Abstract: A medical screw, including: a first region comprising a constant diameter first root having a first diameter and a constant pitch multi-start thread; a second region forming a transition region; and a third region including a constant diameter root having the first diameter and a constant pitch thread, wherein the transition region is in between the first region and the second region and joins the first region with the second region, and wherein a lead of the constant pitch multi-start thread is different from a lead of the constant pitch thread.

Abstract: A surgical stapling device (10) is provided that includes a handle assembly (12), a movable trigger (26) and an elongated body portion (14). A staple containing shell assembly (22) is mounted on a distal end of the elongated body portion (14) and an anvil assembly (20) is movably mounted relative to the staple containing shell assembly (22). An auto-lock safety mechanism (40) is provided to prevent secondary actuation of the surgical stapling device after initial actuation. The auto-lock safety mechanism (40) includes a primary lock or slider assembly (42) for blocking movement of the trigger (26) and a secondary lock or stopper (44) for blocking movement of the slider assembly (42) prior to approximation of the anvil assembly (20) relative to the staple containing shell assembly (22). A slider (70) is urged to a locked or blocking position by a biasing member (72).

Abstract: An indicator (26) includes an indicator body portion (50), a pivot support member (52), a resilient lever (54) and an anchor (66). The pivot support member (52) has a first end (52a) secured to the indicator body portion (50) and a second end (52b) secured to a first end (54a) of the resilient lever (54). The resilient lever (54) has a second end (54b) secured to the anchor (66). The pivot support member (52) is adapted to be pivotally mounted to a body portion (18) of a surgical device and the anchor (66) is adapted to be secured to the surgical device such that pivotal movement of the indicator body portion (50) from a first position to a second position effects movement of the resilient lever (54) from a relaxed configuration to a stressed configuration. In the stressed configuration, the resilient lever (54) urges the indicator body portion (50) towards the first position. The indicator body portion (50) can be integrally molded of a plastic material to define a single part of unitary construction.

Abstract: An indicator (26) includes an indicator body portion (50), a pivot support member (52), a resilient lever (54) and an anchor (66). The pivot support member (52) has a first end (52a) secured to the indicator body portion (50) and a second end (52b) secured to a first end (54a) of the resilient lever (54). The resilient lever (54) has a second end (54b) secured to the anchor (66). The pivot support member (52) is adapted to be pivotally mounted to a body portion (18) of a surgical device and the anchor (66) is adapted to be secured to the surgical device such that pivotal movement of the indicator body portion (50) from a first position to a second position effects movement of the resilient lever (54) from a relaxed configuration to a stressed configuration. In the stressed configuration, the resilient lever (54) urges the indicator body portion (50) towards the first position. The indicator body portion (50) can be integrally molded of a plastic material to define a single part of unitary construction.

Abstract: A surgical stapling device (10) is provided that includes a handle assembly (12), a movable trigger (26) and an elongated body portion (14). A staple containing shell assembly (22) is mounted on a distal end of the elongated body portion (14) and an anvil assembly (20) is movably mounted relative to the staple containing shell assembly (22). An auto-lock safety mechanism (40) is provided to prevent secondary actuation of the surgical stapling device after initial actuation. The auto-lock safety mechanism (40) includes a primary lock or slider assembly (42) for blocking movement of the trigger (26) and a secondary lock or stopper (44) for blocking movement of the slider assembly (42) prior to approximation of the anvil assembly (20) relative to the staple containing shell assembly (22). A slider (70) is urged to a locked or blocking position by a biasing member (72).

Abstract: The present invention relates to an extended release solid oral pharmaceutical composition comprising Paliperidone or its pharmaceutically acceptable salts and process for preparing the same.