Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: Methods, systems, and devices for wireless communications are disclosed by the present application. A request to establish a call using a first connection may be received, the first connection using a first radio access technology to communicate with a radio access network. During execution of a procedure to establish the call, a command to handover communications from the first connection to a second connection that uses a second radio access technology to communicate with the radio access network may be received. The second connection may be established in response to the command, and a message indicating that the request to establish the call was successfully received may be transmitted over the second connection. Also, a message indicating that an alert of the call is being issued may be transmitted over the second connection.

Abstract: The present disclosure relates to a construction method for a deformable anchor cable capable of being prestressed. The anchor cable includes an outer sleeve, a shrinkage pipe, an inner sleeve, a steel strand, an anchor and a tray. When the anchor cable is in use, a hole is drilled first, then the anchor cable is mounted in the drilled hole, and finally a prestress is applied to the steel strand of the anchor cable. According to the construction method, the construction is convenient; the anchor cable has the characteristics of high strength and large deformation, and can be easily prestressed; and the large deformation is realized by squeezing the inner sleeve by means of the anchor, which completely overcomes the problem of breaking a cold-drawn rod during the large deformation process.

Abstract: Aspects of the disclosure provide an information processing apparatus that includes interface circuitry and processing circuitry. The interface circuitry is configured to obtain a text authored by a person. The processing circuitry is configured to analyze the text to obtain measurements of language features of the person, input the measurements of the language features into an evaluation model that is trained to predict a score as a function of the language features, determine a specific score for the person based on the evaluation model and output the specific score of the person for predicting a behavior of the person.

Abstract: Aspects of the disclosure provide an information processing apparatus that includes interface circuitry and processing circuitry. The interface circuitry is configured to obtain a text authored by a person. The processing circuitry is configured to analyze the text to obtain measurements of language features of the person, input the measurements of the language features into an evaluation model that is trained to predict a score as a function of the language features, determine a specific score for the person based on the evaluation model and output the specific score of the person for predicting a behavior of the person.