Abstract: The present invention provides polypeptide sequences which, when fused to a heterologous polypeptide, promote secretion of the resulting chimeric protein, and uses thereof.

Abstract: A fluid transfer device for accessing fluid from vials and ampoules includes a cannula assembly including a cannula having a lumen therethrough connected to a hub having an open proximal end. A filling straw includes a housing at its proximal end, a needle portion at its distal end and a shaft portion therebetween. The housing includes a cavity in its proximal end in fluid communication with a passageway running through the filling straw. A cutting edge is provided at the distal end of the needle portion for piercing a vial stopper. The cannula assembly is removably engaged with the housing so that the open proximal end of the hub is in fluid communication with the passageway of the filling straw. An elongate shield having an open proximal end and a recess therein is removably connected to the straw so that the shaft portion and the needle portion of the straw are contained within the recess.

Abstract: A fluid transfer device for accessing fluid from vials and ampoules includes a cannula assembly including a cannula having a lumen therethrough connected to a hub having an open proximal end. A filling straw includes a housing at its proximal end, a needle portion at its distal end and a shaft portion therebetween. The housing includes a cavity in its proximal end in fluid communication with a passageway running through the filling straw. A cutting edge is provided at the distal end of the needle portion for piercing a vial stopper. The cannula assembly is removably engaged with the housing so that the open proximal end of the hub is in fluid communication with the passageway of the filling straw. An elongate shield having an open proximal end and a recess therein is removably connected to the straw so that the shaft portion and the needle portion of the straw are contained within the recess.

Abstract: A fluid transfer device for accessing fluid from vials and ampoules includes a cannula assembly including a cannula having a lumen therethrough connected to a hub having an open proximal end. A filling straw includes a proximal end, a distal end, and a passageway therethrough. The straw further includes a needle portion at the distal end and a shaft portion between the needle portion and the proximal end. A cutting edge is provided at the distal end of the needle portion for piercing a vial stopper. The cannula assembly is removably engaged with the filling straw so that the open proximal end of the hub is in fluid communication with the passageway of the filling straw. An elongate shield having an open proximal end, an open distal end and a side wall therebetween defining a recess in the shield. The shield is removably connected to the straw so that the shaft portion and the needle portion of the straw are contained within the recess. A seal plug having a proximal end and a distal end is provided.