Abstract: The present invention relates to an enteric coated pharmaceutical composition comprising a solid dispersion comprising regorafenib and at least one stabilizing agent outside of the solid dispersion, its process of preparation and its use for treating disorders.

Abstract: An apparatus for rolling strip having a periodically fluctuating strip thickness has a roll stand with a set of rollers defining a gap, an adjustment actuator for adjusting the gap of the set of rollers, unwinder for feeding the strip with an initial thickness to an intake side of the roller gap, winder for receiving the strip with a desired final thickness from an output side of the gap, respective upstream and roller assemblies each having an immersion roller provided upstream of the roll stand between the unwinder and the roll stand and downstream of the roll stand between the roll stand and the winder. The strip is guided around the immersion rollers. A controller sets positions of the immersion rollers while operating the rollers of the roll stand at a constant roller speed, for determining the roller gap in dependence on the setting of the rollers.

Abstract: An apparatus for rolling strip having a periodically fluctuating strip thickness has a roll stand with a set of rollers defining a gap, an adjustment actuator for adjusting the gap of the set of rollers, unwinder for feeding the strip with an initial thickness to an intake side of the roller gap, winder for receiving the strip with a desired final thickness from an output side of the gap, respective upstream and roller assemblies each having an immersion roller provided upstream of the roll stand between the unwinder and the roll stand and downstream of the roll stand between the roll stand and the winder. The strip is guided around the immersion rollers. A controller sets positions of the immersion rollers while operating the rollers of the roll stand at a constant roller speed, for determining the roller gap in dependence on the setting of the rollers.

Abstract: The present invention relates to a process to prepare a dried vegetable product comprising the steps of —subjecting a vegetable to a hypertonic heat shock by contacting (preferably submerging) the vegetable with (in) a hypertonic heat shock solution comprising at least one edible salt, at a temperature of 101 to 112 degrees C.; —coating the hypertonically heat shocked vegetable with a coating mix and —drying the coated hypertonically heat shocked vegetable.

Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

Abstract: The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.

Abstract: The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains.

Abstract: The present invention relates to a test system for measuring MEST activity, a method for screening for a ligand for MEST and the use of the test system for the identification of a MEST ligand, particularly a MEST inhibitor.

Abstract: The present invention relates to a process to prepare a dried vegetable product comprising the steps of—subjecting a vegetable to a hypertonic heat shock by contacting (preferably submerging) the vegetable with (in) a hypertonic heat shock solution comprising at least one edible salt, at a temperature of 101 to 112 degrees C.;—coating the hypertonically heat shocked vegetable with a coating mix and—drying the coated hypertonically heat shocked vegetable.

Abstract: A platform for industrial installations, in particular for high-pressure descalers (3a) or other machines (3) with optionally bundled supply, discharge, and/or distribution conduits (11) which in operational position, are connectable with fixed conduits of a respective machine (3), can be provided as a central installation for connecting media and power lines that can be monitored and easily inspected, with an arrangement being carried out in an immediate proximity with predetermined distance, lateral position and height with regard to a connectable machine (3) with control units (4), devices (4), drives (5) and drive consoles (5a), distribution blocks (6), valve units (7), control elements and the like being distributed over a horizontal, polygonal platform foundation surface (2) according to their functions with regard to the machine (3).

Abstract: The present invention is directed to a device for quantitative analysis of an analyte in a liquid sample by detecting a magnetic label, an instrument for controlling the analysis process and displaying the results and a method for performing said analysis with said device and said instrument.

Abstract: An apparatus and a method for automatic detection of particles, in particular, biological particles such as micro-organisms. The apparatus has a device for binding the particles to separating particles which can be bound selectively to the particles. The apparatus further includes a separating device for extraction of the separating particles with bound particles from a collecting fluid, and a detection unit for detecting a number and/or concentration of the particles separated in this manner. The device for binding the particles to the separating particles includes a collecting device for collecting a collecting fluid including the separating particles and the particles that are provided by a particle-fluid mixture.

Abstract: The invention relates to a descaling device which can be operated in an optimal manner with respect to the efficiency, descaling quality, energy and water consumption and is readily available. The aim of the invention is achieved such that the spray nozzles (12), which are instrumental in descaling the steel material (2) in the descaling device (8), are designed as static nozzles and as dynamic or rotating nozzles. The static nozzles form, together with the spray bars, pairs of spray bars (13) and the dynamic or rotating nozzles form, together with spray units, rows of pairs of spray units (23).

Abstract: The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDIGs of the cells of a] are prepared; c] the hcDIGs from b] are incubated with a chemical compound; d] the activity of the GPI-PLC from the hcDIGs of c] is determined.

Abstract: The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.

Abstract: In an embodiment, a fiduciary deposit business object may be used to manage data relating to cash flow instruments. The business object may be structured in an embodiment to include a plurality of tables, including transaction, collateral, activity, cash flow, and/or adjustment tables. In an embodiment, when a settlement activity is recorded in the business object, a financial calculation procedure may be initiated. The financial calculation procedure may use data stored in the tables in a financial calculation, such as a gain/loss calculation, based on the location of the data in a specific table, such as whether the data was recently added. After completing the financial calculation, data in the business object may be updated and/or a result may be sent to an accounting system. Additional data, such as data in the collateral and other tables, may also be sent to the accounting system depending on accounting reporting requirements.

Abstract: The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.

Abstract: A flavor enhances for savory food products. A sodium-free and glutamate-free flavor enhance comprising a) an amino acid selected from arginine and/or lysine b) adipic acid C) 50-80% (wt) Kcl d) Optionally an ammonium salt.

Abstract: Disclosed are compounds of the general formula (I), with the definitions of the substituents R1 to R5, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).