Patents by Inventor Gary F. Blackburn
Gary F. Blackburn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170079750Abstract: The present invention relates to an improved orthodontic bracket mountable on a tooth surface for use in orthodontic mechanics to facilitate movement of teeth along an arch defined by the shape of an arch wire. This orthodontic bracket appliance of the invention provides reduced resistance to sliding during orthodontic tooth movement by incorporating rotating members within the arch wire channel or tube to reduce friction.Type: ApplicationFiled: April 13, 2016Publication date: March 23, 2017Inventors: Gary F Blackburn, James Newell Blackburn
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Patent number: 7462322Abstract: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.Type: GrantFiled: August 6, 2004Date of Patent: December 9, 2008Assignee: Bioveris CorporationInventors: John K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
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Patent number: 6881589Abstract: The invention provides compositions and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence. The compositions and kits comprise an electrochemiluminescent label, collectable particles, binding reagents, and an electrolyte.Type: GrantFiled: June 5, 1995Date of Patent: April 19, 2005Assignee: BioVeris CorporationInventors: John K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
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Patent number: 6846654Abstract: A system for detecting physical or chemical changes in an environment is disclosed. The system comprises means for conducting a chemical reaction; an active biological molecule whose physiological function is noncatalytic which is capable of catalyzing a chemical reaction wherein at least one reactant is converted to one product; and means for sensing and processing information relating to changes in said environment. A method for detecting physical or chemical changes in an environment is also disclosed.Type: GrantFiled: July 9, 1993Date of Patent: January 25, 2005Assignee: IGEN International, Inc.Inventors: Gary F. Blackburn, Charles Durfor, Michael J. Powell, Richard J. Massey
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Publication number: 20040053290Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: April 11, 2003Publication date: March 18, 2004Inventors: Robert Henry Terbrueggen, Gary F. Blackburn, Marc Kenneth Chason, Xunhu Dai, Manes Eliacin, Piotr Grodzinski, Bruce Duncan Irvine, Jon Faiz Kayyem, Keryn Ke Lian, Robin Hui Liu, Shawn Michael O'Rourke, Edward Lewis Sheldon, Frederic Zenhausern
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Publication number: 20030008339Abstract: What is described are methods and apparatus for performing a binding assay for an analyte of interest present in a sample. The methods include the steps of: forming a composition containing the sample, an assay-performance-substance which contains a component linked to a label compound capable of chemiluminescing when triggered, and a plurality of particles capable of specifically binding with the analyte and/or the assay-performance-substance; incubating the composition to form a complex which includes a particle and the labeled component; collecting the complex in a collection zone; introducing into the collection zone a trigger capable of triggering the label such that the label luminesces; and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.Type: ApplicationFiled: September 5, 2002Publication date: January 9, 2003Applicant: Igen, Inc.Inventors: Richard J. Massey, Gary F. Blackburn, Elizabeth W. Wilkins, Haresh P. Shah
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Patent number: 6448091Abstract: Methods and apparatus for performing a binding assay for an analyte of interest present in a sample are described. The methods include the steps of: forming a composition containing the sample, an assay-performance-substance which contains a component linked to a label compound capable of chemiluminescing when triggered, and a plurality of particles capable of specifically binding with the analyte and/or the assay-performance-substance; incubating the composition to form a complex which includes a particle and the labeled component; collecting the complex in a collection zone; introducing into the collection zone a trigger capable of triggering the label such that the label luminesces; and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.Type: GrantFiled: November 7, 1994Date of Patent: September 10, 2002Assignee: IGEN International, Inc.Inventors: Richard J. Massey, Gary F. Blackburn, Elizabeth W. Wilkins, Haresh P. Shah
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Patent number: 6325973Abstract: An apparatus for performing a binding assay for an analyte of interest in a sample based upon measurement of clectrochemiluminescence at an electrode surface comprising: (a) a cell defining a sample; (b) an electrode adjacent a portion of the sample containing volume; (c) a voltage control device for impressing electrochemical energy upon the electrode sufficient to generate luminescence; (d) means for magnetically collecting particles along the electrode surface; and (e) a light detection device for measuring the luminescence.Type: GrantFiled: February 19, 1999Date of Patent: December 4, 2001Assignee: IGEN International, Inc.Inventors: John K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
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Patent number: 6177270Abstract: Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression.Type: GrantFiled: January 21, 1999Date of Patent: January 23, 2001Assignee: IGEN International, Inc.Inventors: Mark T. Martin, Rodger G. Smith, Michael J. Darsley, David M. Simpson, Gary F. Blackburn
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Patent number: 6132955Abstract: An electrode can be derivitized by contacting it with a derivitizing solution to make it more sensitive to a desired analyte signal as opposed to interfering signals in an assay. Particularly, in an electrochemiluminescence (ECL) immunoassay the working electrode can be derivitized to be more sensitive to desired analyte signals, as opposed to interfering non-bound conjugate or serum matrix signals.Type: GrantFiled: September 3, 1997Date of Patent: October 17, 2000Assignee: IGEN International, Inc.Inventors: David Talley, Jonathan K. Leland, Gary F. Blackburn
