Patents by Inventor Gary J. Cleek

Gary J. Cleek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6093736
    Abstract: The present invention provides compounds of formula I ##STR1## or a pharmaceutical acceptable salt thereof wherein Q, X, Y and R.sub.1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: July 25, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Robert Barbachyn, Richard Charles Thomas, Gary J. Cleek
  • Patent number: 6069141
    Abstract: The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R.sub.1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH.sub.3 ; W is O, or S;Q is a 4-, 5-, 6-, 7-, or 9-membered heterocyclic moiety containing one or more nitrogen, sulfur and/or oxygen. The compounds of the invention are useful as antimicrobial agents for preventing and treating infectious diseases.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: May 30, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Robert Barbachyn, Joel Morris, Donn G. Wishka, Gary J. Cleek, Richard Charles Thomas
  • Patent number: 6043248
    Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R.sub.4 is selected from the group consisitng of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: March 28, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard A. Nugent, Stephen T. Schlachter, Michael J. Murphy, Joel Morris, Richard C. Thomas, Donn G. Wishka, Gary J. Cleek, David R. Graber
  • Patent number: 5990136
    Abstract: The present invention provides compounds of formula 1 ##STR1## or pharmaceutical acceptable salts thereof wherein A and R.sub.1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: November 23, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Robert Barbachyn, Richard Charles Thomas, Gary J. Cleek
  • Patent number: 5981537
    Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R.sup.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: November 9, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard A. Nugent, Stephen T. Schlachter, Michael J. Murphy, Joel Morris, Richard C. Thomas, Donn G. Wishka, Fritz Reusser, Gary J. Cleek, Irene W. Althaus
  • Patent number: 5922707
    Abstract: This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR.sub.1, CR.sub.2 R.sub.3, O, S, SO, or SO.sub.2 ; and Z is NR.sub.4, S, SO, SO.sub.2 or O. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: July 13, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard C. Thomas, Gary J. Cleek, Douglas K. Hutchinson, Hiroyoshi Yamada