Patents by Inventor Gary Harold Birnberg

Gary Harold Birnberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted isoquinoline-1,3(2,4)-diones, 1-thioxo,1,4-dihydro-2-isoquinoline-3-ones and 1,4-dihyro-3 (2)-isoquinolones and methods of use thereof
    Patent number: 7713994
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 11, 2010
    Assignee: Wyeth LLC
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Middleton Brawner Floyd, Joshua Kaplan, Kristina M. Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Adufa Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Christian Mayer, Annette L. Banker, Marvin Reich
  • 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
    Publication number: 20100068204
    Abstract: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
    Type: Application
    Filed: September 14, 2009
    Publication date: March 18, 2010
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Gary Harold Birnberg, Gloria Jean MacEwan, Mercy Adufa Otteng, Pawel Wojciech Nowak, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Arie Zask, Ker Yu
  • 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090311217
    Abstract: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 17, 2009
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Nan Zhang, Semiramis Ayral-Kaloustian, James Thomas Anderson, Thai Hiep Nguyen, Sabrina Lombardi, David Malwitz, Natasja Brooijmans, Derek Cecil Cole, Adam Matthew Gilbert, Pawel Wojciech Nowak, Kaapjoo Park, Sasmita Das, Hwei-Ru Tsou, Aranapakam Mudumbai Venkatesan, Mercy Adufa Otteng, Gary Harold Birnberg, Gloria Jean MacEwan
  • 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090298820
    Abstract: The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 3, 2009
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Gary Harold Birnberg, Gloria Jean MacEwan, Semiramis Ayral-Kaloustian, Matthew Gregory Bursavich, Sabrina Lombardi, Nan Zhang, Adam Matthew Gilbert, George Theordore Grosu, Natasja Brooijmans, Thai Hiep Nguyen
  • Compounds for treating tumors
    Patent number: 7626023
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: December 1, 2009
    Assignee: Wyeth
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • COMPOUNDS FOR TREATING TUMORS
    Publication number: 20080221181
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: April 17, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES
    Publication number: 20080171874
    Abstract: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
    Type: Application
    Filed: March 24, 2008
    Publication date: July 17, 2008
    Applicant: Wyeth
    Inventors: Dan Maarten Berger, Gary Harold Birnberg, Yanyong Wang
  • Compounds for treating tumors
    Patent number: 7390910
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: June 24, 2008
    Assignee: Wyeth
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
    Patent number: 7365197
    Abstract: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Gary Harold Birnberg, Yanong Wang
  • 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase
    Patent number: 6784184
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones of Formula (I), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras-oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: August 31, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Joseph William Epstein, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Edward James Salaski, Gloria Jean Macewan, Katherine Cheung
  • 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase
    Publication number: 20030149063
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-,5- (arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones of Formula (I), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Application
    Filed: August 23, 2002
    Publication date: August 7, 2003
    Applicant: American Cyanamid Company
    Inventors: Joseph William Epstein, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Edward James Salaski, Gloria Jean Macewan, Katherine Cheung
  • Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines
    Publication number: 20020091273
    Abstract: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
    Type: Application
    Filed: January 11, 2002
    Publication date: July 11, 2002
    Applicant: American Home Products Corporation
    Inventors: Dan Maarten Berger, Gary Harold Birnberg, Yanong Daniel Wang
  • Restricted 9-cis retinoids
    Patent number: 5968908
    Abstract: The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing the novel 9-cis-retinoic acid analogs.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: October 19, 1999
    Assignee: American Cyanamid Company
    Inventors: Joseph William Epstein, Feng Ling Qing, Gary Harold Birnberg, Adam Matthew Gilbert