Patents by Inventor Gary A. Peltz
Gary A. Peltz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240053335Abstract: Provided are methods of analyzing a capillary microsample obtained from a subject. In certain embodiments, the methods comprise assessing a test mixture for one or more capillary microsample analytes, wherein the test mixture comprises the capillary microsample diluted into a stabilizing buffer comprising isopropanol, ethanol, methanol, or a combination thereof. Such methods further comprise analyzing capillary microsample nucleic acids purified from the test mixture. According to some embodiments, analyzing the capillary microsample nucleic acids comprises genotyping the subject. Methods of determining one or more alleles of a subject are also provided, as are kits that find use in practicing the methods of the present disclosure.Type: ApplicationFiled: December 20, 2021Publication date: February 15, 2024Inventors: Gary Peltz, Feng Hu
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Publication number: 20220168359Abstract: Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.Type: ApplicationFiled: February 15, 2022Publication date: June 2, 2022Inventors: Gary Peltz, Dan Xu
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Patent number: 11291691Abstract: Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.Type: GrantFiled: May 8, 2018Date of Patent: April 5, 2022Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Gary Peltz, Dan Xu
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Publication number: 20210086176Abstract: Methods, kits and systems described herein provide collecting, preparing, processing and/or analyzing a clinical sample, such as a blood. The methods, kits and systems may use a biocompatible solution comprising water and a stabilizing solvent, such as isopropanol, for accurate testing of the presence and/or amount of dmg, nutrient, or metabolite.Type: ApplicationFiled: October 31, 2018Publication date: March 25, 2021Inventors: Gary Peltz, Manhong Wu
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Publication number: 20190083545Abstract: Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.Type: ApplicationFiled: May 8, 2018Publication date: March 21, 2019Inventors: Gary Peltz, Dan Xu
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Patent number: 10004767Abstract: Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.Type: GrantFiled: September 17, 2014Date of Patent: June 26, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Gary Peltz, Dan Xu
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Publication number: 20160256499Abstract: Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.Type: ApplicationFiled: September 17, 2014Publication date: September 8, 2016Inventors: Gary Peltz, Dan Xu
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Patent number: 9226918Abstract: This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.Type: GrantFiled: December 4, 2009Date of Patent: January 5, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Gary Peltz, David Clark, Lawrence Chu
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Publication number: 20140236166Abstract: Methods for prognosis and diagnosis of pancreatic cysts are disclosed. In particular, the invention relates to the use of biomarkers from pancreatic cyst fluid to aid in the diagnosis, prognosis, and treatment of pancreatic cysts. More specifically, differential expression of certain metabolites, including glucose and kynurenine, and the protein, amphiregulin, is used to distinguish benign, pre-malignant, and malignant pancreatic cysts.Type: ApplicationFiled: February 14, 2014Publication date: August 21, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Walter G. Park, Pankaj J. Pasricha, Gary Peltz, Anson Lowe
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Publication number: 20100144754Abstract: This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.Type: ApplicationFiled: December 4, 2009Publication date: June 10, 2010Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Gary PELTZ, David CLARK, Lawrence CHU
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Publication number: 20060204965Abstract: Methods and reagents for determining sequence variants present at the FRZB locus, which facilitate identifying individuals at risk for obesity and/or osteoporosis, are provided. In particular, methods for detecting an individual's risk for obesity and/or osteoporosis by detecting at least one polymorphism (e.g., at least one single nucleotide polymorphism) in the FRZB gene in a nucleic acid sample from the individual are provided. Related kits, arrays and systems are also described.Type: ApplicationFiled: April 20, 2004Publication date: September 14, 2006Inventors: Russell Higuchi, Gary Peltz, Bonnie Fijal, Sunhee Ro, Jia Li
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Publication number: 20060110768Abstract: Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.Type: ApplicationFiled: November 23, 2005Publication date: May 25, 2006Inventors: John Allard, Dee Aud, Guochun Liao, Gary Peltz
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Publication number: 20060079488Abstract: Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.Type: ApplicationFiled: November 23, 2005Publication date: April 13, 2006Inventors: John Allard, Robert Klein, Gary Peltz
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Publication number: 20060058969Abstract: Computer systems, computer program products and methods for processing an input nucleic acid chromatogram having a plurality of substantially simultaneous traces. Each trace in the plurality of traces has a plurality of datapoints. Each respective datapoint in each of the plurality of datapoints represents a signal amplitude at a position in the trace corresponding to the respective datapoint. A first peak is identified in a first trace that is substantially overlapping a second peak in a second trace in the plurality of traces. The first peak is outputted to a first output homozygous representation and the second peak is outputted to a second output homozygous representation. The first output homozygous representation is a first homozygous sequence representation or a first homozygous nucleic acid chromatogram corresponding to the input nucleic acid chromatogram.Type: ApplicationFiled: September 15, 2004Publication date: March 16, 2006Inventors: Guochun Liao, Jonathan Usuka, Gary Peltz
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Publication number: 20060051780Abstract: The present invention relates to polymorphic Plasminogen genes and polypeptides. In particular, the present invention provides assays for the detection of Plasminogen polymorphisms and mutations associated with disease states and provides screening assays for the identification and use of compounds that alter Plasminogen activity and/or biological pathways involving Plasminogen.Type: ApplicationFiled: April 18, 2005Publication date: March 9, 2006Applicants: Duke University, Roche Palo Alto LLCInventors: Aimee Zaas, David Schwartz, Gary Peltz
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Publication number: 20060014187Abstract: The current invention is based on the discovery that the Prol2Ala and VN102 single nucleotide polymorphisms in the PPAR?2 provides a method of determining a susceptibility to osteoporosis by detecting the presence of PPAR? of the alleles.Type: ApplicationFiled: June 28, 2005Publication date: January 19, 2006Applicant: Roche Molecular Systems., Inc.Inventors: Jia Li, Russell Higuchi, Sunhee Ro, Gary Peltz
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Patent number: 6294347Abstract: Soluble and membrane-bound forms of human Fc&ggr;RIII are provided, together with nucleic acids capable of encoding the same. Soluble Fc&ggr;RIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic prupura. Cells expressing membrane-bound Fc&ggr;RIIIs are useful components in assays for serum immune complexes.Type: GrantFiled: January 19, 1999Date of Patent: September 25, 2001Assignee: Applied Research Systems ARS Holding N.V.Inventors: Gary A. Peltz, Kevin W. Moore
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Patent number: 6034137Abstract: This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.Type: GrantFiled: October 20, 1997Date of Patent: March 7, 2000Assignee: Syntex (U.S.A.) Inc.Inventors: Paula N. Belloni, Donald R. Hirschfeld, John O. Link, John J. Nestor, Jr., Gary A. Peltz
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Patent number: 5976831Abstract: Soluble and membrane-bound forms of human Fc.gamma.RIII are provided, together with nucleic acids capable of encoding the same. Soluble Fc.gamma.RIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound Fc.gamma.RIII are useful components in assays for serum immune complexes.Type: GrantFiled: April 5, 1995Date of Patent: November 2, 1999Assignee: Applied Research Systems ARS Holding, N.V.Inventors: Gary A. Peltz, Kevin W. Moore
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Patent number: 5767077Abstract: Soluble and membrane-bound forms of human FC.gamma.RIII are provided, together with nucleic acids capable of encoding the same. Soluble Fc.gamma.RIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound Fc.gamma.RIIIs are useful components in assays for serum immune complexes.Type: GrantFiled: June 7, 1995Date of Patent: June 16, 1998Assignee: Applied Research Systems ARS Holding N.V.Inventors: Gary A. Peltz, Kevin W. Moore