Patents by Inventor Gary A. Flynn

Gary A. Flynn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
    Publication number: 20020095035
    Abstract: The present invention provides a method of inhibiting matrix metallo-proteinases (MMPs) in a patient in need thereof comprising administering to the patient an effective matrix metalloproteinase inhibiting amount of the N-carboxymethyl substituted benzolactams of formula (1): 1
    Type: Application
    Filed: February 20, 2002
    Publication date: July 18, 2002
    Inventors: Alan M. Warshawsky, Michael J. Janusz, Gary A. Flynn
  • Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
    Patent number: 6365572
    Abstract: Low molecular weight peptide derivatives which are able to act as inhibitors of the interaction between laminin and nidogen (laminin/nidogen interaction), a process for their preparation, pharmaceutical compositions prepared therefrom and their use for preparing pharmaceuticals and for identifying inhibitors of the laminin/nidogen interaction.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: April 2, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans Ulrich Stilz, Martin Gerl, Gary A. Flynn, Magda Stankova, Robert A. Binnie
  • 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
    Publication number: 20020037859
    Abstract: The present invention provides novel 3-substituted pyrrolidines of the formula 1
    Type: Application
    Filed: March 23, 2001
    Publication date: March 28, 2002
    Inventor: Gary A. Flynn
  • Substituted benzimidazoles
    Patent number: 6358978
    Abstract: Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF&kgr;B is involved.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: March 19, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, William Jerome Bock, Jr., Armin Walser, Gary A. Flynn, Jörg Habermann, Gerhard Jähne
  • Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
    Patent number: 6013645
    Abstract: The present invention relates certain mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholestrolemia.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: January 11, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, John F. French, Richard C. Dage
  • Mercaptoacetylamino 1,3,4,5-tetrahydro-benzo(C)azepin-2-one disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5880119
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5872251
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: February 16, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, Thomas D. Bannister
  • Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5859252
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: January 12, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, Thomas D. Bannister, Michael J. Genin, Douglas W. Beight
  • Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5849908
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: December 15, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gary A. Flynn, Michael J. Genin, Douglas W. Beight
  • Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5750521
    Abstract: The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: May 12, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Shujaath Mehdi, Alan M. Warshawsky, John F. French, John H. Kehne
  • Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5734049
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: March 31, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, Michael J. Genin, Douglas W. Beight
  • Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5731306
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: March 24, 1998
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5641880
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: June 24, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, Thomas D. Bannister
  • Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5635502
    Abstract: The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE.These mercaptoacetylamide bicyclic lactam derivatives can be described by the following formula: ##STR1## wherein R is hydrogen, a C.sub.1 -C.sub.4 alkyl, an Ar--Y--group, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 or diphenylmethyl;R.sub.1 is hydrogen, acetyl, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3, benzoyl or a group of the formula ##STR2## R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, --CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 or an Ar--Y--group;A is --CH.sub.2 --, --O--, or --S--;B is --S--or --O--; andpharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: June 3, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventor: Gary A. Flynn
  • 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5629309
    Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: May 13, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Hypotriglyceridemic aminoacetylmercapto derivatives
    Patent number: 5624921
    Abstract: The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: August 9, 1995
    Date of Patent: April 29, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, John F. French, Richard C. Dage
  • Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
    Patent number: 5604221
    Abstract: The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: February 18, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John H. Kehne
  • Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives
    Patent number: 5602122
    Abstract: The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: February 11, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, John F. French, Richard C. Dage
  • 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5591739
    Abstract: The present invention relates to novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: January 7, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Gary A. Flynn
  • 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5567814
    Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: October 22, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne