Patents by Inventor Gamini Weeratunga

Gamini Weeratunga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of acalabrutinib
    Patent number: 10800787
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 13, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20200172514
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: February 6, 2020
    Publication date: June 4, 2020
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Acalabrutinib and Intermediates Thereof
    Publication number: 20200048264
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Application
    Filed: April 17, 2018
    Publication date: February 13, 2020
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the preparation of Veliparib and intermediates thereof
    Patent number: 10556887
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: February 11, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Dasotraline and Intermediates Thereof
    Publication number: 20190390235
    Abstract: The present invention provides processes for the preparation of Dasotraline, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the enzymatic transamination of a compound of Formula (2) to afford Dasotraline.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 26, 2019
    Inventors: Fabio E. S. Souza, Prabhudas Bodhuri, Eduardo Gustavo Cammisa, Gamini Weeratunga, Allan W. Rey
  • Processes for the preparation of apalutamide and intermediates thereof
    Patent number: 10513504
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: December 24, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of 3-(4-Halobutyl)-5-Cyanoindole
    Publication number: 20190330150
    Abstract: The present invention provides continuous flow processes for the preparation of the compound of Formula (1), an intermediate in the preparation of Vilazodone.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 31, 2019
    Inventors: Gamini Weeratunga, Avedis Karadeolian, Prabhudas Bodhuri, Dineshkumar N. Patel, Boris Gorin
  • Processes for the Preparation of Apalutamide and Intermediates Thereof
    Publication number: 20190276424
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Application
    Filed: March 6, 2019
    Publication date: September 12, 2019
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of lesinurad and intermediates thereof
    Patent number: 10351537
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: July 16, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Dasotraline and Intermediates Thereof
    Publication number: 20190194122
    Abstract: The present invention provides processes for the preparation of Dasotraline (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (2), or a salt thereof, and its deprotection to afford Dasotraline (1).
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Inventors: Prabhudas Bodhuri, Eduardo Gustavo Cammisa, Melanie R.A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20190119257
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: October 23, 2018
    Publication date: April 25, 2019
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Lesinurad and Intermediates Thereof
    Publication number: 20180258057
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of Tasimelteon and intermediates thereof
    Patent number: 9944616
    Abstract: The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1).
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 17, 2018
    Assignee: Apotex Inc.
    Inventors: Yajun Zhao, Murali Kondamreddy, Peter Garth Blazecka, Gamini Weeratunga, Craig Stewart, Nalini Nagireddy, Michael B. Johansen, Uma Kotipalli
  • Processes for the Preparation of Tasimelteon and Intermediates Thereof
    Publication number: 20170355688
    Abstract: The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1).
    Type: Application
    Filed: June 6, 2017
    Publication date: December 14, 2017
    Inventors: Yajun Zhao, Murali Kondamreddy, Peter Garth Blazecka, Gamini Weeratunga, Craig Stewart, Nalini Nagireddy, Michael B. Johansen, Uma Kotipalli
  • Processes for the Preparation of Rotigotine and Intermediates Thereof
    Publication number: 20170305877
    Abstract: The present invention provides processes for the preparation of a compound of Formula 2 or a salt thereof, wherein R1 is selected from the group consisting of H, C1-C3 alkyl, and C(0)R3; R3 is selected from the group consisting of C1-C6 alkyl, C6-C10aryl and C7-C20 arylalkyl; the carbon atom marked with “*” is racemic, enantiomerically enriched in the (R)-configuration, or enantiomerically enriched in the (S)-configuration. Also provided are intermediate compounds of the processes.
    Type: Application
    Filed: September 23, 2015
    Publication date: October 26, 2017
    Inventors: Michael B. Johansen, Probal Kanti Datta, Yajun Zhao, Gamini Weeratunga
  • Processes for the preparation of 3-alkyl indoles
    Patent number: 9533949
    Abstract: This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A1, A2 and A3 are independently selected from the group consisting of: H, X, OR1, CN, CONR22 and C02R3; R1 is C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: January 3, 2017
    Assignee: Apotex Pharmachem Inc.
    Inventors: Craig Stewart, Peter Garth Blazecka, Gamini Weeratunga, Uma Kotipalli, Sammy Chris Duncan, Yajun Zhao
  • Forms of vilazodone and processes for the preparation thereof
    Patent number: 9382233
    Abstract: Vilazodone hydrochloride benzyl alcohol solvates are provided as well as processes for the preparation thereof.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: July 5, 2016
    Assignee: Apotex Inc.
    Inventors: Gamini Weeratunga, Murali Kondamreddy, Allan W. Rey, Cameron L. McPhail, Yajun Zhao
  • Solid forms of nilotinib hydrochloride
    Patent number: 9376419
    Abstract: Disclosed are solid forms of Nilotinib hydrochloride and methods of preparation of various crystalline solvates of Nilotinib HCl including benzyl alcohol, acetic acid, propylene glycol, and isopropanol. Nilotinib HCl is a tyrosine kinase inhibitor used for the treatment of drug resistant chronic myelogenous leukemia (CML).
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: June 28, 2016
    Assignee: Apotex Inc.
    Inventors: Probal Kanti Datta, Carlos Zetina-Rocha, Cameron L. McPhail, Yajun Zhao, Gamini Weeratunga
  • SOLID FORMS OF NILOTINIB HYDROCHLORIDE
    Publication number: 20150274699
    Abstract: Disclosed are solid forms of Nilotinib hydrochloride and methods of preparation of various crystalline solvates of Nilotinib HCl including benzyl alcohol, acetic acid, propylene glycol, and isopropanol. Nilotinib HCl is a tyrosine kinase inhibitor used for the treatment of drug resistant chronic myelogenous leukemia (CML).
    Type: Application
    Filed: October 15, 2013
    Publication date: October 1, 2015
    Inventors: Probal Kanti Datta, Carlos Zetina-Rocha, Cameron L. McPhail, Yajun Zhao, Gamini Weeratunga
  • PROCESSES FOR THE PREPARATION OF 3-ALKYL INDOLES
    Publication number: 20150252000
    Abstract: This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A1, A2 and A3 are independently selected from the group consisting of: H, X, OR1, CN, CONR22 and C02R3; R1 is C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 10, 2015
    Inventors: Craig Stewart, Peter Garth Blazecka, Gamini Weeratunga, Uma Kotipalli, Sammy Chris Duncan, Yajun Zhao