Patents by Inventor Gareth M Davies
Gareth M Davies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11976611Abstract: A gas turbine engine for an aircraft comprises, in axial flow sequence, a compressor module, a combustor module, and a turbine module, with a first electric machine being rotationally connected to the turbine module. The first electrical machine is configured to generate a maximum electrical power PEM1 (W), and the gas turbine engine is configured to generate a maximum dry thrust T (N); and a ratio S of: S = ( Maximum ? Electrical ? Power ? Generated = P E ? M ? 1 ) ( Maximum ? Dry ? Thrust = T ) is in a range of between 2.0 and 10.0.Type: GrantFiled: September 8, 2022Date of Patent: May 7, 2024Assignee: ROLLS-ROYCE plcInventors: Paul R Davies, Gareth E Moore, Stephen M Husband, David R Trainer, David P Scothern, Luke George
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Patent number: 6441012Abstract: Compound of formula (I) wherein: A is a bicyclic heteroaryl, optionally substituted with one or more substituents; B is linker group connecting group A to group D and comprising a 3 or 4 atom linker where each atom is independently selected from carbon, oxygen, nitrogen and sulphur and is optionally subsituted with one or more C1-6 alkyl groups or two of such adjacent alkyl substituents may form a ring; C is aryl or a mono or bicyclic heteroaryl, each of which can be optionally substituted; D is an aryl or heteroaryl, both of which are optionally substituted R1 is hydrogen, C1-5 alkyl, C1-3 alkanoyl or C1-3 alkoxycarbonyl; R2 to R5 are each independently selected from hydrogen, C1-6 alkyl, aryl and heteroaryl containing up to 2 heteroatoms chosen from oxygen, sulphur and nitrogen, the aryl and heteroaryl optionally substituted with C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 alkanoyl, C1-6 alkylamino, C1-4alkylC1-6alkyoxyl, C1-6alkylaminoC1-6alkyl, nitro, cyano, halogeno, triflType: GrantFiled: January 23, 2001Date of Patent: August 27, 2002Assignee: AstraZeneca ABInventors: David R Brittain, Craig Johnstone, Michael S Large, Gareth M Davies
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Patent number: 5527791Abstract: The present invention provides a compound of the formula: ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:A is a group of the formula (IA) or (IB): ##STR2## R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 and R.sup.4 are the same or different and are a variety of substituents X is alkanediyl containing 1-6 carbon atoms optionally interrupted by O, S(O).sub.x (wherein x is zero, one or two), --CONR.sup.5 -- or --NR.sup.5 -- or wherein R.sup.5 is hydrogen or C.sub.1-4 alkyl;or X is alkenediyl containing 1-6 carbon atoms optionally interrupted by O, S(O).sub.x or --NR.sup.5 --.Type: GrantFiled: September 21, 1993Date of Patent: June 18, 1996Assignee: Zeneca LimitedInventors: Michael J. Betts, Gareth M. Davies, Frederic H. Jung
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Patent number: 5478820Abstract: The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 is hydrogen or C.sub.1-4 alkyl;R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4 alkyl, nitro, hydroxy, carboxy, C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, C.sub.1-4 alkylaminosulphonyl, di-C.sub.1-4 alkylaminosulphonyl, carbamoyl, C.sub.1-4 alkylcarbamoyl, di-C.sub.1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkanoyl(N-C.sub.1-4 alkyl)amino, C.sub.1-4 alkanesulphonamido and C.sub.1-4 alkylS(O).sub.n -- wherein n is zero, one or two:with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the --NR.sup.2 --.Type: GrantFiled: October 4, 1993Date of Patent: December 26, 1995Assignee: Zeneca Ltd.Inventors: Michael J. Betts, Gareth M. Davies, Michael L. Swain
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Patent number: 5214165Abstract: 6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.Type: GrantFiled: August 24, 1992Date of Patent: May 25, 1993Assignee: Imperial Chemical Industries PLCInventors: James K. Sutherland, William J. Watkins, George A. Snow, Gareth M. Davies
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Patent number: 5164382Abstract: 6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal, and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.Type: GrantFiled: April 17, 1990Date of Patent: November 17, 1992Assignee: Imperial Chemical Industries plcInventors: James K. Sutherland, William J. Watkins, George A. Snow, Gareth M. Davies
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Patent number: 5149803Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula:--CH.sub.2 NR.sup.1 --Y--A--Z--Qare described, wherein R.sup.1 is hydrogen or certain optionally substituted alkyl groups; Y is --CO-- or --SO.sub.2 --; A is optionally substituted phenylene or heterocyclylene; Z is a linking group and Q is a catechol or related ring system. Processes for their preparation and use are described.Type: GrantFiled: July 18, 1991Date of Patent: September 22, 1992Assignees: Imperial Chemical Industries PLC, ICI PharmaInventors: Gareth M. Davies, Colin J. Strawson, Jean J. Lohmann
