Patents by Inventor Gandara Amarasinghe

Gandara Amarasinghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cooling garment
    Publication number: 20060276089
    Abstract: An article of clothing comprising a phase change material which is a blend of at least two compounds and which has a melting point of from 5 deg C. to 30 deg C., and a melting temperature range of from 1 to 5 deg. C.
    Type: Application
    Filed: July 16, 2004
    Publication date: December 7, 2006
    Applicant: Royal Melbourne Institute of Technology
    Inventors: Gandara Amarasinghe, Robert Shanks, Margaret Glewis, David Mainwaring, Dorothy Forster
  • Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylethyl-ethanolamine sulphonate esters as intermediates
    Patent number: 6288224
    Abstract: Aziridines may be subjeted to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I) where each R1 is independently hydrogen or a group AR and Ar is an optionally substituted phenyl group. The process comprises reacting a purified N-arylmethylethanolamine-sulphonate sulphonate ester with a base. N-aryimethyl-ethanolamine sulphonate ester of the formula R′NHCH2CH2OSO3H, wherein the N-arylmethyl group R′ is an N-(bisarylmethyl) or N-(triarylmethyl) group, as intermediates.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: September 11, 2001
    Assignees: Nycomed Salutar, Inc., University of Iowa Research Foundation
    Inventors: Janis Vasilevskis, John Varadarajan, Martha Garrity, Jere Douglas Fellmann, Louis Messerle, Gandara Amarasinghe
  • Preparation of N-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and N-arylmethyl-ethanol-amine sulphonate esters as intermediates
    Patent number: 6048979
    Abstract: Aziridines may be subjected to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I) where each R.sub.1 is independently hydrogen or a group AR and Ar is an optionally substituted phenyl group. The process comprises reacting a purified N-arylmethylethanolaminesulphonate ester with a base. N-arylmethyl-ethanolamine sulphonate ester of the formula R'NHCH.sub.2 CH.sub.2 OSO.sub.3 H, wherein the N-arylmethyl group R' is an N-(bisarylmethyl) or N-(triarylmethyl) group, as intermediates. In a further aspect, the invention provides compounds of formula (II) ##STR1## where Ar and R.sub.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: April 11, 2000
    Assignees: Nycomed Salutar, Inc., University of Iowa Foundation
    Inventors: Janis Vasilevskis, John Varadarajan, Martha Garrity, Jere Douglas Fellmann, Louis Messerle, Gandara Amarasinghe