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Patent number: 6121007Abstract: Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression.Type: GrantFiled: November 13, 1996Date of Patent: September 19, 2000Assignee: IGEN International Inc.Inventors: Mark T. Martin, Rodger G. Smith, Michael J. Darsley, David M. Simpson, Gary F. Blackburn
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Patent number: 6078782Abstract: The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemiluminescence is related to the amount of analyte in the sample.Type: GrantFiled: June 7, 1995Date of Patent: June 20, 2000Assignee: IGEN International Inc.Inventors: John K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
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Patent number: 5962218Abstract: The invention relates to methods, apparatus, reagents, and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. In the method, reagents and kits particles can be employed; for instance, for settling upon the electrode surface by gravity, centrifugation or magnetic attraction. The apparatus can include a magnet for generating a magnetic field in a region proximate the electrode.Type: GrantFiled: November 24, 1993Date of Patent: October 5, 1999Assignee: IGEN International Inc.Inventors: Jonathan K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Gary F. Blackburn, Richard J. Massey
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Patent number: 5935779Abstract: The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemilurninescence is related to the amount of analyte in the sample.Type: GrantFiled: November 30, 1994Date of Patent: August 10, 1999Assignee: IGEN International Inc.Inventors: Richard J. Massey, Jonathan K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn
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Patent number: 5891648Abstract: Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression.Type: GrantFiled: November 13, 1996Date of Patent: April 6, 1999Assignee: Igen, Inc.Inventors: Mark T. Martin, Rodger G. Smith, Michael J. Darsley, David M. Simpson, Gary F. Blackburn
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Patent number: 5798083Abstract: What is described are methods and apparatus for performing a binding assay for an analyte of interest present in a sample. The methods include the steps of: forming a composition containing the sample, an assay-performance-substance which contains a component linked to a label compound capable of chemiluminescing when triggered, and a plurality of particles capable of specifically binding with the analyte and/or the assay-performance-substance; incubating the composition to form a complex which includes a particle and the labeled component; collecting the complex in a collection zone; introducing into the collection zone a trigger capable of triggering the label such that the label luminesces; and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.Type: GrantFiled: June 6, 1995Date of Patent: August 25, 1998Assignee: IGEN International, Inc.Inventors: Richard J. Massey, Gary F. Blackburn, Elizabeth W. Wilkins, Haresh P. Shah
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Patent number: 5779976Abstract: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.Type: GrantFiled: June 5, 1995Date of Patent: July 14, 1998Assignee: IGEN International, Inc.Inventors: Jonathan K. Leland, Haresh P. Shah, John Henry Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
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Patent number: 5770459Abstract: What is described are methods and apparatus for performing a binding assay for an analyte of interest present in a sample. The methods include the steps of: forming a composition containing said sample, an assay-performance-substance which contains a component linked to a label compound capable of chemiluminescing when triggered, and a plurality of coated magnetic particles capable of specifically binding with the analyte and/or said assay-performance-substance; incubating said composition to form a complex which includes a particle and said labeled component; magnetically collecting said complex at the surface of an electrode; inducing said label to luminesce by contacting it with a trigger, said trigger being formed in-situ by conversion of a precursor molecule upon introduction of electrochemical energy; and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.Type: GrantFiled: December 1, 1994Date of Patent: June 23, 1998Assignee: IGEN International, Inc.Inventors: Richard J. Massey, Gary F. Blackburn, Elizabeth W. Wilkins, Jonathan K. Leland
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Patent number: 5746974Abstract: What is described are methods and apparatus for performing a binding assay for an analyte of interest present in a sample. The methods include the steps of: forming a composition containing said sample, an assay-performance-substance which contains a component linked to a label compound capable of chemiluminescing when triggered, and a plurality of coated magnetic particles capable of specifically binding with the analyte and/or said assay-performance-substance; incubating said composition to form a complex which includes a particle and said labeled component; magnetically collecting said complex at the surface of an electrode; inducing said label to luminesce by contacting it with a trigger, said trigger being formed in-situ by conversion of a precursor molecule upon introduction of electrochemical energy; and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.Type: GrantFiled: June 6, 1995Date of Patent: May 5, 1998Assignee: IGEN International, Inc.Inventors: Richard J. Massey, Gary F. Blackburn, Elizabeth W. Wilkins, Jonathan K. Leland
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Patent number: 5705402Abstract: Disclosed and claimed are methods and apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode. The method uses magnetically responsive particles. The method and apparatus call for a plurality of electromagnets or permanent magnets in north-south orientation for imposing a magnetic field so as to collect the particles.Type: GrantFiled: June 8, 1994Date of Patent: January 6, 1998Assignees: Igen International, Inc., Eisai Co. Ltd.Inventors: Jonathan K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey