Patents by Inventor Ganesh M. Kishore
Ganesh M. Kishore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7335815Abstract: Methods are provided for producing plants and seeds having altered isoprenoid content and compositions. The methods find particular use in increasing the isoprenoid levels in plants, and in providing desirable isoprenoid compositions in a host plant cell.Type: GrantFiled: October 15, 2004Date of Patent: February 26, 2008Assignee: Calgene LLCInventors: Albert Boronat, Narciso Campos, Ganesh M. Kishore
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Patent number: 7195917Abstract: Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase. 3-? hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3?-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2?,3?-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.Type: GrantFiled: March 27, 2003Date of Patent: March 27, 2007Assignee: Monsanto Technology LLCInventors: Sherri M. Brown, Tedd D. Elich, Gregory R. Heck, Ganesh M. Kishore, Eugene W. Logusch, Sherry J. Logusch, Kenneth J. Piller, Sudabathula Rao, Joel E. Ream, Scott R. Baerson
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Patent number: 7192753Abstract: Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to ?-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.Type: GrantFiled: June 28, 2005Date of Patent: March 20, 2007Assignee: Monsanto Technology LLCInventors: Kenneth J. Gruys, Timothy A. Mitsky, Ganesh M Kishore, Steven C. Slater, Stephen R. Padgette, David M. Stark
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Patent number: 7105730Abstract: This invention relates to the field of biotechnology, particularly as it pertains to the production of sterols in a variety of host systems particularly plants. More specifically, the invention relates to nucleic acid molecules encoding proteins and fragments of proteins associated with sterol and phytosterol metabolism as well as the encoded proteins and fragments of proteins and antibodies capable of binding to them. The invention also relates to methods of using the nucleic acid molecules, fragments of the nucleic acid molecules, proteins, and fragments of proteins. The invention also relates to cells, organisms, particularly plants, or seeds, or progeny of plants, that have been manipulated to contain increased levels or overexpress at least one sterol or phytosterol compound.Type: GrantFiled: July 11, 2000Date of Patent: September 12, 2006Assignee: Monsanto Technology L.L.C.Inventors: Balasulojini Karunanandaa, Jaehyuk Yu, Ganesh M. Kishore
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Patent number: 7067647Abstract: Methods are provided for producing plants and seeds having altered isoprenoid content and compositions. The methods find particular use in increasing the isoprenoid levels in plants, and in providing desirable isoprenoid compositions in a host plant cell.Type: GrantFiled: November 13, 2001Date of Patent: June 27, 2006Assignee: Calgene LLCInventors: Albert Boronat, Narciso Campos, Ganesh M. Kishore
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Patent number: 6946588Abstract: Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to ?-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.Type: GrantFiled: August 30, 2001Date of Patent: September 20, 2005Assignee: Monsanto Technology LLCInventors: Kenneth J. Gruys, Timothy A. Mitsky, Ganesh M. Kishore, Steven C. Slater, Stephen R. Padgette, David M. Stark
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Patent number: 6822142Abstract: Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.Type: GrantFiled: June 20, 2001Date of Patent: November 23, 2004Assignee: Monsanto CompanyInventors: Balasulojini Karunanandaa, Martha Post-Beittenmiller, Mylavarapu Venkatramesh, Ganesh M. Kishore, Gregory M. Thorne, John R. LeDeaux
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Patent number: 6723897Abstract: Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase, 3-&bgr; hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing antisense RNA which suppresses the gibberellin biosynthetic pathway sequence. The antisense sequence is the complement of a copalyl diphosphate synthase sequence, a 3&bgr;-hydroxylase sequence, or a C20-oxidase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.Type: GrantFiled: August 10, 1999Date of Patent: April 20, 2004Assignee: Monsanto Technology, LLCInventors: Sherri M. Brown, Tedd D. Elich, Gregory R. Heck, Ganesh M. Kishore, Eugene W. Logusch, Sherry J. Logusch, Kenneth J. Piller, Sudabathula Rao, Joel E. Ream, Scott R. Baerson
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Publication number: 20040073976Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: ApplicationFiled: November 11, 2003Publication date: April 15, 2004Applicant: Monsanto Technology LLCInventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Patent number: 6716474Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: GrantFiled: August 6, 2001Date of Patent: April 6, 2004Assignee: Monsanto Technology LLCInventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Publication number: 20030233679Abstract: Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase. 3-&bgr; hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3&bgr;-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2&bgr;,3&bgr;-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.Type: ApplicationFiled: March 27, 2003Publication date: December 18, 2003Applicant: Monsanto Technology LLC.Inventors: Sherri M. Brown, Tedd D. Elich, Gregory R. Heck, Ganesh M. Kishore, Eugene W. Logusch, Sherry J. Logusch, Kenneth J. Piller, Sudabathula Rao, Joel E. Ream, Scott R. Baerson
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Patent number: 6663906Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: GrantFiled: June 6, 2002Date of Patent: December 16, 2003Assignee: Monsanto Technology LLCInventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Patent number: 6653530Abstract: Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid and tocopherol levels in oilseed plants, and in providing desirable high oleic acid seed oils.Type: GrantFiled: February 13, 1998Date of Patent: November 25, 2003Assignee: Calgene LLCInventors: Christine K. Shewmaker, B. Ganesh Bhat, Mylavaraapu Venkatramesh, Shaukat H. Rangwala, Ganesh M. Kishore, Sekhar S. Boddupalli
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Publication number: 20030150008Abstract: Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.Type: ApplicationFiled: June 20, 2001Publication date: August 7, 2003Inventors: Balasulojini Karunanandaa, Martha Post-Beittenmiller, Mylavarapu Venkatramesh, Ganesh M. Kishore, Gregory M. Thorne, John R. LeDeaux
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Publication number: 20030126641Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: ApplicationFiled: June 6, 2002Publication date: July 3, 2003Applicant: Monsanto Technology LLCInventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Publication number: 20030028917Abstract: Genes and methods for optimizing levels of substrates employed in the biosynthesis of copolymers of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) in plants and bacteria via manipulation of normal metabolic pathways using recombinant DNA techniques are provided. This is achieved through the use of a variety of wild-type and/or deregulated enzymes involved in the biosynthesis of aspartate family amino acids, and wild-type or deregulated forms of enzymes, such as threonine deaminase, involved in the conversion of threonine to P(3HB-co-3HV) copolymer endproduct. By these methods, enhanced levels of threonine, &agr;-ketobutyrate, propionate, propionyl-CoA, &bgr;-ketovaleryl-CoA, and &bgr;-hydroxyvaleryl-CoA are produced. Also provided are methods for the biological production of P(3HB-co-3HV) copolymers in plants and bacteria utilizing propionyl-CoA produced through a variety of engineered metabolic pathways.Type: ApplicationFiled: August 30, 2001Publication date: February 6, 2003Applicant: Monsanto Technology, LLC.Inventors: Kenneth J. Gruys, Timothy A. Mitsky, Ganesh M. Kishore, Steven C. Slater, Stephen R. Padgette, David M. Stark
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Publication number: 20020138875Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: ApplicationFiled: August 6, 2001Publication date: September 26, 2002Applicant: Monsanto Technology, LLC.Inventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Patent number: 6441277Abstract: Fructose-1,6-bisphosphate aldolase (FDA) is an enzyme reversibly catalyzing the reaction converting triosephosphate into fructose-1,6-bisphosphate. In the leaf, this enzyme is located in the chloroplast (starch synthesis) and the cytosol (sucrose biosynthesis). Transgenic plants were generated that express the E. coli fda gene in the chloroplast to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Leaves from plants expressing the fda transgene showed a significantly higher starch accumulation, as compared to control plants expressing the null vector, particularly early in the photoperiod, but had lower leaf sucrose. Transgenic plants also had a significantly higher root mass. Furthermore, transgenic potatoes expressing fda exhibited improved uniformity of solids.Type: GrantFiled: June 16, 1998Date of Patent: August 27, 2002Assignee: Monsanto Technology LLCInventors: Gerard F. Barry, Nordine Cheikh, Ganesh M. Kishore
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Patent number: RE38825Abstract: Genes encoding a glyphosate oxidoreductase enzyme are disclosed. The genes are useful in producing transformed bacteria and plants which degrade glyphosate herbicide as well as crop plants which are tolerant to glyphosate herbicide.Type: GrantFiled: July 7, 2000Date of Patent: October 11, 2005Assignee: Monsanto Technology LLCInventors: Gerard F. Barry, Ganesh M. Kishore
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Patent number: RE39247Abstract: Genes encoding Class II EPSPS enzymes are disclosed. The genes are useful in producing transformed bacteria and plants which are tolerant to glyphosate herbicide. Class II EPSPS genes share little homology with known, Class I EPSPS genes, and do not hybridize to probes from Class I EPSPS's. The Class II EPSPS enzymes are characterized by being more kinetically efficient than Class I EPSPS's in the presence of glyphosate. Plants transformed with Class II EPSPS genes are also disclosed as well as a method for selectively controlling weeds in a planted transgenic crop field.Type: GrantFiled: July 18, 2003Date of Patent: August 22, 2006Assignee: Monsanto Technology LLCInventors: Gerard F. Barry, Ganesh M. Kishore, Stephen R. Padgette, William C. Stallings