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Patent number: 5055462Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula:--CH.sub.2 NR.sup.1 --Y--A--Z--Qare described, wherein R.sup.1 is hydrogen or certain optionally substituted alkyl groups; Y is --CO-- or --SO.sub.2 --; A is optionally substituted phenylene or heterocyclylene; Z is a linking group and Q is a catechol or related ring system. Processes for their preparation and use are described.Type: GrantFiled: May 10, 1989Date of Patent: October 8, 1991Assignees: Imperial Chemical Industries plc, ICI PharmaInventors: Gareth M. Davies, Colin J. Strawson, Jean J. Lohmann
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Patent number: 4504478Abstract: An antibacterial cephalosporin derivative of the formula I: ##STR1## in which X.sup.1 is sulphinyl; R.sup.1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R.sup.2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R.sup.3 is hydrogen, 1-6C alkoxy or 1-6C alkylthio; X.sup.2 is nitrogen or a radical N.sup..sym. R.sup.5 ; R.sup.4 and R.sup.5 are a variety of radicals described in the specification; --A-- is of the formula II or III: ##STR2## in which R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are a variety of substituents described in the specification; and the pharmaceutically-acceptable acid- and base-addition salts thereof. Pharmaceutical compositions and manufacturing processes are also described.Type: GrantFiled: September 7, 1982Date of Patent: March 12, 1985Assignees: Imperial Chemical Industries PLC, ICI PharmaInventors: Frederic H. Jung, Gareth M. Davies
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Patent number: 4492692Abstract: A cephalosporin derivative of the formula: ##STR1## in which R.sup.0 is a hydrogen atom or a methyl radical, R.sup.1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R.sup.2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R.sup.3 is a hydrogen atom or a 1-6C alkoxy or 1-6C alkylthio radical; X.sup.1 is a sulphur or oxygen atom, a CH.sub.2 radical or a radical of the formula NR.sup.7 in which R.sup.7 is a hydrogen atom, a 1-6C alkyl, formyl or benzyl radical; X.sup.2 is a nitrogen atom or a radical of the formula N.sup..sym. -R.sup.7 ; R.sup.4 and R.sup.7, and R.sup.5 and R.sup.6 are a variety of substituents which are described in the specification; and the pharmaceutically-acceptable acid- or base-addition salts thereof. Pharmaceutical compositions, manufacturing processes and intermediates are also described.Type: GrantFiled: December 22, 1981Date of Patent: January 8, 1985Assignees: Imperial Chemical Industries PLC, ICI PharmaInventors: Frederic H. Jung, Gareth M. Davies
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Patent number: 4490382Abstract: A penicillin derivative of the formula I: ##STR1## in which R.sup.1 is any one of the C-3 substituents from antibacterially-active penicillins known in the art;X is a nitrogen atom or a radical of the formula N.sup..sym. --R.sup.3 ;R.sup.2 and R.sup.3, which may be the same or different, are hydrogen atoms or 1-6C alkyl, 1-6C alkanoyl, hydroxy, 1-6C alkoxy, amino, 1-6C alkanoylamino, 1-6C alkylamino, 1-6C aminoalkyl, 1-6C hydroxyalkyl, 2-6C carboxyalkyl, 2-6C alkenyl, 3-6C alkoxyalkyl, 3-8C alkoxycarbonylalkyl, furylmethyl, phenyl or 7-11C phenylalkyl radicals, in the latter two of which the phenyl ring is optionally substituted by a halogen atom or by a methyl, methoxy, nitro, hydroxy, amino, carboxy or methoxy-carbonyl radical;A< is a radical of the formula II or III: ##STR2## in which R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are as described in the specification; and the pharmaceutically-acceptable acid- or base-addition salts thereof.Type: GrantFiled: December 22, 1981Date of Patent: December 25, 1984Assignees: Imperial Chemical Industries PLC, ICI PharmaInventors: Frederic H. Jung, Gareth M. Davies
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Patent number: 4486426Abstract: An antibacterial cephalosporin derivative of the formula I: ##STR1## in which X.sup.1 is sulphur, oxygen, sulphinyl or sulphonyl; R.sup.1 is a variety of radicals defined in the specification; R.sup.2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R.sup.3 is hydrogen or methoxy; X.sup.2 is nitrogen or a radical N.sup..sym. R.sup.8 ; R.sup.4 and R.sup.8 are a variety of radicals described in the specification; --A-- is of the formula V or VI: ##STR2## in which R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 are a variety of substituents described in the specification; and the pharmaceutically-acceptable acid- and base-addition salts thereof. Pharmaceutical compositions and manufacturing processes are also described.Type: GrantFiled: July 19, 1982Date of Patent: December 4, 1984Assignee: Imperial Chemical Industries PLCInventors: Frederich Jung, Gareth M. Davies