Abstract: The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.

Abstract: Systems and methods for tracking eye movement includes directing an incident light beam onto each facet of a pyramidal prism to produce a plurality of beams that form a plurality of light spots, at least two of the light spots having different diameters. The prism is translatable to effect a change in spacing of the light spots. Intensities of light reflected from the light spots is used to retain the light spots upon a pupil/iris boundary. A relative intensity of the spots indicates a change in pupil size. A second light spot positioned on a predetermined eye sector can also be used to calculate a pupil characteristic and an environmental effect on light received from the eye.

Abstract: Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

Abstract: An orientation method for corrective eye surgery that registers pairs of eye images taken at different times and with the patient in different positions includes retrieving reference digital image data on an eye of the patient, including image data on an extracorneal eye feature. Real-time image data are collected that include image data on the extracorneal eye feature. A combined image is displayed of a superposition of the data sets, and a determination is made as to whether the combined image indicates an adequate registration between them based upon the extracorneal eye feature data in the two data sets. If the registration is not adequate, one of the data sets is manipulated until an adequate registration is achieved. A system is directed to apparatus and software for orienting a corrective program for eye surgery.

Abstract: Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

Abstract: Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

Abstract: The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.

Abstract: CTLA4-immunoglobulin fusion proteins having modified immunoglobulin constant region-mediated effector functions, and nucleic acids encoding the fusion proteins, are described. The CTLA4-immunoglobulin fusion proteins comprise two components: a first peptide having a CTLA4 activity and a second peptide comprising an immunoglobulin constant region which is modified to reduce at least one constant region-mediated biological effector function relative to a CTLA4-IgG1 fusion protein. The nucleic acids of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins in a variety of hosts, particularly eukaryotic cells. The CTLA4-immunoglobulin fusion proteins described herein can be administered to a subject to inhibit an interaction between a CTLA4 ligand (e.g., B7-1 and/or B7-2) on an antigen presenting cell and a receptor for the CTLA4 ligand (e.g.

Abstract: A system and method for tracking ocular changes during a surgical procedure include directing an eye-safe optical beam toward an undilated, unparalyzed eye. A reflected optical beam is detected, and measurements are performed based upon data contained in the reflected optical beam of at least one geometric parameter of the eye at a predetermined frequency, and from them is calculated a change in the at least one geometric parameter. The calculated change is used to dynamically adjust the directing of laser beam shots during the surgery.

Abstract: Tumor cells modified to express one or more T cell costimulatory molecules are disclosed. Preferred costimulatory molecules are B7-2 and B7-3. The tumor cells of the invention can be modified by transfection with nucleic acid encoding B7-2 and/or B7-3, by using an agent which induces or increases expression of B7-2 and/or B7-3 on the tumor cell or by coupling B7-2 and/or B7-3 to the tumor cell. Tumor cells modified to express B7-2 and/or B7-3 can be further modified to express B7. Tumor cells further modified to express MHC class I and/or class II molecules or in which expression of an MHC associated protein, the invariant chain, is inhibited are also disclosed. The modified tumor cells of the invention can be used in methods for treating a patient with a tumor, preventing or inhibiting metastatic spread of a tumor or preventing or inhibiting recurrence of a tumor.

Abstract: A surgical theater apparatus for suspending from a ceiling structural member of a hospital includes a central hub mountable to the ceiling structural member to rotate about a rotation axis. The hub has a pivot axis spaced apart from the rotation axis. First and second devices, such as surgical lights, a cameras, and monitors, are mounted to a first end of a first device arm and a first end of a second device arm, respectively. A second end of the first device arm is mounted to the hub for movement about the rotation axis and about the pivot axis. A second end of the second device arm is mounted to the hub for movement about the rotation axis. The pivot axis and the rotation axis are parallel.

Abstract: Exercise machines and methods of exercising which utilize a side-to-side stepping motion to exercise the lower extremities.

Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

Abstract: A surgical light apparatus includes a hub assembly configured to be attached to a ceiling, and an arm coupled for pivotal movement about the hub assembly. In certain embodiments, a monitor is mounted on a monitor mount attached to the arm. The monitor mount includes a handle on which a first actuator is mounted. A video input controller is electrically coupled to the monitor. The video input controller includes a first channel input having a video coupling for attachment to a first video input device providing a first video feed, a second channel input having a video coupling for attachment to a second video device providing a second video feed, and a channel controller coupled to the monitor, the first channel input, and the second channel input. The channel controller is coupled to the first actuator and is configured to select a video feed to the monitor in response to actuation of the first actuator. In certain embodiments, a camera mount is mounted to the arm.

Abstract: A surgical theater apparatus for suspending from a ceiling structural member of a hospital includes a central hub mountable to the ceiling structural member to rotate about a rotation axis. The hub has a pivot axis spaced apart from the rotation axis. First and second devices, such as surgical lights, a cameras, and monitors, are mounted to a first end of a first device arm and a first end of a second device arm, respectively. A second end of the first device arm is mounted to the hub for movement about the rotation axis and about the pivot axis. A second end of the second device arm is mounted to the hub for movement about the rotation axis. The pivot axis and the rotation axis are parallel.

Abstract: A surgical theater apparatus for suspending from a ceiling structural member of a hospital includes a central hub mountable to the ceiling structural member to rotate about a rotation axis. The hub has a pivot axis spaced apart from the rotation axis. First and second devices, such as surgical lights, a cameras, and monitors, are mounted to a first end of a first device arm and a first end of a second device arm, respectively. A second end of the first device arm is mounted to the hub for movement about the rotation axis and about the pivot axis. A second end of the second device arm is mounted to the hub for movement about the rotation axis. The pivot axis and the rotation axis are parallel.

Abstract: A surgical theater apparatus for suspending from a ceiling structural member of a hospital includes a central hub mountable to the ceiling structural member to rotate about a rotation axis. The hub has a pivot axis spaced apart from the rotation axis. First and second devices, such as surgical lights, a cameras, and monitors, are mounted to a first end of a first device arm and a first end of a second device arm, respectively. A second end of the first device arm is mounted to the hub for movement about the rotation axis and about the pivot axis. A second end of the second device arm is mounted to the hub for movement about the rotation axis. The pivot axis and the rotation axis are parallel.

Abstract: A surgical light apparatus includes a hub assembly configured to be attached to a ceiling, and an arm coupled for pivotal movement about the hub assembly. In certain embodiments, a monitor is mounted on a monitor mount attached to the arm. The monitor mount includes a handle on which a first actuator is mounted. A video input controller is electrically coupled to the monitor. The video input controller includes a first channel input having a video coupling for attachment to a first video input device providing a first video feed, a second channel input having a video coupling for attachment to a second video device providing a second video feed, and a channel controller coupled to the monitor, the first channel input, and the second channel input. The channel controller is coupled to the first actuator and is configured to select a video feed to the monitor in response to actuation of the first actuator. In certain embodiments, a camera mount is mounted to the arm.