device. The flapper may open in response to the electric power exceeding a first electric power value and remain open in response to the electric power exceeding a second electric power value which is lower than the first electric power value.

Abstract: An injection sleeve and apparatus for injecting fluid into a well includes a flow tube having a piston which upon fluid flow opens one or more outlet ports. The injection sleeve is adapted to include a variable orifice insert which prevents flow through the tool at a first selected pressure level until the outlet ports are in an open position, thereby protecting packing seals on either side of the outlet ports from undue wear and tear, and prolonging the life of the tool. At a second pressure level, the variable orifice insert permits flow through injection sleeve to the formation injection zones. A plurality of the sleeves may be used for sequentially injecting fluid into a plurality of injection formation zones surrounding a well. When injection fluid flow is terminated, the injection sleeves act as a dual barrier valve for preventing flow from the injection formation zones back to the well head.