Patents by Inventor Gabriel O. Reznik
Gabriel O. Reznik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220259626Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid is for example 95% one length (C14, myristic).Type: ApplicationFiled: September 21, 2021Publication date: August 18, 2022Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Patent number: 11155843Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: March 18, 2020Date of Patent: October 26, 2021Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Publication number: 20210062234Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: ApplicationFiled: March 18, 2020Publication date: March 4, 2021Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Patent number: 10640799Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: May 14, 2018Date of Patent: May 5, 2020Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Publication number: 20180340198Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: ApplicationFiled: May 14, 2018Publication date: November 29, 2018Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Patent number: 9970036Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.Type: GrantFiled: March 14, 2014Date of Patent: May 15, 2018Assignee: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Publication number: 20160076065Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.Type: ApplicationFiled: March 14, 2014Publication date: March 17, 2016Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Publication number: 20030228623Abstract: In general, the invention provides novel methods for generating, selecting, and displaying small molecules on the surface of a virus or cell. The viruses or cells expressing these small molecules may be assayed to select the small molecules that bind a target molecule.Type: ApplicationFiled: September 27, 2002Publication date: December 11, 2003Inventors: Charles R. Cantor, Gabriel O. Reznik, Natalia E. Broude
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Patent number: 6368813Abstract: Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biotin.Type: GrantFiled: March 23, 2000Date of Patent: April 9, 2002Assignee: The Trustees of Boston UniversityInventors: Gabriel O. Reznik, Takeshi Sano, Sandor Vajda, Cassandra Smith, Charles Cantor
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Patent number: 6022951Abstract: The present invention relates to streptavidin proteins and peptides having a altered physical properties such as an increased stability or increased or decreased affinity for binding biotin. The invention also relates to methods for the detection, identification, separation and isolation of targets using streptavidin proteins or peptides. Streptavidin with increased or reduced affinity allows for the use of the streptavidin-biotin coupling systems for detection and isolation systems wherein it is necessary to remove of one or the other of the binding partners. Such systems are useful for the purification of functional proteins and viable cells. The invention also relates to nucleic acids which encode these streptavidin proteins and peptides and to recombinant cells such as bacteria, yeast and mammalian cells which contain these nucleic acids.Type: GrantFiled: April 10, 1996Date of Patent: February 8, 2000Inventors: Takeshi Sano, Charles R. Cantor, Sandor Vajda, Gabriel O. Reznik, Cassandra L. Smith, Mark W. Pandori