Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

Abstract: The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention are pentacyclic acid triterpenes. Methods for controlling biofilms and for controlling and/or preventing bacterial infections are also disclosed.

Abstract: The present invention provides a method for reducing or preventing the invasion of a bacterium into a tissue comprising modulating the expression of a cysB gene in the bacterium. The present invention further provides an in vivo method for reducing or preventing the formation of a biofilm in a tissue comprising modulating expression of a cysB gene in a cell capable of biofilm formation. The present invention also provides a method for controlling or preventing a chronic bacterial infection in a subject in need thereof comprising modulating the expression of a cysB gene in a bacterium that causes the chronic bacterial infection.

Abstract: The present invention provides methods for preventing, reducing, inhibiting or removing bacterial biofilm. The present invention also provides methods for controlling acne and chronic bacterial infections. The present invention further provides a method for identifying agents that prevent, reduce, inhibit or remove bacterial biofilm.

Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

Abstract: The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.

Abstract: The present invention discloses compounds, compositions, and methods of using such compounds and compositions to inhibit, reduce, prevent, and remove biofilms. The invention further relates to methods of inhibiting biofilms on various substrates, such as medical devices.

Abstract: The invention provides a chemical compound library containing a collection of chromatographic fractions purified from biological sources suitable for high-throughput screening for biological activity, wherein: (a) the chromatographic fractions contain primarily from about 1 microgram to 100 micrograms of primarily one to five chemical compounds; (b) the compounds have log P of greater than-1 and less than 5 and molecular weights less than 3,000 Daltons; (c) the library can include chemical compounds produced from at least fifty different biological sources; and (d) the library can contain at least about 200 different chemical compounds from each different biological source.

Abstract: Detection of the flow of a fluid, and also measurement of the flow of a fluid, is provided by feeding the fluid flow through a cylindrical chamber to form a cyclonic circulation of the fluid in the chamber. A movable member is moved by the fluid flow. As one example a ball rotates around the inside of the chamber and the passage of the ball detected, at a particular position. An alternative is an annular member also rotated. There can be an optical detection or electronic detection. Output signal can be generated by the movement. Such signals can be processed to give flow rates. The chamber is positioned in a by-pass flow line, with the flow rate of the by-pass related to the total flow.

Abstract: Detection of the flow of a fluid, and also measurement of the flow of a fluid, is provided by feeding the fluid flow through a cylindrical chamber to form a cyclonic circulation of the fluid in the chamber. A movable member is moved by the fluid flow. As one example a ball rotates around the inside of the chamber and the passage of the ball detected, at a particular position. An alternative is an annular member also rotated. There can be an optical detection or electronic detection. Output signal can be generated by the movement. Such signals can be processed to give flow rates.

Abstract: This invention relates to a sight targeting and range finding device which permits the bow to be aligned properly to a destined target. The bow sight-range finder device can be programmed by the user to select the proper targeting marker for a given distance and also allow selection of range finder markers that can be programmed to be used in conjunction with the targeting markers. When the range finder is used by the archer, the site targeting markers are automatically positioned. The bow sight includes a control which provides interface between the bow sight electronic circuitry and the archers fingers on the hand holding the bow.