Patents by Inventor Gary A. Strobel

Gary A. Strobel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030049230
    Abstract: Isolates of Serratia marcescens such as Serratia marcescens MSU-97 and serratamolide are useful to protect plants from Oomycete pathogens.
    Type: Application
    Filed: May 15, 2002
    Publication date: March 13, 2003
    Inventors: Gary A. Strobel, Steven L. Morrison, Melanie Cassella
  • Publication number: 20020032308
    Abstract: Oocydin A is a mono-chlorinated lipophilic macrocyclic lactone that was isolated from a strain of Serratia marcescens that produces oocydin A in culture. Oocydin A has a molecular mass of 470, contains one atom of chlorine, a carboxyl group, and a tetrahydrofuran ring internal to a larger macrocyclic ring. Minimum inhibitory concentrations of circa 0.03 &mgr;g ml−1 were noted for oocydin A against phytopathogenic Oomycetes.
    Type: Application
    Filed: May 17, 2001
    Publication date: March 14, 2002
    Inventors: Gary A. Strobel, Jia Yao Li
  • Patent number: 6329193
    Abstract: Taxol is produced from taxol-producing micro-organisms. Methods of obtaining the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: December 11, 2001
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Gary Strobel, Andrea A. Stierle, Donald B. Stierle
  • Patent number: 6103875
    Abstract: The present invention is directed to a family of unique antimycotic lipopeptide compounds produced by Pseudomonas viridiflava. The lipopeptides are effective against both human and plant fungal pathogens, and are typically characterized by their ability to inhibit growth of Candida albicans. Representative lipopeptides of the invention have molecular weights of 1137, 1153, 1164 and 1181 daltons.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: August 15, 2000
    Assignee: Pharmagenesis, Inc.
    Inventors: Concepcion Martinez-Miller, Roger V. Miller, Gary A. Strobel
  • Patent number: 6013493
    Abstract: Taxol is produced from taxol-producing micro-organisms. Methods of obtain the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 11, 2000
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Andrea Stierle, Donald Stierle, Gary Strobel
  • Patent number: 5981264
    Abstract: An isolated substantially pure pseudomonas culture, exemplified by pseudomonas syringae MSU 16H (ATCC No. 67028), produces the substantially pure peptide pseudomycin which has broad spectrum anti-fungal characteristics.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: November 9, 1999
    Assignee: The Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5958741
    Abstract: Taxol is produced from taxol-producing microorganisms. Methods of obtaining he taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: September 28, 1999
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Andrea Stierle, Donald Stierle, Gary Strobel
  • Patent number: 5916783
    Abstract: Taxol is produced from taxol-producing microorganisms. Methods of obtaining he taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: June 29, 1999
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Andrea Stierle, Donald Stierle, Gary Strobel
  • Patent number: 5908759
    Abstract: Taxol is produced from taxol-producing microorganisms. Methods of obtaining he taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: June 1, 1999
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Andrea Stierle, Donald Stierle, Gary Strobel
  • Patent number: 5861302
    Abstract: Taxol is produced from taxol-producing micro-organisms. Methods of obtain the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: January 19, 1999
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Andrea Stierle, Donald Stierle, Gary Strobel
  • Patent number: 5837685
    Abstract: Peptide antimycotics, termed pseudomycins, display broad spectrum antibiotic activity, and in particular are highly effective, non-toxic antibiotics against fungal pathogens of human and animal disease. The peptide antimycotics (pseudomycins) may be used in the treatment of the fungal pathogen Candida albicans. Also disclosed is a method of purification and isolation, including characterization, of the pseudomycins.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: November 17, 1998
    Assignee: Research and Development Institute Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5648376
    Abstract: An immunosuppressant compound is produced having the structure: ##STR1## or a mirror image thereof, wherein X.sub.1 is 2,2-dimethylvinyl and X.sub.2 and X.sub.3 together are .dbd.CH.sub.2 ; or X.sub.1 is 2,2-dimethyloxiranyl, and X.sub.2 and X.sub.3 together are --0--CH.sub.2 --; or X.sub.1 is 1,2-dihydroxy-2-methyl-propyl, X.sub.2 is --CH.sub.2 OH, and X.sub.3 is OH; or X.sub.1 is 2-hydroxy-2-methylpropyl, X.sub.2 is H, and X.sub.3 is CH.sub.2 OH; or X.sub.1 is COOR, and X.sub.2 and X.sub.3 together are .dbd.O, where R is a lower alkyl, phenyl, or benzyl group; or X.sub.1 is 2-methylpropyl, X.sub.2 is H, and X.sub.3 is CH.sub.3. The compound can be produced by culturing Fusarium subglutinans f. sp. tripterygii ATCC 74358 isolated from the stems of Tripterygium wilfordii. A pharmaceutical composition for immunosuppression therapy is prepared containing the compound and a pharmaceutically acceptable vehicle.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: July 15, 1997
    Assignee: Pharmagenesis, Inc.
    Inventors: Gary A. Strobel, Nathan B. Pliam
  • Patent number: 5576298
    Abstract: Peptide antimycotics, termed pseudomycins, display broad spectrum antibiotic activity, and in particular are highly effective, non-toxic antibiotics against fungal pathogens of human and animal disease. The peptide antimycotics (pseudomycins) may be used in the treatment of the fungal pathogen Candida albicans. Also disclosed is a method of purification and isolation, including characterization, of the pseudomycins.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: November 19, 1996
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5451392
    Abstract: Taxol and radiolabelled taxol are produced from sterilized Yew trees by contacting sterilized Yew tree stock with a reactor solution comprising a reducing agent, an energy source, a buffer to maintain pH in the range of 6.5 to 7.5, a taxol precursor, and a steroid inhibitor. A radiolabelled precursor may be included in the reactor solution to produced radiolabelled taxol.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: September 19, 1995
    Assignee: The Research and Development Institute at Montana State University
    Inventors: Gary A. Strobel, Andrea A. Stierle
  • Patent number: 5445809
    Abstract: Taxol and radiolabelled taxol are produced from sterilized Yew trees by contacting sterilized Yew tree stock with a reactor solution comprising a taxol precursor under a reducing environment. The reactor solution may also contain a reducing agent, an energy source, a buffer to maintain pH in the range of 6.0 to 8.0, and a steroid inhibitor. A radiolabelled precursor may be included in the reactor solution to produced radiolabelled taxol.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: August 29, 1995
    Assignee: Research and Development Institute at Montana State University
    Inventors: Gary A. Strobel, Andrea A. Stierle
  • Patent number: 5322779
    Abstract: Taxol is produced from a taxol-producing microorganism Taxomyces andreanae BS 279.92. Radioactive taxol products and methods for use of the radioactive labelled taxol are described.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: June 21, 1994
    Assignee: The Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Andrea A. Stierle, Donald B. Stierle
  • Patent number: 4929270
    Abstract: A method of selectively inducing chlorosis on a knapweed plant while spar other plants comprises applying a knapweed phytotoxic amount of the L,L isomer of the cyclodipeptide of the invention to a field at a period in time prior, during or subsequent to the emergence of the plants; and allowing for the cyclodipeptide to remain in contact with the plants for a period of time effective to attain the phytotoxic effect.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: May 29, 1990
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: John H. Cardellina, II, Andrea C. Stierle, Gary A. Strobel
  • Patent number: 4588693
    Abstract: Beneficial growth of roots in dicotyledonous plants is achieved by genetic transformation with root-inducing A. rhizogenes, preferably the novel strain A. rhizogenes ATCC 39207. The A. rhizogenes not used to transform the plant is reduced to noninfective levels with A. radiobacter, preferably A. radiobacter K-84.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: May 13, 1986
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventor: Gary A. Strobel
  • Patent number: 4517008
    Abstract: A novel agriculturally useful composition that includes a seed treated with selected infectivity-cured Hr plasmid-bearing microorganism. Also provided are methods of enhancing root elongation, shoot elongation or root development of selected seeds. These methods include treating a selected seed with the infectivity-cured Hr plasmid-bearing microorganism. In addition, there is provided a method of inducing germination of grass seed that involves treating a grass seed such as Kentucky bluegrass seed with a selected infectivity-cured Hr plasmid-bearing microorganism. Furthermore, there is provided a method of promoting plant growth at a lower soil temperature than is common at the time of planting a seed of the plant. Additionally, there is disclosed an inoculant for increasing nodulation, root mass and shoot mass in a leguminous plant. The inoculant contains a Rhizobium microorganism and a selected infectivity-cured Hr plasmid-bearing microorganism.
    Type: Grant
    Filed: June 16, 1982
    Date of Patent: May 14, 1985
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Andrea H. Gavlak, Jesse M. Jaynes
  • Patent number: 4425150
    Abstract: A novel agriculturally useful composition that includes a seed treated with a selected infectivity-cured Hr plasmid-bearing microorganism. Also provided are methods of enhancing root elongation, shoot elongation or root development of selected seeds. These methods include treating a selected seed with the infectivity-cured Hr plasmid-bearing microorganism. In addition, there is provided a method of inducing germination of Kentucky bluegrass seed that involves treating Kentucky bluegrass seed with a selected infectivity-cured Hr plasmid-bearing microorganism. Furthermore, there is provided a method of promoting plant growth at a lower soil temperature than is common at the time of planting a seed of the plant. Additionally, there is disclosed an inoculant for increasing nodulation, root mass and shoot mass in a leguminous plant. The inoculant contains a Rhizobium microorganism and a selected infectivity-cured Hr plasmid-bearing microorganism.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: January 10, 1984
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Andrea H. Gavlak, Jesse M. Jaynes