Patents by Inventor Gabriella Szabo

Gabriella Szabo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anticoagulant peptidyl-arginine aldehyde derivatives
    Patent number: 6235707
    Abstract: The invention relates to new peptidyl-arginine aldehyde compounds of formula (I) Q-D-Xaa-Pro-Arg-H  (I) wherein Q represents an acyl group of formula Q′—OCO, wherein Q′ represents an alkyl-group with 1-3 carbon atoms, D-Xaa represents a 3-cyclobutyl-D-alanyl- or 3-cyclopentyl-D-alanyl group, Pro represents an L-prolyl group, and Arg represents an L-arginyl group, and acid-addition salts thereof, and pharmaceutical compositions comprising them, which are suitable for the prevention and cure of thrombosis and accelerated blood clotting.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: May 22, 2001
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Sándor Bajusz, Attila Juhász, Éva Barabás, András Fehér, Gabriella Szabó, Erzsébet Széll née Hasenöhrl, Irén Véghelyi née Fauszt, Emilia Lavich née Oszko, Éva Kaszás, József Langó, Imre Moravcsik, Ágnes Szeker née Peszeky, Zsuzsanna Taschler née Pásztor, Gábor Tóth, Zsuzsanna Mohai née Nagy, Anna Mária Szalkay née Hollósi, Klára Makk née Ocskay
  • Anticoagulant peptide aldehyde derivatives
    Patent number: 6121241
    Abstract: This invention relates to peptide aldehyde derivatives of formula (I): D-Xaa-Pro-Arg-H, wherein Xaa represent a 2-cycloheptyl-2-hydroxyacetyl or 2-cyclopentyl-2-hydroxyacetyl group, Pro represents an L-prolyl residue and Arg represents an L-arginyl residue, their acid-additon salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. The compounds of formula (I) of the invention have therapeutic, particularly anticoagulant, antiplatelet and antithrombotic properties.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: September 19, 2000
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Sandor Bajusz, Attila Juhasz, Eva Barabas, Andras Feher, Gabriella Szabo, Erzsebet Szell nee Hasenohrl, Iren Veghelyi nee Fauszt, Emilia Lavich nee Oszko, Eva Kaszas, Jozsef Lango, Imre Moravcsik, Agnes Szeker nee Peszeky, Zsuzsanna Taschler nee Pasztor, Gabor Toth, Zsuzsanna Mohai nee Nagy, Anna Maria Szalkay nee Hollosi, Klara Makk nee Ocskay
  • Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof
    Patent number: 5760235
    Abstract: This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'--CH(OH)--CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: June 2, 1998
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Sandor Bajusz, Daniel Bagdy, Eva Barabas, Andras Feher, Gabriella Szabo, Gyorgyne Szell, Belane Veghelyi, Gyula Horvath, Attila Juhasz, Janosne Lavich, Laszlone Mohai, Imre Moravcsik, Gaborne Szeker, Istvan Pallagi, Katalin Palne Aranyosi
  • Transdermal compositions
    Patent number: 5380761
    Abstract: An anhydrous transdermal composition is disclosed comprising in a 20 to 100% lyotropic liquid crystalline arrangement:5 to 15 weight % of optically active or racemic N-methyl-N-(1-phenyl-2-propyl)-2-propynylamine or N-methyl-N-{1-(4-fluorophenyl)-2-propyl}-2-propynylamine or a pharmaceutically acceptable salt thereof;40 to 70% by weight of liquid polyethylene glycol;10 to 20% by weight of solid polyethylene glycol;2 to 30% by weight of a nonionic surface active agent;2 to 20% by weight of propylene glycol, and if desired,0.5 to 2% by weight of a polymer, the a value of which is greater than 0.6, andoptionally, in an amount needed up to 100% an emulsifying agent.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: January 10, 1995
    Assignee: Chinoin Gyogyszer- ES Vegyeszeti Termekek Gyara RT.
    Inventors: Szabo Anna Z., Gabriella Szabo nee Ujhelyi, Antal Toth, Tamas Szuts, Kalman Magyar, Jozsef Lengyel, Janos Pinter, Anna Szekely, Andras Szego, Katalin Marmarosi nee Kellner
  • 5H-2,3-Benzodiazepine derivatives
    Patent number: 4322346
    Abstract: New 5H-2,3-benzodiazepine derivatives of the formula ##STR1## wherein R is phenyl having a trifluoromethyl or halogen substituent,R.sup.1 is methyl,R.sup.2 is hydrogen,R.sup.3 is methoxy and R.sup.4 is methoxy, and the pharmaceutically acceptable acid addition salts thereof, are potent tranquilizers.
    Type: Grant
    Filed: September 26, 1980
    Date of Patent: March 30, 1982
    Inventors: Jeno Korosi, Tibor Lang, Jozsef Szekely, Ferenc Andrasi, Gabor Zolyomi, Jozsef Borsi, Katalin Goldschmidt nee Horvath, Tamas Hamori, Gabriella Szabo nee Czibula, Zsuzsanna Meszaros nee Dunai-Kovacs, Erzsebet Miglecz