Patents by Inventor Gaolian XU

Gaolian XU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid amplification blocker for detecting low-abundance mutation sequence and application thereof
    Patent number: 11834707
    Abstract: A nucleic acid amplification blocker for detecting a low-abundance mutation sequence and an application thereof in detecting a low-abundance mutation sequence are provided. The nucleic acid amplification blocker is an oligonucleotide modified by locked nucleic acid (LNA), and the matching region of the nucleic acid amplification blocker is located between amplified sequences. The nucleic acid amplification blocker is completely complementary to wild-type gene sequence, and contains at least one mismatch with mutant sequence. The nucleic acid amplification blocker has a great difference in affinity with mutant nucleic acid sequence/wild-type nucleic acid sequence, so as to achieve the purpose of highly selective amplification/enrichment of mutant sequence in samples. The nucleic acid amplification blocker has more significant detection effect on deletion mutation and insertion mutation.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: December 5, 2023
    Assignee: SHANGHAI MAG-GENE NANOTECH CO., LTD.
    Inventors: Hong Xu, Hao Yang, Gaolian Xu, Hongchen Gu
  • NUCLEIC ACID AMPLIFICATION BLOCKING AGENT FOR DETECTING LOW-ABUNDANCE MUTATION SEQUENCE AND USE THEREOF
    Publication number: 20220025452
    Abstract: A nucleic acid amplification blocker for detecting a low-abundance mutation sequence and an application thereof in detecting a low-abundance mutation sequence are provided. The nucleic acid amplification blocker is an oligonucleotide modified by locked nucleic acid (LNA), and the matching region of the nucleic acid amplification blocker is located between amplified sequences. The nucleic acid amplification blocker is completely complementary to wild-type gene sequence, and contains at least one mismatch with mutant sequence. The nucleic acid amplification blocker has a great difference in affinity with mutant nucleic acid sequence/wild-type nucleic acid sequence, so as to achieve the purpose of highly selective amplification/enrichment of mutant sequence in samples. The nucleic acid amplification blocker has more significant detection effect on deletion mutation and insertion mutation.
    Type: Application
    Filed: December 11, 2019
    Publication date: January 27, 2022
    Applicant: SHANGHAI MAG-GENE NANOTECH CO., LTD.
    Inventors: Hong XU, Hao YANG, Gaolian XU, Hongchen GU