Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.

Abstract: The present disclosure is related to a microwave source. The microwave source may include a cathode heater and a thermionic emitter. The cathode heater may include a first component, and a second component enclosing at least a portion of the first component. The thermionic emitter may be configured to release electrons when the thermionic emitter is heated by the cathode heater. At least a portion of the second component of the cathode heater may be in contact with the thermionic emitter.

Abstract: This application provides a method for training a semantic understanding model, including: obtaining a first training sample set; performing denoising processing on the first training sample set to form a corresponding second training sample set; processing the second training sample set by using a semantic understanding model, to determine initial parameters of the semantic understanding model; processing the second training sample set by using the semantic understanding model in response to the initial parameters of the semantic understanding model, to determine update parameters of the semantic understanding model; and iteratively updating a semantic representation layer network parameter and a task-related output layer network parameter of the semantic understanding model by using the second training sample set and according to the update parameters of the semantic understanding model.

Abstract: An ear apparatus may comprise one or more of a housing, an electrode, a biometric sensor, a speaker driver, and/or other components. The housing of the ear apparatus may be configured to be attached to an ear. The electrode may be carried by the housing. The electrode may be configured to measure an electrical signal from the ear. The electrical signal may include a reference signal, a ground signal, or a bias signal. The biometric sensor may be carried by the housing. The biometric sensor may be configured to measure one or more biometric characteristics from the ear. The speaker driver may be carried by the housing. The speaker driver may be configured to produce sound.

Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.

Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.

Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.

Abstract: An ear apparatus may comprise one or more of a housing, an electrode, a biometric sensor, a speaker driver, and/or other components. The housing of the ear apparatus may be configured to be attached to an ear. The electrode may be carried by the housing. The electrode may be configured to measure an electrical signal from the ear. The electrical signal may include a reference signal, a ground signal, or a bias signal. The biometric sensor may be carried by the housing. The biometric sensor may be configured to measure one or more biometric characteristics from the ear. The speaker driver may be carried by the housing. The speaker driver may be configured to produce sound.

Abstract: A phase-change memory (PCM) device includes a first electrode, a second electrode, a memory layer, and a heater. The memory layer includes a phase-change material and is electrically coupled between the first electrode and the second electrode. The heater is arranged near the memory layer and is configured to heat a programming region of the memory layer in response to an electric current that passes through the heater. The heater is coupled to a power source via an electric current path that does not pass through the memory layer.

Abstract: A physically unclonable function (PUF) includes a bit cell that includes a latch and a switch to selectively couple the latch to a supply voltage node. A first transmission gate couples a first bit line to a first internal node of the latch and a second transmission gate couples a second bit line to a second internal node of the latch. A digital to analog converter (DAC) circuit is selectively coupled to the first internal node through the first bit line and the first transmission gate and to the second internal node through the second bit line and the second transmission gate, to thereby precharge the latch before the first bit cell is read. The latch regenerates responsive to the switch being closed to connect the latch to the supply voltage node. The first and second bit lines are used to read the regenerated value of the latch.

Abstract: A circuit board and a manufacturing method therefor. The circuit board includes a substrate and a plurality of traces arranged at intervals on the substrate. Each trace includes a seed layer located on one surface of the substrate, a first copper layer located on the surface of the seed layer away from the substrate, and a second copper layer plated on one surface of the substrate. The second copper layer covers the seed layer and the first copper layer. The ratio of the thickness of each trace to the space between any two adjacent traces is greater than 1. The thickness of the second copper layer in the thickness direction of the substrate is greater than the thickness of the second copper layer in a direction perpendicular to the thickness direction of the substrate.

Abstract: This application provides a method for training a semantic understanding model, including: obtaining a first training sample set; performing denoising processing on the first training sample set to form a corresponding second training sample set; processing the second training sample set by using a semantic understanding model, to determine initial parameters of the semantic understanding model; processing the second training sample set by using the semantic understanding model in response to the initial parameters of the semantic understanding model, to determine update parameters of the semantic understanding model; and iteratively updating a semantic representation layer network parameter and a task-related output layer network parameter of the semantic understanding model by using the second training sample set and according to the update parameters of the semantic understanding model.

Abstract: A magnetic memory device includes a core element, a free layer surrounding the core element, a barrier layer surrounding the free layer, and a reference layer surrounding the barrier layer. Two ends of the core element are electrically coupled to a first electrode and a second electrode, respectively. A direction of magnetization of the free layer is switchable between a first direction and a second direction under an influence of an electrical current flowing along the core element. The barrier layer includes an electrically insulating material. The reference layer is electrically coupled to a third electrode. A direction of magnetization of the reference layer remains along the first direction or the second direction.

Abstract: A physically unclonable function (PUF) includes a bit cell that includes a latch and a switch to selectively couple the latch to a supply voltage node. A first transmission gate couples a first bit line to a first internal node of the latch and a second transmission gate couples a second bit line to a second internal node of the latch. A digital to analog converter (DAC) circuit is selectively coupled to the first internal node through the first bit line and the first transmission gate and to the second internal node through the second bit line and the second transmission gate, to thereby precharge the latch before the first bit cell is read. The latch regenerates responsive to the switch being closed to connect the latch to the supply voltage node. The first and second bit lines are used to read the regenerated value of the latch.

Abstract: A phase-change memory (PCM) device includes a first electrode, a second electrode, a memory layer, and a heater. The memory layer includes a phase-change material and is electrically coupled between the first electrode and the second electrode. The heater is arranged near the memory layer and is configured to heat a programming region of the memory layer in response to an electric current that passes through the heater. The heater is coupled to a power source via an electric current path that does not pass through the memory layer.

Abstract: A magnetic memory device includes a core element, a free layer surrounding the core element, a barrier layer surrounding the free layer, and a reference layer surrounding the barrier layer. Two ends of the core element are electrically coupled to a first electrode and a second electrode, respectively. A direction of magnetization of the free layer is switchable between a first direction and a second direction under an influence of an electrical current flowing along the core element. The barrier layer includes an electrically insulating material. The reference layer is electrically coupled to a third electrode. A direction of magnetization of the reference layer remains along the first direction or the second direction.

Abstract: Implementations of the disclosure provide for video stream encoding system with live crop editing and recording. In one implementation, the method comprises receiving, by a camera device, an input video stream depicting an image. A first video stream and a second video stream are generated based on the input video stream. A crop instruction associated with the image is received based on user input. A region of interest in the first stream is determined based on the crop instruction. The first stream depicts a full field of view of the image associated with the input video stream. A cropped view presentation of the full field of view is generated to associate with the second stream in accordance with the region of interest. Thereupon, a portion of the cropped view presentation of the second stream is provided for display at a network device.

Abstract: In one embodiment, an apparatus includes a controller to control a voltage regulator. The controller may have a first comparator circuit to compare a first reference voltage to a feedback voltage. In turn, the first comparator circuit may include: a first comparator having a first input terminal to receive the feedback voltage and a second input terminal to receive the reference voltage and an output node to output an error signal based on the comparison; and a first pre-charge circuit coupled between the first input terminal and the output node configured to pre-charge a first portion of a compensation network to a pre-charge level. The first controller may further include a second comparator circuit coupled to the first comparator circuit compare the error signal to a ramp signal and to generate a first control output to control a power train of the voltage regulator in a first mode of operation.