Abstract: A surgical staple for inserting into one or more bone parts comprises a plate, a first screw and a second screw. The plate includes a first end, an opposed second end, a first aperture that is positioned near the first end, and a second aperture that is positioned near the second end. Additionally, the plate is curved along a length of the plate from the first end to the second end. The first screw extends through the first aperture. The second screw extends through the second aperture. Further, the first screw and the second screw are angled toward one another when the surgical staple is in a relaxed configuration.

Abstract: A method is provided for sterile packaging of a Kirschner wire (K-wire) and cap for shipping and storage, such that the K-wire and cap may be removed from the sterile packaging and used during a surgery. The method comprises sterile packaging the K-wire into a first container, sterile packaging the cap into a second container, and then bundling the first and second containers into a third container. In some embodiments, the first container may be comprised of a sterile interior environment within a double tube container, and the second container may be comprised of peel pouch configured to be unsealed during the surgery. In some embodiments, the K-wire and the cap may be placed together onto a mounting card that is then sterile packaged into a peel pouch that may be unsealed during the surgery.

Abstract: A system and methods are provided for treating radial head fractures. The system includes an implant, a sterile instrument kit for radial head arthroplasty, and a head sizer and assembly tray for sizing and assembling implants. The implant includes a head that is coupled with a stem. The head is adapted to be placed into sliding contact with a capitellum of the radiocapitellar joint. The stem is configured to be inserted into a hole reamed into a medullary canal of the radial head. The sterile instrument kit comprises a multiplicity of instruments including any one or more of trial heads and trial stems, a starter awl, a reamer, a planar, an inserter cap, and an impactor. The instruments are configured for implanting the implant into the radiocapitellar joint such that the implant restores biomechanical properties of the joint.

Abstract: A no-sting skin protectant film forming composition is formulated with a film forming polymer having both polar and nonpolar characteristics, a no-sting nonpolar solvent system, and at least one skin health ingredient. The no-sting skin protectant film forming composition is configured to form a protective film on a skin surface after the solvent system evaporates.

Abstract: A marine propulsion system includes a marine drive having an electric motor powerhead, at least one marine battery, at least a first connection cable having a connector configured to removably connect to a drive port on a housing of the marine drive, and an interlock circuit. The interlock circuit is configured to provide a completed circuit when the at least one battery and the marine drive are connected via at least the first connection cable, wherein the interlock circuit is independent from a power circuit delivering power from the at least one marine battery to the marine drive. The at least one battery is configured to identify whether the interlock circuit is completed and to control an internal disconnect to connect to the power circuit when the interlock circuit is completed and to disconnect from the power circuit when the interlock circuit is opened.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: An example method is performed by a first medical device and includes generating first data indicating a physiological parameter of a subject; generating a filter configured to remove an artifact associated with a treatment; and generating second data by applying the filter to the first data. The example method further includes determining that a second medical device is administering the treatment to the subject. In response to determining that the second medical device is administering the treatment to the subject, the first medical device outputs an indication that filtering is available; receives an input signal selecting the filtering; and in response to receiving the input signal, displays the second data.

Abstract: An example method is performed by a medical device and includes detecting an analog signal indicating a physiological parameter of a subject; converting the analog signal to first data; and determining a treatment parameter characterizing a treatment administered to the subject by a second medical device. The method further includes generating a filter characterized by the treatment parameter; generating second data by applying the filter to the first data; and displaying, on a user interface, the first data and the second data, wherein the second data is emphasized on the user interface.

Abstract: An example method is performed by a computing device executing instructions stored in data storage, and includes receiving physiologic monitoring data from a plurality of sensors coupled to a patient, receiving information indicating a measurement of patient motion during the patient care event, determining whether the measurement of patient motion is above a threshold, based on determining whether the measurement of patient motion is above the threshold, generating, for the physiologic monitoring data, a respective quality indicator, analyzing, by the computing device, (i) a combination of the physiologic monitoring data from the plurality of sensors and (ii) the respective quality indicator for the physiologic monitoring data to generate a response dependent upon the combination of the physiologic monitoring data as weighted by the respective quality indicator, and based on analyzing, outputting caregiver feedback by the computing device according to the response.

Abstract: Various systems, methods, and devices related to modifying views of a multi-lead electrocardiogram (ECG), as well as identifying notations associated with the multi-lead ECG, are described. An example method includes displaying graphical elements in a first arrangement. The graphical elements respectively depict electrical signals indicative of an electrical activity of a heart. The example method further includes detecting a signal indicative of a display selection, and, based on the display selection, rearranging the graphical elements from the first arrangement to a second arrangement.

Abstract: A wearable cardioverter defibrillator monitor case includes a housing configured to surround a defibrillator electronics assembly, a front cover removably attachable to the housing, and a rear cover removably attachable to the housing. The wearable cardioverter defibrillator case has a shock indicator positioned on the housing at an interface between the housing and the front cover.

Abstract: There is provided a fit testing method comprising: providing a respirator donned by a wearer; providing a sensor in electrical communication with a sensing element, where the sensor is configured to monitor a particulate concentration parameter of a gas space within the respirator, and a second particulate concentration parameter of a gas space outside the respirator, where the sensor is attached to the respirator such that the respirator such that the weight of the sensor is supported by the respirator; and providing a reader configured to communicate with the sensor, where the reader is configured to provide a respirator fit parameter based on a comparison of the particulate concentration within the respirator to the particulate concentration parameter outside the respirator.

Abstract: Systems and methods described herein relate to determining physiological parameters and associated reliability of the physiological parameters and displaying the data in a manner that conveys the reliability information to a user. The reliability index is determined and then used to determine one or more display attributes for displaying the underlying parameter data while also conveying the reliability information. The implementations described herein provide for displaying physiological parameters in a manner that is easily digested and understood while also conveying a reliability in such data, without filling or cluttering a display with background or additional data that is typically used in a manual method to evaluate the data on the display.

Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: A wearable cardioverter defibrillator monitor case includes a housing configured to surround a defibrillator electronics assembly, a front cover removably attachable to the housing, and a rear cover removably attachable to the housing. The wearable cardioverter defibrillator case has a shock indicator positioned on the housing at an interface between the housing and the front cover.