Patents by Inventor Gail P. Mazzara

Gail P. Mazzara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for treating and preventing breast cancer
    Patent number: 8933041
    Abstract: The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: January 13, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
  • Custom vectors for treating and preventing pancreatic cancer
    Patent number: 8901093
    Abstract: The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains a foreign nucleic acid encoding at least one pancreatic tumor associated antigen (PTAA).
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: December 2, 2014
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
  • NOVEL INSERTION SITES IN POX VECTORS
    Publication number: 20100136056
    Abstract: The present invention provides novel insertion sites for introducing DNA into pox vectors.
    Type: Application
    Filed: December 16, 2009
    Publication date: June 3, 2010
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Patricia Greenhalgh
  • Insertion sites in fowlpox vectors
    Patent number: 7638134
    Abstract: The present invention provides novel insertion sites for introducing DNA into pox vectors.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: December 29, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Patricia Greenhalgh
  • Recombinant pox virus for immunization against tumor-associated antigens
    Patent number: 7410644
    Abstract: Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: August 12, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey Schlom, Dennis L. Panicali, Linda R. Gritz, Gail P. Mazzara
  • Custom Vectors for Treating and Preventing Pancreatic Cancer
    Publication number: 20080166367
    Abstract: The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains a foreign nucleic acid encoding at least one pancreatic tumor associated antigen (PTAA).
    Type: Application
    Filed: November 12, 2004
    Publication date: July 10, 2008
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
  • Recombinant pox virus for immunization against tumor-associated antigens
    Publication number: 20030003079
    Abstract: Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
    Type: Application
    Filed: July 17, 2002
    Publication date: January 2, 2003
    Inventors: Jeffrey Schlom, Dennis L. Panicali, Linda R. Gritz, Gail P. Mazzara
  • Self-assembled, defective, nonself-propagating viral particles
    Patent number: 6051410
    Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: April 18, 2000
    Assignee: Therion Biologics, Corp.
    Inventors: Gail P. Mazzara, Dennis L. Panicali, Bryan Roberts, Linda R. Gritz, Virginia Stallard, Anna Mahr
  • Parvovirus empty capsids
    Patent number: 5905040
    Abstract: Empty viral capsids, particularly animal parvoviral empty capsids, induce protective antibody response against the virus. The empty viral capsids are obtained by recombinant DNA techniques. Expression vectors are constructed containing structural genes encoding capsid proteins in self assembling form. Eukaryotic transfectants express self-assembled empty viral capsids which can be used to vaccinate against the virus or antigenically related species of the virus.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: May 18, 1999
    Assignee: Therion Biologics Corporation
    Inventors: Gail P. Mazzara, Antonia T. Destree, Dennis L. Panicali
  • Self assembled, defective, nonself-propagating viral particles
    Patent number: 5804196
    Abstract: Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous polypeptides in avian or non-avian cells. Preferably, the recombinant avipox virus is a fowlpox virus. The viral particles can also be used as immunogens and for targeted delivery of heterologous gene products and drugs.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 8, 1998
    Assignee: Therion Biologics Corporation
    Inventors: Gail P. Mazzara, Dennis L. Panicali, Bryan Roberts, Linda R. Gritz, Virginia Stallard
  • Self-assembled, defective, non-self-propagating lentivirus particles
    Patent number: 5747324
    Abstract: The present invention provides recombinant DNA viral vectors which co-express lentivirus genes encoding structural and enzymatic polypeptides capable of assembling into defective nonself-propagating viral particles. The viral DNA vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and genes.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: May 5, 1998
    Assignee: Therion Biologics Corporation
    Inventors: Gail P. Mazzara, Bryan Roberts, Dennis L. Panicali, Linda R. Gritz, Virginia Stallard, Anna Mahr
  • Self assembled defective non-self propagating lentiviral particles
    Patent number: 5736368
    Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective non-self-propagating lentiviral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Therion Biologics Corporation
    Inventors: Gail P. Mazzara, Bryan Roberts, Dennis L. Panicali, Virginia Stallard, Linda R. Gritz
  • Self assembled, defective, non-self-propagating lentivirus particles
    Patent number: 5631154
    Abstract: Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous polypeptides in avian or non-avian cells. Preferably, the recombinant avipox virus is a fowlpox virus. The viral particles can also be used as immunogens and for targeted delivery of heterologous gene products and drugs.
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: May 20, 1997
    Assignee: Therion Biologics, Incorporated
    Inventors: Gail P. Mazzara, Dennis L. Panicali, Bryan Roberts, Linda R. Gritz, Virginia Stallard, Anna Mahr
  • Self-assembled, defective, non-self-propagating lentivirus particles
    Patent number: 5614404
    Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: March 25, 1997
    Assignee: Theriod Biologics, Incorporated
    Inventors: Gail P. Mazzara, Bryan Roberts, Dennis L. Panicali, Virginia Stallard, Linda R. Gritz, Anna Mahe
  • Recombinant pseudorabies virus
    Patent number: 5242829
    Abstract: Monovalent and multivalent recombinant pox viruses which express immunogenic proteins of pseudorabies viruses are provided for use as live vaccines against pseudorabies virus. DNA vectors for recombination with pox virus to introduce one or more genes into a pox viral genome are also provided.
    Type: Grant
    Filed: March 6, 1990
    Date of Patent: September 7, 1993
    Assignee: Therion Biologics Corporation
    Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz