Patents by Inventor Galina Kovalevskaya

Galina Kovalevskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150010926
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 8, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 8802381
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: August 12, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20140087393
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: March 18, 2013
    Publication date: March 27, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 8420339
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: April 16, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20130011858
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 10, 2013
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 8163508
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: April 24, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20110300557
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: July 12, 2011
    Publication date: December 8, 2011
    Inventors: John O' Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 7993858
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: August 9, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20110159526
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: September 7, 2010
    Publication date: June 30, 2011
    Inventors: John O' Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 7790403
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: September 7, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20080108089
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: October 22, 2007
    Publication date: May 8, 2008
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Patent number: 7285391
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: October 23, 2007
    Assignee: The Trustees of Columbia Univeristy in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20070026466
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: September 27, 2006
    Publication date: February 1, 2007
    Inventors: John O'Connor, Galina Kovalevskaya, Steven Birken
  • Patent number: 7034124
    Abstract: This invention provides an antibody which specifically binds to hLH?cf without cross-reacting with hLH, hLH? or hCG?cf. In an embodiment, the monoclonal antibody is designated B505. In a further embodiment, the hybridoma cell line producing the monoclonal antibody B 505 is designated ATCC Accession No. 12000. This invention provides different uses of the antibodies. Finally, this invention provides a method for determining the amount of hLH?cf or hLH?cf-related molecule in a sample.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: April 25, 2006
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Steven Birken, John O'Connor, Galina Kovalevskaya
  • Patent number: 6927034
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: August 9, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20050042702
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: September 1, 2004
    Publication date: February 24, 2005
    Applicant: The Trustees of Columbia University
    Inventors: John Connor, Steven Birken, Galina Kovalevskaya
  • Publication number: 20020161198
    Abstract: This invention provides an antibody which specifically binds to hLH&bgr;cf without cross-reacting with hLH, hLH&bgr; or hCG&bgr;cf. In an embodiment, the monoclonal antibody is designated B505. In a further embodiment, the hybridoma cell line producing the monoclonal antibody B 505 is designated ATCC Accession No. 12000. This invention provides different uses of the antibodies. Finally, this invention provides a method for determining the amount of hLH&bgr;cf or hLH&bgr;cf-related molecule in a sample.
    Type: Application
    Filed: September 23, 1999
    Publication date: October 31, 2002
    Inventors: ROBERT E. CANFIELD, STEVEN BIRKEN, JOHN O'CONNOR, GALINA KOVALEVSKAYA
  • Patent number: 5976876
    Abstract: This invention provides an antibody which specifically binds to hLH.beta.cf without cross-reacting with hLH, hLH.beta. or hCG.beta.cf. In an embodiment, the monoclonal antibody is designated B505. In a further embodiment, the hybridoma cell line producing the monoclonal antibody B 505 is designated ATCC Accession No.12000. This invention provides different uses of the antibodies. Finally, this invention provides a method for determining the amount of hLH.beta.cf or hLH.beta.cf-related molecule in a sample.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: November 2, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Steven Birken, John O'Connor, Galina Kovalevskaya