Patents by Inventor Gad Keren
Gad Keren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220387009Abstract: The inventive device may include a delivery catheter that remains coupled to an expandable stent portion having an hourglass or “diabolo” shape. The temporary stent device is configured to lodge the shunt portion securely in the atrial septum, preferably the fossa ovalis, to function as an interatrial shunt, allowing blood flow between the left atrium to the right atrium responsive to a pressure differential across the atrial septum. Upon completion of the treatment, a delivery sheath may be used in conjunction with cinching cord coupled to the stent portion to retrieve and remove the temporary shunt device from the patient.Type: ApplicationFiled: June 1, 2022Publication date: December 8, 2022Applicant: V-Wave Ltd.Inventors: Nathan BUKHDRUKER, Nir NAE, Lior ROSEN, Erez ROZENFELD, James S. WHITING, Werner HAFELFINGER, Neal EIGLER, Gad KEREN
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Publication number: 20220338989Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, particular in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments, a control mechanism coupled to the adjustable flow regulation mechanism may be provided to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: July 8, 2022Publication date: October 27, 2022Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Patent number: 11382747Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, particular in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments, a control mechanism coupled to the adjustable flow regulation mechanism may be provided to remotely activate the adjustable flow regulation mechanism.Type: GrantFiled: March 4, 2022Date of Patent: July 12, 2022Assignee: V-Wave, Ltd.Inventors: Dan Rottenberg, Ori J. Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
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Publication number: 20220183838Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, particular in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments, a control mechanism coupled to the adjustable flow regulation mechanism may be provided to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: March 4, 2022Publication date: June 16, 2022Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Patent number: 11266501Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: GrantFiled: November 1, 2019Date of Patent: March 8, 2022Assignee: V-Wave Ltd.Inventors: Dan Rottenberg, Ori J. Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
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Publication number: 20220000620Abstract: A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is formed from a shape memory alloy and is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and first bottom gripping wings face each other to grip the annulus between them and the second top and second bottom gripping wings face each other to grip the annulus between them.Type: ApplicationFiled: July 19, 2021Publication date: January 6, 2022Inventors: Gad Keren, Allan C. Entis
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Patent number: 11065118Abstract: A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and bottom gripping wings face each other to grip the annulus between them and the second top and bottom gripping wings face each other to grip the annulus between them.Type: GrantFiled: March 4, 2014Date of Patent: July 20, 2021Assignee: The Medical Research, Infrastructure And Health Services Fund Of the Tel-Aviv Medical CenterInventors: Gad Keren, Allan C. Entis
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Publication number: 20210187258Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.Type: ApplicationFiled: March 4, 2021Publication date: June 24, 2021Applicants: The Medical Research, Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center, V-Wave Ltd.Inventor: Gad KEREN
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Publication number: 20210154012Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: February 3, 2021Publication date: May 27, 2021Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Patent number: 10940296Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.Type: GrantFiled: May 5, 2016Date of Patent: March 9, 2021Assignees: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center, V-Wave Ltd.Inventor: Gad Keren
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Patent number: 10912645Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: GrantFiled: May 19, 2020Date of Patent: February 9, 2021Assignee: V-Wave Ltd.Inventors: Dan Rottenberg, Ori J. Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
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Publication number: 20200276016Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: May 19, 2020Publication date: September 3, 2020Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Publication number: 20200060825Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: November 1, 2019Publication date: February 27, 2020Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Patent number: 10463490Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: GrantFiled: August 3, 2017Date of Patent: November 5, 2019Assignee: V-Wave Ltd.Inventors: Dan Rottenberg, Ori J. Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
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Patent number: 10226340Abstract: A method of replacing a native cardiac valve with a prosthetic cardiac valve, the method comprising: expanding a wire mesh scaffolding in a chamber of the heart on a retrograde side of the native cardiac valve; while the scaffolding is expanded on the retrograde side of the valve positioning the prosthetic cardiac valve at the site of the native cardiac valve; expanding the prosthetic cardiac valve to replace the native cardiac valve; and collapsing the scaffolding to a collapsed state and removing the collapsed scaffolding from the chamber of the heart.Type: GrantFiled: October 8, 2014Date of Patent: March 12, 2019Assignee: THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventor: Gad Keren
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Patent number: 10207087Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.Type: GrantFiled: January 13, 2014Date of Patent: February 19, 2019Assignee: HemoDynamx Technologies, Ltd.Inventors: Gad Keren, Randy Kesten
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Publication number: 20180280667Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.Type: ApplicationFiled: May 5, 2016Publication date: October 4, 2018Inventor: Gad Keren
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Publication number: 20180250131Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: August 3, 2017Publication date: September 6, 2018Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
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Patent number: 9943670Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.Type: GrantFiled: December 7, 2012Date of Patent: April 17, 2018Assignee: V-Wave Ltd.Inventors: Gad Keren, Randy Kesten
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Publication number: 20170325956Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: ApplicationFiled: August 3, 2017Publication date: November 16, 2017Applicant: V-Wave Ltd.Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN