Abstract: Embodiments of the present disclosure are directed to systems and methods for a closed-loop cochlear implant. The closed-loop cochlear implant can use at least one extra-cochlear electrode for monitoring auditory evoked potentials from the peripheral and central auditory pathway and stimulating to optimize speech processing. The closed-loop cochlear implant can further use at least one intra-cochlear electrode to stimulate the auditory nerve. Additionally, in some embodiments, the closed-loop cochlear implant can be used to monitor biosignals, such as EMG and ECG.

Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.

Abstract: Methods and devices for treating tinnitus in human or animal subjects wherein the subject is caused to perceive a tinnitus suppressing sound which fully or partially suppresses the subject's tinnitus. In some embodiments of this method, the subject selects a sound that he or she perceives to be the same as the tinnitus and that sound (or a similar sound that is complementary to the subject's perceived tinnitus) is then used as the tinnitus suppressing sound. In other embodiments, the tinnitus suppressing may be a sound that has previously been determined to suppress tinnitus in a substantial number of subjects.

Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.

Abstract: A method for calibrating a base station including a plurality of antennas is provided. First correction information is received from a system module, the correction information determined from first calibration of the base station Signals are received at a radio frequency module from at least one antenna of the base station Second correction information is determined on the basis of the received signals and the first correction information.

Abstract: Methods and devices for treating tinnitus in human or animal subjects wherein the subject is caused to perceive a tinnitus suppressing sound which fully or partially suppresses the subject's tinnitus. In some embodiments of this method, the subject selects a sound that he or she perceives to be the same as the tinnitus and that sound (or a similar sound that is complementary to the subject's perceived tinnitus) is then used as the tinnitus suppressing sound. In other embodiments, the tinnitus suppressing may be a sound that has previously been determined to suppress tinnitus in a substantial number of subjects.

Abstract: Cochlear implant performance is improved by extracting pitch information and encoding such pitch information into the processor of a cochlear implant. One embodiment of the invention is to explicitly extract the pitch and deliver it to the cochlear implant by co-varying the stimulated site and rate. Another embodiment of the invention is to implicitly encode the pitch information via a code book that serves as the carrier of stimulation in the cochlear implant.

Abstract: Methods, devices and systems for improving hearing and for treating hearing disorders, such as auditory neuropathies. A hearing enhancement system of this invention generally comprises; an amplitude modulation processor, a frequency high-pass processor, a frequency upward-shifting processor and a formant upward-shifting processor.

Abstract: Disclosed herein assay methods which comprise detecting the presence, absence or amount of at least one antibody which specifically binds a first biomarker or an epitope thereof and at least one second biomarker in a sample which comprises a single reaction step whereby both a first capture reagent for the antibody and a second capture reagent for the second biomarker are together contacted with the sample, and detecting the presence, absence or amount of the antibody, and detecting the presence, absence or amount of the second biomarker. Also disclosed are assay methods for prostate cancer.

Abstract: A transformer module includes at least one first casing, at least one second casing and at least one transformer. The first casing has a first receptacle. A protrusion structure is formed on an inner wall of the first receptacle. The second casing is accommodated within the first receptacle. The second casing includes plural winding terminals and a second receptacle. An angle of at least one outer-corner of the second casing is non-right angle so that the protrusion structure and the outer-corner define foolproof structures for limiting the install direction of the second case. The transformer is accommodated within the second receptacle. The transformer includes a magnetic core and at least one coil wound on the magnetic core. Both terminals of the coil are connected to respective winding terminals.

Abstract: Disclosed are methods for obtaining at least one epitope suitable for detecting the presence of an antibody against a tumor associated antigen of a cancer in a sample. Kits, assays, and substrates employing the epitopes of the present invention are disclosed. Also disclosed are epitopes of NY-ESO-1 and XAGE-1b and methods of using thereof.

Abstract: Methods and devices for treating tinnitus in human or animal subjects wherein the subject is caused to perceive a tinnitus suppressing sound which fully or partially suppresses the subject's tinnitus. In some embodiments of this method, the subject selects a sound that he or she perceives to be the same as the tinnitus and that sound (or a similar sound that is complementary to the subject's perceived tinnitus) is then used as the tinnitus suppressing sound. In other embodiments, the tinnitus suppressing may be a sound that has previously been determined to suppress tinnitus in a substantial number of subjects.

Abstract: A hot-melt pole is provided. The hot-melt pole comprises a first end and a second end opposite to the first end. The second end defines a guide hole. the guide hole is surrounded by a melting wall. A hot-melt method using the hot-melt pole is also provided.

Abstract: For generating a 3D geometric model (44) and/or a definition of the 3D geometric model from a single digital image of a building facade (4), a facade structure is detected from the digital image by dividing the facade (4) along horizontal lines into horizontal layers representative of floors (41), and by dividing the horizontal layers along vertical lines into tiles (42). The tiles (42) are further subdivided into a hierarchy of rectangular image regions (43). 3D architectural objects (45) corresponding to the image regions (43) are determined in an architectural element library. The 3D geometric model (44) or the definition of the 3D geometric model is generated based on the facade structure, the hierarchy and the 3D architectural objects (45). The library-based generation of the 3D geometric model makes it possible to enhance simple textured building models constructed from aerial images and/or ground-based photographs.

Abstract: The disclosure relates to jointly transmitting and processing analog-digital information using Inaudible Synchronous Online User-optimized Processing (iSOUP), wherein digital and analog information can be transmitted via one connection. iSOUP may be implemented in real-time MP3 anti-piracy, customized MP3 songs, Internet customized medical devices, Internet customized consumer electronics, Internet controlled psychoacoustic and physiological tests, tinnitus treatment devices, anti-piracy MP3 players, assistive listening MP3 players, healthcare sensor networks, Bluetooth sensors, audio-visual hearing aids (HAs) and cochlear implants (CIs), audio-touch HAs and CIs, Bluetooth HAs and CIs, automated fitting of HAs and CIs.

Abstract: Disclosed are methods for obtaining at least one epitope suitable for detecting the presence of an antibody against a tumor associated antigen of a cancer in a sample. Kits, assays, and substrates employing the epitopes of the present invention are disclosed. Also disclosed are epitopes of NY-ESO-1 and XAGE-1b and methods of using thereof.

Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.

Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.

Abstract: Methods, devices and systems for improving hearing and for treating hearing disorders, such as auditory neuropathies. A hearing enhancement system of this invention generally comprises; an amplitude modulation processor, a frequency high-pass processor, a frequency upward-shifting processor and a formant upward-shifting processor.

Abstract: A programmable cochlear implant system utilizes multiple-resolution current sources and flexible data-encoding scheme for transcutaneous transmission. In certain embodiments, the number of current sources may be equal to or greater than 2, but equal or less than N?1, where N is the number of electrodes. The multi-resolution current source may introduce offset currents to achieve perceptually-based multiple resolutions with high resolution at low amplitudes and low resolution at high amplitudes. The flexible data-encoding scheme may allow arbitrary waveforms in terms of phase polarity, phase duration, pseudo-analog-waveform, while producing high-rate and high-temporal-precision stimulation. In one embodiment, a 2-current-source system may support simultaneous and non-simultaneous stimulation as well as monopolar, bipolar, pseudo-tripolar, and tripolar electrode configurations.